Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567124711> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1567124711 abstract "Homogenate of rate testicular tissue (10 000 × g for 20 min) was incubated with labeled lanosterol that was prepared biosynthetically from [2-14C]mevalonate. The oxidative demethylation of lanosterol to C27 sterols was observed by the rate of release of labeled CO2. No absolute requirement for added cofactors was demonstrated. The maximal rate of demethylation by testicular tissue was 4 mμmoles/h per 100 mg protein. The supernatant fraction from high-speed centrifugation of testicular tissue or liver supported the same rate of demethylation by liver microsomes. This rate was 6 times greater than the corresponding rate with testicular microsomes. In the presence of mitochondria, labeled CO2 was liberated from lanosterol by both the demethylation reactions and by the oxidation of the side]hain fragment that is formed during the conversion of C27 sterols to C21 steroids. The rate of conversion of lanosterol to C27 sterols and C21 steroids was determined by difference. Inhibition of demethylation decreased the formation of steroids. The time-course of conversion of labeled lanosterol and [4-14C]cholesterol to testosterone and the effect of inhibition suggest that cholesterol or other C27 sterols are biosynthetic intermediates between lanosterol and testosterone." @default.
- W1567124711 created "2016-06-24" @default.
- W1567124711 creator A5037763647 @default.
- W1567124711 creator A5080906635 @default.
- W1567124711 date "1964-12-01" @default.
- W1567124711 modified "2023-09-26" @default.
- W1567124711 title "Testicular sterols" @default.
- W1567124711 cites W1498504266 @default.
- W1567124711 cites W1579637783 @default.
- W1567124711 cites W163292208 @default.
- W1567124711 cites W1775749144 @default.
- W1567124711 cites W1846788709 @default.
- W1567124711 cites W1936871332 @default.
- W1567124711 cites W1998417329 @default.
- W1567124711 cites W2016735077 @default.
- W1567124711 cites W202331677 @default.
- W1567124711 cites W2052387564 @default.
- W1567124711 cites W2061121667 @default.
- W1567124711 cites W22111516 @default.
- W1567124711 cites W2441970817 @default.
- W1567124711 cites W4236945656 @default.
- W1567124711 cites W478764 @default.
- W1567124711 cites W70639467 @default.
- W1567124711 cites W988114986 @default.
- W1567124711 doi "https://doi.org/10.1016/0926-6542(64)90032-0" @default.
- W1567124711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14266256" @default.
- W1567124711 hasPublicationYear "1964" @default.
- W1567124711 type Work @default.
- W1567124711 sameAs 1567124711 @default.
- W1567124711 citedByCount "5" @default.
- W1567124711 crossrefType "journal-article" @default.
- W1567124711 hasAuthorship W1567124711A5037763647 @default.
- W1567124711 hasAuthorship W1567124711A5080906635 @default.
- W1567124711 hasConcept C104317684 @default.
- W1567124711 hasConcept C126322002 @default.
- W1567124711 hasConcept C134018914 @default.
- W1567124711 hasConcept C150194340 @default.
- W1567124711 hasConcept C181199279 @default.
- W1567124711 hasConcept C185592680 @default.
- W1567124711 hasConcept C190727270 @default.
- W1567124711 hasConcept C202199734 @default.
- W1567124711 hasConcept C2778163477 @default.
- W1567124711 hasConcept C2778718757 @default.
- W1567124711 hasConcept C2779279991 @default.
- W1567124711 hasConcept C2779969316 @default.
- W1567124711 hasConcept C2780902042 @default.
- W1567124711 hasConcept C55493867 @default.
- W1567124711 hasConcept C62231903 @default.
- W1567124711 hasConcept C71315377 @default.
- W1567124711 hasConcept C71924100 @default.
- W1567124711 hasConcept C86803240 @default.
- W1567124711 hasConcept C87644729 @default.
- W1567124711 hasConceptScore W1567124711C104317684 @default.
- W1567124711 hasConceptScore W1567124711C126322002 @default.
- W1567124711 hasConceptScore W1567124711C134018914 @default.
- W1567124711 hasConceptScore W1567124711C150194340 @default.
- W1567124711 hasConceptScore W1567124711C181199279 @default.
- W1567124711 hasConceptScore W1567124711C185592680 @default.
- W1567124711 hasConceptScore W1567124711C190727270 @default.
- W1567124711 hasConceptScore W1567124711C202199734 @default.
- W1567124711 hasConceptScore W1567124711C2778163477 @default.
- W1567124711 hasConceptScore W1567124711C2778718757 @default.
- W1567124711 hasConceptScore W1567124711C2779279991 @default.
- W1567124711 hasConceptScore W1567124711C2779969316 @default.
- W1567124711 hasConceptScore W1567124711C2780902042 @default.
- W1567124711 hasConceptScore W1567124711C55493867 @default.
- W1567124711 hasConceptScore W1567124711C62231903 @default.
- W1567124711 hasConceptScore W1567124711C71315377 @default.
- W1567124711 hasConceptScore W1567124711C71924100 @default.
- W1567124711 hasConceptScore W1567124711C86803240 @default.
- W1567124711 hasConceptScore W1567124711C87644729 @default.
- W1567124711 hasLocation W15671247111 @default.
- W1567124711 hasLocation W15671247112 @default.
- W1567124711 hasOpenAccess W1567124711 @default.
- W1567124711 hasPrimaryLocation W15671247111 @default.
- W1567124711 hasRelatedWork W1498504266 @default.
- W1567124711 hasRelatedWork W1775749144 @default.
- W1567124711 hasRelatedWork W1970488272 @default.
- W1567124711 hasRelatedWork W1972646729 @default.
- W1567124711 hasRelatedWork W1974716136 @default.
- W1567124711 hasRelatedWork W2003531395 @default.
- W1567124711 hasRelatedWork W2010444847 @default.
- W1567124711 hasRelatedWork W2028090442 @default.
- W1567124711 hasRelatedWork W2044800591 @default.
- W1567124711 hasRelatedWork W2046478212 @default.
- W1567124711 hasRelatedWork W2056726781 @default.
- W1567124711 hasRelatedWork W2065991417 @default.
- W1567124711 hasRelatedWork W2074731939 @default.
- W1567124711 hasRelatedWork W2083077266 @default.
- W1567124711 hasRelatedWork W2085205869 @default.
- W1567124711 hasRelatedWork W2094301345 @default.
- W1567124711 hasRelatedWork W2431314427 @default.
- W1567124711 hasRelatedWork W2441970817 @default.
- W1567124711 hasRelatedWork W478764 @default.
- W1567124711 hasRelatedWork W988114986 @default.
- W1567124711 isParatext "false" @default.
- W1567124711 isRetracted "false" @default.
- W1567124711 magId "1567124711" @default.
- W1567124711 workType "article" @default.