FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567143501> ?p ?o ?g. }

• W1567143501 endingPage "378" @default.
• W1567143501 startingPage "365" @default.
• W1567143501 abstract "To determine whether antigen-presenting ability might be involved in the superior immunogenicity of chemically xenogenized tumors over that of parental cells, we tested a murine lymphoma line xenogenized by a triazene derivative for expression of Ia antigens, ability to present soluble antigen in vitro, and production of factor(s) active in a mouse thymocyte assay. Results showed that Ia antigens, absent on nonimmunogenic parental L5178 Y cells, were expressed on a xenogenized, highly immunogenic tumor variant (clone D), as detected by immunofluorescence. While the ability of parental cells to stimulate lymphocyte proliferation in vitro was lost on removal of Ia+ cells from the responder population, considerable augmentation of reactivity was observed upon depletion of Ia+ cells from the population of splenocytes responding to the xenogenized cells. Under these conditions, stimulation was blocked by anti-Ia antibodies, or an anti-L3T4 reagent or antibodies to the novel antigenic determinants induced by xenogenization. In addition, no stimulating activity was observed following exposure of clone D cells to glutaraldehyde or lysosomotropic agents such as chloroquine and ammonia. When the ability of clone D cells to present ovalbumin in vitro was assayed, it was found that the xenogenized cells could present the soluble antigen to specifically primed lymphocytes. Moreover, clone D cells could substitute for splenic adherent cells in the proliferative reaction of splenocytes to concanavalin A. Finally, when the supernate from clone D-cell cultures pulsed with phorbol myristic acetate was tested in a mouse thymocyte assay, considerable IL-1-like activity was disclosed." @default.
• W1567143501 created "2016-06-24" @default.
• W1567143501 creator A5003492189 @default.
• W1567143501 creator A5011703773 @default.
• W1567143501 creator A5020326875 @default.
• W1567143501 creator A5079557352 @default.
• W1567143501 creator A5087834518 @default.
• W1567143501 creator A5089266429 @default.
• W1567143501 date "1988-02-01" @default.
• W1567143501 modified "2023-10-05" @default.
• W1567143501 title "Cell-mediated immunity to chemically xenogenized tumors" @default.
• W1567143501 cites W1504492615 @default.
• W1567143501 cites W1506157243 @default.
• W1567143501 cites W1533530009 @default.
• W1567143501 cites W1547913407 @default.
• W1567143501 cites W1576863849 @default.
• W1567143501 cites W1680198589 @default.
• W1567143501 cites W1801100585 @default.
• W1567143501 cites W1963553447 @default.
• W1567143501 cites W1978108907 @default.
• W1567143501 cites W1985300876 @default.
• W1567143501 cites W1998763389 @default.
• W1567143501 cites W2002328752 @default.
• W1567143501 cites W2015589291 @default.
• W1567143501 cites W2035470798 @default.
• W1567143501 cites W2044309960 @default.
• W1567143501 cites W2045924479 @default.
• W1567143501 cites W2070969528 @default.
• W1567143501 cites W2073977304 @default.
• W1567143501 cites W2078058864 @default.
• W1567143501 cites W2092505370 @default.
• W1567143501 cites W2104003910 @default.
• W1567143501 cites W2125841464 @default.
• W1567143501 cites W2132785861 @default.
• W1567143501 cites W2133866634 @default.
• W1567143501 cites W2136409289 @default.
• W1567143501 cites W2140985128 @default.
• W1567143501 cites W2162232725 @default.
• W1567143501 cites W2167538113 @default.
• W1567143501 cites W2168894946 @default.
• W1567143501 cites W2254490188 @default.
• W1567143501 cites W2412941035 @default.
• W1567143501 cites W4313354158 @default.
• W1567143501 cites W956504724 @default.
• W1567143501 doi "https://doi.org/10.1016/0008-8749(88)90100-1" @default.
• W1567143501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3123072" @default.
• W1567143501 hasPublicationYear "1988" @default.
• W1567143501 type Work @default.
• W1567143501 sameAs 1567143501 @default.
• W1567143501 citedByCount "15" @default.
• W1567143501 crossrefType "journal-article" @default.
• W1567143501 hasAuthorship W1567143501A5003492189 @default.
• W1567143501 hasAuthorship W1567143501A5011703773 @default.
• W1567143501 hasAuthorship W1567143501A5020326875 @default.
• W1567143501 hasAuthorship W1567143501A5079557352 @default.
• W1567143501 hasAuthorship W1567143501A5087834518 @default.
• W1567143501 hasAuthorship W1567143501A5089266429 @default.
• W1567143501 hasConcept C144024400 @default.
• W1567143501 hasConcept C147483822 @default.
• W1567143501 hasConcept C149923435 @default.
• W1567143501 hasConcept C153911025 @default.
• W1567143501 hasConcept C167672396 @default.
• W1567143501 hasConcept C189976730 @default.
• W1567143501 hasConcept C203014093 @default.
• W1567143501 hasConcept C2778954852 @default.
• W1567143501 hasConcept C2908647359 @default.
• W1567143501 hasConcept C552990157 @default.
• W1567143501 hasConcept C55493867 @default.
• W1567143501 hasConcept C81089528 @default.
• W1567143501 hasConcept C86803240 @default.
• W1567143501 hasConceptScore W1567143501C144024400 @default.
• W1567143501 hasConceptScore W1567143501C147483822 @default.
• W1567143501 hasConceptScore W1567143501C149923435 @default.
• W1567143501 hasConceptScore W1567143501C153911025 @default.
• W1567143501 hasConceptScore W1567143501C167672396 @default.
• W1567143501 hasConceptScore W1567143501C189976730 @default.
• W1567143501 hasConceptScore W1567143501C203014093 @default.
• W1567143501 hasConceptScore W1567143501C2778954852 @default.
• W1567143501 hasConceptScore W1567143501C2908647359 @default.
• W1567143501 hasConceptScore W1567143501C552990157 @default.
• W1567143501 hasConceptScore W1567143501C55493867 @default.
• W1567143501 hasConceptScore W1567143501C81089528 @default.
• W1567143501 hasConceptScore W1567143501C86803240 @default.
• W1567143501 hasIssue "2" @default.
• W1567143501 hasLocation W15671435011 @default.
• W1567143501 hasLocation W15671435012 @default.
• W1567143501 hasOpenAccess W1567143501 @default.
• W1567143501 hasPrimaryLocation W15671435011 @default.
• W1567143501 hasRelatedWork W1584407678 @default.
• W1567143501 hasRelatedWork W1980252371 @default.
• W1567143501 hasRelatedWork W1989343788 @default.
• W1567143501 hasRelatedWork W2032265229 @default.
• W1567143501 hasRelatedWork W2032998687 @default.
• W1567143501 hasRelatedWork W2038990347 @default.
• W1567143501 hasRelatedWork W2063394100 @default.
• W1567143501 hasRelatedWork W2077863171 @default.
• W1567143501 hasRelatedWork W2409469857 @default.
• W1567143501 hasRelatedWork W2473997354 @default.

• next