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- W1567177283 abstract "Abstract: Because current skin whitening agents often have insufficient efficacy and side effects, we aim to develop effective and safe therapeutics using RNA interference (RNAi). We established a pigmented human‐reconstructed skin model as a first step in the development of novel siRNA‐based depigmenting agents. Histological characterization revealed that our model had a similar morphology as normal human skin, expressed keratinocyte differentiation as well as basement membrane markers, and showed a high degree of pigmentation. The utility of the model to study RNAi‐induced depigmentation was validated by incorporation of melanocytes transfected with siRNA against tyrosinase, a key enzyme in skin pigmentation. This resulted in a strong reduction in pigmentation and inhibition of melanin transfer proving that siRNA‐mediated gene silencing in melanocytes worked successfully in our model. Therefore, this self‐made 3D skin model will be a useful and easy tool to validate the whitening potential of candidate genes with a presumed function in melanin synthesis or transfer." @default.
- W1567177283 created "2016-06-24" @default.
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- W1567177283 date "2011-06-24" @default.
- W1567177283 modified "2023-10-16" @default.
- W1567177283 title "Development of a 3D pigmented skin model to evaluate RNAi-induced depigmentation" @default.
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- W1567177283 doi "https://doi.org/10.1111/j.1600-0625.2011.01319.x" @default.
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