Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567143942> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1567143942 endingPage "2753" @default.
- W1567143942 startingPage "2747" @default.
- W1567143942 abstract "Abstract Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease if the central nervous system (CNS). Recently, the type I IFN, IFN-beta-1b was demonstrated to be a useful immunotherapy for MS. During treatment with IFN-beta-1b, toxicity at higher doses has been observed. IFN-tau, discovered for its role in the reproductive cycle, possesses all of the functions normally ascribed to the type I IFNs but lacks the toxicity normally associate with IFN treatment in vitro. We have examined the effects of IFN-tau treatment on experimental allergic encephalomyelitis (EAE), an animal model useful for the study of MS. EAE is a model of Ag-induced autoimmunity that can be modulated by bacterial superantigen to resemble the relapsing-remitting pattern of autoimmune disease observed in MS. IFN-tau was able to prevent development of EAE as effectively as IFN-beta but without associated toxicity such as lymphocyte suppression and weight loss. In addition, IFN-tau was able to prevent superantigen reactivation of EAE akin to the reduction in disease exacerbations observed in IFN-beta-1b treated MS patients. Mechanisms by which IFN-tau may prevent EAE include reduced proliferation in response to the autoantigen myelin basic protein and reduced TNF-alpha production. Thus, IFN-tau may prove to be a promising new IFN therapy for MS in light of its ability to prevent EAE and the lack of toxicity exhibited by this novel IFN." @default.
- W1567143942 created "2016-06-24" @default.
- W1567143942 creator A5014543258 @default.
- W1567143942 creator A5023419211 @default.
- W1567143942 creator A5040070946 @default.
- W1567143942 creator A5045134210 @default.
- W1567143942 creator A5050948016 @default.
- W1567143942 date "1995-09-01" @default.
- W1567143942 modified "2023-10-18" @default.
- W1567143942 title "The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity." @default.
- W1567143942 doi "https://doi.org/10.4049/jimmunol.155.5.2747" @default.
- W1567143942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7544384" @default.
- W1567143942 hasPublicationYear "1995" @default.
- W1567143942 type Work @default.
- W1567143942 sameAs 1567143942 @default.
- W1567143942 citedByCount "54" @default.
- W1567143942 countsByYear W15671439422012 @default.
- W1567143942 countsByYear W15671439422013 @default.
- W1567143942 countsByYear W15671439422014 @default.
- W1567143942 countsByYear W15671439422016 @default.
- W1567143942 countsByYear W15671439422017 @default.
- W1567143942 countsByYear W15671439422018 @default.
- W1567143942 crossrefType "journal-article" @default.
- W1567143942 hasAuthorship W1567143942A5014543258 @default.
- W1567143942 hasAuthorship W1567143942A5023419211 @default.
- W1567143942 hasAuthorship W1567143942A5040070946 @default.
- W1567143942 hasAuthorship W1567143942A5045134210 @default.
- W1567143942 hasAuthorship W1567143942A5050948016 @default.
- W1567143942 hasBestOaLocation W15671439421 @default.
- W1567143942 hasConcept C126322002 @default.
- W1567143942 hasConcept C203014093 @default.
- W1567143942 hasConcept C2776090121 @default.
- W1567143942 hasConcept C2777899865 @default.
- W1567143942 hasConcept C2778486448 @default.
- W1567143942 hasConcept C2778609137 @default.
- W1567143942 hasConcept C2780130043 @default.
- W1567143942 hasConcept C2780640218 @default.
- W1567143942 hasConcept C2780876595 @default.
- W1567143942 hasConcept C29730261 @default.
- W1567143942 hasConcept C36333154 @default.
- W1567143942 hasConcept C529278444 @default.
- W1567143942 hasConcept C71924100 @default.
- W1567143942 hasConcept C8891405 @default.
- W1567143942 hasConceptScore W1567143942C126322002 @default.
- W1567143942 hasConceptScore W1567143942C203014093 @default.
- W1567143942 hasConceptScore W1567143942C2776090121 @default.
- W1567143942 hasConceptScore W1567143942C2777899865 @default.
- W1567143942 hasConceptScore W1567143942C2778486448 @default.
- W1567143942 hasConceptScore W1567143942C2778609137 @default.
- W1567143942 hasConceptScore W1567143942C2780130043 @default.
- W1567143942 hasConceptScore W1567143942C2780640218 @default.
- W1567143942 hasConceptScore W1567143942C2780876595 @default.
- W1567143942 hasConceptScore W1567143942C29730261 @default.
- W1567143942 hasConceptScore W1567143942C36333154 @default.
- W1567143942 hasConceptScore W1567143942C529278444 @default.
- W1567143942 hasConceptScore W1567143942C71924100 @default.
- W1567143942 hasConceptScore W1567143942C8891405 @default.
- W1567143942 hasIssue "5" @default.
- W1567143942 hasLocation W15671439421 @default.
- W1567143942 hasOpenAccess W1567143942 @default.
- W1567143942 hasPrimaryLocation W15671439421 @default.
- W1567143942 hasRelatedWork W165035876 @default.
- W1567143942 hasRelatedWork W2015271395 @default.
- W1567143942 hasRelatedWork W2017885089 @default.
- W1567143942 hasRelatedWork W2045669466 @default.
- W1567143942 hasRelatedWork W2056356293 @default.
- W1567143942 hasRelatedWork W2142129374 @default.
- W1567143942 hasRelatedWork W2415044233 @default.
- W1567143942 hasRelatedWork W2415883113 @default.
- W1567143942 hasRelatedWork W4313388172 @default.
- W1567143942 hasRelatedWork W97721380 @default.
- W1567143942 hasVolume "155" @default.
- W1567143942 isParatext "false" @default.
- W1567143942 isRetracted "false" @default.
- W1567143942 magId "1567143942" @default.
- W1567143942 workType "article" @default.