Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567151243> ?p ?o ?g. }
- W1567151243 endingPage "313" @default.
- W1567151243 startingPage "307" @default.
- W1567151243 abstract "Purpose of review The aims of this article are to discuss the epidemiology, pathophysiology and clinical phenomenology of neurosarcoidosis, as well as current approaches to diagnosis and treatment. This review focuses on central nervous system (CNS) complications of sarcoidosis. Recent findings Neurosarcoidosis is a rare disorder with diverse clinical manifestations and outcomes. It is often difficult to diagnose and even more difficult to treat. New diagnostic approaches include the use of [18F]-fluorodeoxyglucose PET to identify potential biopsy sites. Success has been reported in the treatment of steroid refractory cases with disease-modifying therapies that were originally designed to manage other chronic inflammatory conditions by neutralizing key cytokines or depleting leukocyte subsets. Summary The diagnosis and management of neurosarcoidosis can be challenging. Currently, the disorder is treated with corticosteroids in combination with global immunosuppressant agents and/or immunomodulatory monoclonal antibodies, such as infliximab. The development of novel CNS penetrant drugs that are particularly effective at inhibiting granuloma formation would represent a significant therapeutic advance. Future progress will be informed by a deeper understanding of the pathways underlying the granulomatous inflammation characteristic of sarcoidosis and by an increased appreciation of how sarcoid lesions evolve in the CNS microenvironment." @default.
- W1567151243 created "2016-06-24" @default.
- W1567151243 creator A5039903543 @default.
- W1567151243 date "2013-06-01" @default.
- W1567151243 modified "2023-10-06" @default.
- W1567151243 title "Neurosarcoidosis" @default.
- W1567151243 cites W1531605330 @default.
- W1567151243 cites W1588130494 @default.
- W1567151243 cites W1602165820 @default.
- W1567151243 cites W1843368655 @default.
- W1567151243 cites W186732450 @default.
- W1567151243 cites W1963660987 @default.
- W1567151243 cites W1964642593 @default.
- W1567151243 cites W1967956104 @default.
- W1567151243 cites W1970834664 @default.
- W1567151243 cites W1971933080 @default.
- W1567151243 cites W1972789732 @default.
- W1567151243 cites W1973095869 @default.
- W1567151243 cites W1977065248 @default.
- W1567151243 cites W1977233832 @default.
- W1567151243 cites W1986066758 @default.
- W1567151243 cites W1988683795 @default.
- W1567151243 cites W1989824646 @default.
- W1567151243 cites W1993175409 @default.
- W1567151243 cites W1993830805 @default.
- W1567151243 cites W2001149578 @default.
- W1567151243 cites W2002887643 @default.
- W1567151243 cites W2006578039 @default.
- W1567151243 cites W2009515867 @default.
- W1567151243 cites W2021421980 @default.
- W1567151243 cites W2021502448 @default.
- W1567151243 cites W2022870863 @default.
- W1567151243 cites W2025607940 @default.
- W1567151243 cites W2027210375 @default.
- W1567151243 cites W2028711297 @default.
- W1567151243 cites W2029603175 @default.
- W1567151243 cites W2034861538 @default.
- W1567151243 cites W2037517558 @default.
- W1567151243 cites W2039778296 @default.
- W1567151243 cites W2044606925 @default.
- W1567151243 cites W2046470313 @default.
- W1567151243 cites W2047015768 @default.
- W1567151243 cites W2057915839 @default.
- W1567151243 cites W2058667204 @default.
- W1567151243 cites W2059813521 @default.
- W1567151243 cites W2060200330 @default.
- W1567151243 cites W2062734278 @default.
- W1567151243 cites W2065485361 @default.
- W1567151243 cites W2070836461 @default.
- W1567151243 cites W2073441784 @default.
- W1567151243 cites W2074403536 @default.
- W1567151243 cites W2075927838 @default.
- W1567151243 cites W2077753096 @default.
- W1567151243 cites W2083591601 @default.
- W1567151243 cites W2085172724 @default.
- W1567151243 cites W2086043480 @default.
- W1567151243 cites W2091759123 @default.
- W1567151243 cites W2092618684 @default.
- W1567151243 cites W2094338449 @default.
- W1567151243 cites W2094512301 @default.
- W1567151243 cites W2094846620 @default.
- W1567151243 cites W2096474010 @default.
- W1567151243 cites W2097966351 @default.
- W1567151243 cites W2105032022 @default.
- W1567151243 cites W2106802440 @default.
- W1567151243 cites W2112632706 @default.
- W1567151243 cites W2112942730 @default.
- W1567151243 cites W2120841781 @default.
- W1567151243 cites W2124248800 @default.
- W1567151243 cites W2132567303 @default.
- W1567151243 cites W2143906479 @default.
- W1567151243 cites W2150574009 @default.
- W1567151243 cites W2160372694 @default.
- W1567151243 cites W2162852067 @default.
- W1567151243 cites W2164460090 @default.
- W1567151243 cites W2166278723 @default.
- W1567151243 cites W2168717067 @default.
- W1567151243 cites W2171270498 @default.
- W1567151243 cites W2172111488 @default.
- W1567151243 cites W2337822254 @default.
- W1567151243 cites W3021472745 @default.
- W1567151243 cites W4229881609 @default.
- W1567151243 cites W4243474209 @default.
- W1567151243 cites W4246683166 @default.
- W1567151243 cites W2110822005 @default.
- W1567151243 doi "https://doi.org/10.1097/wco.0b013e3283608459" @default.
- W1567151243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23571775" @default.
- W1567151243 hasPublicationYear "2013" @default.
- W1567151243 type Work @default.
- W1567151243 sameAs 1567151243 @default.
- W1567151243 citedByCount "62" @default.
- W1567151243 countsByYear W15671512432013 @default.
- W1567151243 countsByYear W15671512432014 @default.
- W1567151243 countsByYear W15671512432015 @default.
- W1567151243 countsByYear W15671512432016 @default.
- W1567151243 countsByYear W15671512432017 @default.
- W1567151243 countsByYear W15671512432018 @default.
- W1567151243 countsByYear W15671512432019 @default.