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• W1567148978 startingPage "1772" @default.
• W1567148978 abstract "Abstract α-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecules and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated DCs produced low levels of IL-12 and TNF-α, a cytokine pattern that could hamper an efficient antitumor immune response. Ex vivo, APCs of patients with HCC and high levels of AFP produced lower levels of TNF-α than that of healthy individuals. In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control." @default.
• W1567148978 created "2016-06-24" @default.
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• W1567148978 date "2004-08-01" @default.
• W1567148978 modified "2023-10-14" @default.
• W1567148978 title "α-Fetoprotein Impairs APC Function and Induces Their Apoptosis" @default.
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• W1567148978 doi "https://doi.org/10.4049/jimmunol.173.3.1772" @default.
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