FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567174084> ?p ?o ?g. }

• W1567174084 endingPage "138" @default.
• W1567174084 startingPage "126" @default.
• W1567174084 abstract "Measles virus (MV) remains an important pathogen in children worldwide. The morbidity and mortality of MV is associated with severe immune suppression. Dendritic cells (DCs) were identified as initial target cells in vivo, and DCs were efficiently infected by MV in vitro. MV infection of DCs likely contributes to functional deficiency in these cells; therefore playing a role in MV-induced immunosuppression. DCs appeared to mature phenotypically; however, the ability of infected cells to stimulate T cells was compromised. Phenotypic maturation of infected immature DCs was partially controlled by IFN production; however, infected DCs also maintained markers of an immature phenotype such as the continued uptake of antigen and lack of expression of chemokine receptor CCR7. Furthermore, mature DCs did not appear to maintain phenotypic maturation following infection demonstrated by decreased MHC and co-stimulatory molecule expression. Several mechanisms of MV-induced DC dysfunction have been suggested, each likely contributing to the immunosuppressive effect of MV-infected DCs. Infected DCs responded aberrantly to secondary maturation stimuli such as CD40L or TLR4 stimulation. MV infection resulted in apoptosis in DC/T-cell cocultures, which may contribute to a reduced T-cell response. Additionally, the immunological synapse between infected DCs and T cells was compromised resulting in reduced T-cell interaction times and activation signaling. The mechanisms of MV contribution to DC dysfunction appear multifaceted and central to MV-induced immunosuppression. Published 2012. This article is a U.S. Government work and is in the public domain in the USA." @default.
• W1567174084 created "2016-06-24" @default.
• W1567174084 creator A5000572996 @default.
• W1567174084 creator A5040055432 @default.
• W1567174084 creator A5080931087 @default.
• W1567174084 date "2012-12-20" @default.
• W1567174084 modified "2023-09-25" @default.
• W1567174084 title "Contribution of dendritic cells to measles virus induced immunosuppression" @default.
• W1567174084 cites W1526363252 @default.
• W1567174084 cites W1561083995 @default.
• W1567174084 cites W1561788579 @default.
• W1567174084 cites W1605916189 @default.
• W1567174084 cites W1967224261 @default.
• W1567174084 cites W1968201076 @default.
• W1567174084 cites W1969361978 @default.
• W1567174084 cites W1970663308 @default.
• W1567174084 cites W1971084107 @default.
• W1567174084 cites W1978452294 @default.
• W1567174084 cites W1978499990 @default.
• W1567174084 cites W1979223770 @default.
• W1567174084 cites W1979680810 @default.
• W1567174084 cites W1980571072 @default.
• W1567174084 cites W1989186078 @default.
• W1567174084 cites W1995035148 @default.
• W1567174084 cites W2003543308 @default.
• W1567174084 cites W2004805241 @default.
• W1567174084 cites W2015507362 @default.
• W1567174084 cites W2016040683 @default.
• W1567174084 cites W2017851594 @default.
• W1567174084 cites W2019628123 @default.
• W1567174084 cites W2022942735 @default.
• W1567174084 cites W2024754814 @default.
• W1567174084 cites W2026878368 @default.
• W1567174084 cites W2028897854 @default.
• W1567174084 cites W2030022097 @default.
• W1567174084 cites W2033261471 @default.
• W1567174084 cites W2033877575 @default.
• W1567174084 cites W2036764167 @default.
• W1567174084 cites W2039635444 @default.
• W1567174084 cites W2053449086 @default.
• W1567174084 cites W2055174533 @default.
• W1567174084 cites W2067847775 @default.
• W1567174084 cites W2073364449 @default.
• W1567174084 cites W2079814213 @default.
• W1567174084 cites W2081569298 @default.
• W1567174084 cites W2090544067 @default.
• W1567174084 cites W2096876707 @default.
• W1567174084 cites W2099480075 @default.
• W1567174084 cites W2099735180 @default.
• W1567174084 cites W2105110692 @default.
• W1567174084 cites W2105554284 @default.
• W1567174084 cites W2110340781 @default.
• W1567174084 cites W2113243517 @default.
• W1567174084 cites W2115710481 @default.
• W1567174084 cites W2117053011 @default.
• W1567174084 cites W2122832946 @default.
• W1567174084 cites W2125004844 @default.
• W1567174084 cites W2127836459 @default.
• W1567174084 cites W2128131213 @default.
• W1567174084 cites W2131091045 @default.
• W1567174084 cites W2131761283 @default.
• W1567174084 cites W2133723438 @default.
• W1567174084 cites W2133965699 @default.
• W1567174084 cites W2136792869 @default.
• W1567174084 cites W2139401200 @default.
• W1567174084 cites W2140151153 @default.
• W1567174084 cites W2145816564 @default.
• W1567174084 cites W2147458593 @default.
• W1567174084 cites W2151948198 @default.
• W1567174084 cites W2153846132 @default.
• W1567174084 cites W2154334154 @default.
• W1567174084 cites W2155925158 @default.
• W1567174084 cites W2159185426 @default.
• W1567174084 cites W2162250600 @default.
• W1567174084 cites W2166867894 @default.
• W1567174084 doi "https://doi.org/10.1002/rmv.1735" @default.
• W1567174084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23280948" @default.
• W1567174084 hasPublicationYear "2012" @default.
• W1567174084 type Work @default.
• W1567174084 sameAs 1567174084 @default.
• W1567174084 citedByCount "19" @default.
• W1567174084 countsByYear W15671740842013 @default.
• W1567174084 countsByYear W15671740842014 @default.
• W1567174084 countsByYear W15671740842015 @default.
• W1567174084 countsByYear W15671740842016 @default.
• W1567174084 countsByYear W15671740842017 @default.
• W1567174084 countsByYear W15671740842018 @default.
• W1567174084 countsByYear W15671740842019 @default.
• W1567174084 countsByYear W15671740842020 @default.
• W1567174084 countsByYear W15671740842021 @default.
• W1567174084 countsByYear W15671740842022 @default.
• W1567174084 countsByYear W15671740842023 @default.
• W1567174084 crossrefType "journal-article" @default.
• W1567174084 hasAuthorship W1567174084A5000572996 @default.
• W1567174084 hasAuthorship W1567174084A5040055432 @default.
• W1567174084 hasAuthorship W1567174084A5080931087 @default.
• W1567174084 hasConcept C127801297 @default.
• W1567174084 hasConcept C12823836 @default.

• next