Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567152521> ?p ?o ?g. }
- W1567152521 abstract "Estimates of the worldwide incidence and mortality from 27 cancers in 2008 have been prepared for 182 countries by the International Agency for Research on Cancer (Ferlay et al., 2010). Overall, an estimated 12.7 million new cancer cases and 7.6 million cancer deaths occur in 2008, with 56% of new cancer cases and 63% of the cancer deaths occurring in the less developed regions of the world. The most commonly diagnosed cancers worldwide are lung (1.61 million, 12.7% of the total), breast (1.38 million, 10.9%) and colorectal cancers (1.23 million, 9.7%). Cancer is neither rare anywhere in the world, nor mainly confined to highresource countries. Many cancer subjects die from cancer as a result of organ failure due to “metastasis” (Geiger & Peeper, 2009), thus indicating that medical control of tumor metastasis leads to a marked improvement in cancer prognosis. The acquisition of the metastatic phenotype is not simply the result of oncogene mutations, but instead is achieved through an interstitial stepwise selection process (Mueller & Fusenig, 2004). The dissociation and migration of cancer cells, together with a breakdown of basement membranes between the parenchyme and stroma, are a prerequisite for tumor invasion. The next sequential events involved in cancer metastasis include the following: (i) penetration of cancer cells to adjacent vessels (i.e., intravasation); (ii) suppressed anoikis (i.e., suspension-induced apoptosis) of cancer cells in blood flow; and (iii) an extravascular migration and re-growth of metastatic cells in the secondary organ. For an establishment of anti-metastasis therapy, it is important to elucidate the basic mechanism(s) whereby tumor metastasis is achieved through a molecular event(s). Hepatocyte growth factor (HGF) was discovered and cloned as a potent mitogen of rat hepatocytes in a primary culture system (Nakamura et al., 1984, 1989; Nakamura, 1991). Beyond its name, HGF is now recognized as an essential organotrophic regulator in almost all tissues (Nakamura, 1991; Rubin et al., 1993; Zarnegar & Michalopoulos, 1995; Birchmeier & Gherardi, 1998; Nakamura & Mizuno, 2010). Actually, HGF induces mitogenic, motogenic" @default.
- W1567152521 created "2016-06-24" @default.
- W1567152521 creator A5011990657 @default.
- W1567152521 creator A5080102542 @default.
- W1567152521 date "2011-12-22" @default.
- W1567152521 modified "2023-10-17" @default.
- W1567152521 title "Endocrine Delivery System of NK4, an HGF-Antagonist and Anti-Angiogenic Regulator, for Inhibitions of Tumor Growth, Invasion and Metastasis" @default.
- W1567152521 cites W101606460 @default.
- W1567152521 cites W1485529375 @default.
- W1567152521 cites W1491071248 @default.
- W1567152521 cites W1516311050 @default.
- W1567152521 cites W1530081569 @default.
- W1567152521 cites W1551629532 @default.
- W1567152521 cites W1563129071 @default.
- W1567152521 cites W1944451093 @default.
- W1567152521 cites W1959606306 @default.
- W1567152521 cites W1968172404 @default.
- W1567152521 cites W1972514043 @default.
- W1567152521 cites W1972780993 @default.
- W1567152521 cites W1974544143 @default.
- W1567152521 cites W1975777116 @default.
- W1567152521 cites W1977029863 @default.
- W1567152521 cites W1978039127 @default.
- W1567152521 cites W1981989535 @default.
- W1567152521 cites W1983822371 @default.
- W1567152521 cites W1984320536 @default.
- W1567152521 cites W1986159749 @default.
- W1567152521 cites W1989401198 @default.
- W1567152521 cites W1992747704 @default.
- W1567152521 cites W1994422135 @default.
- W1567152521 cites W1996389318 @default.
- W1567152521 cites W1997451650 @default.
- W1567152521 cites W1998971866 @default.
- W1567152521 cites W1999090780 @default.
- W1567152521 cites W1999545292 @default.
- W1567152521 cites W2004891705 @default.
- W1567152521 cites W2005782838 @default.
- W1567152521 cites W2006642493 @default.
- W1567152521 cites W2013052673 @default.
- W1567152521 cites W2014024822 @default.
- W1567152521 cites W2014345826 @default.
- W1567152521 cites W2014563731 @default.
- W1567152521 cites W2017804756 @default.
- W1567152521 cites W2022491936 @default.
- W1567152521 cites W2024300823 @default.
- W1567152521 cites W2029339363 @default.
- W1567152521 cites W2031300004 @default.
- W1567152521 cites W2032173335 @default.
- W1567152521 cites W2033764325 @default.
- W1567152521 cites W2034629713 @default.
- W1567152521 cites W2035174231 @default.
- W1567152521 cites W2038101179 @default.
- W1567152521 cites W2039319852 @default.
- W1567152521 cites W2041862855 @default.
- W1567152521 cites W2044673446 @default.
- W1567152521 cites W2045153659 @default.
- W1567152521 cites W2048367533 @default.
- W1567152521 cites W2050983091 @default.
- W1567152521 cites W205133295 @default.
- W1567152521 cites W2054042846 @default.
- W1567152521 cites W2055787036 @default.
- W1567152521 cites W2059950450 @default.
- W1567152521 cites W2060503395 @default.
- W1567152521 cites W2063016516 @default.
- W1567152521 cites W2063808705 @default.
- W1567152521 cites W2073184223 @default.
- W1567152521 cites W2078502914 @default.
- W1567152521 cites W2079278662 @default.
- W1567152521 cites W2081736906 @default.
- W1567152521 cites W2086167068 @default.
- W1567152521 cites W2087677309 @default.
- W1567152521 cites W2095064622 @default.
- W1567152521 cites W2095922927 @default.
- W1567152521 cites W2096230949 @default.
- W1567152521 cites W2107699503 @default.
- W1567152521 cites W2108337520 @default.
- W1567152521 cites W2112266548 @default.
- W1567152521 cites W2113461502 @default.
- W1567152521 cites W2114235123 @default.
- W1567152521 cites W2117199959 @default.
- W1567152521 cites W2119281341 @default.
- W1567152521 cites W2119351872 @default.
- W1567152521 cites W2122682237 @default.
- W1567152521 cites W2125519805 @default.
- W1567152521 cites W2127287125 @default.
- W1567152521 cites W2127371010 @default.
- W1567152521 cites W2138448256 @default.
- W1567152521 cites W2139457018 @default.
- W1567152521 cites W2144960281 @default.
- W1567152521 cites W2147078969 @default.
- W1567152521 cites W2155167580 @default.
- W1567152521 cites W2155493449 @default.
- W1567152521 cites W2156355330 @default.
- W1567152521 cites W2157959228 @default.
- W1567152521 cites W2163581770 @default.
- W1567152521 cites W2334802216 @default.
- W1567152521 cites W2417995166 @default.
- W1567152521 cites W2421691669 @default.
- W1567152521 cites W2106780193 @default.
- W1567152521 cites W2128696591 @default.