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• W1567179035 abstract "Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They areimplicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheralorgans such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects againstischemia–reperfusion injury in many organs. The goal of this study was to determine the effect of orexin-A on thehepatic dysfunction and histological damage induced by renal ischemia/ reperfusion at an early stage.Methods: Pentobarbital anaesthetized rats were prepared for measuring renal functional variables. Ischemia wasinduced by bilateral renal artery clamping for 30 min followed by a 1 h reperfusion period. In orexin-treated rats, it wasinfused at 500 pmol·kg−1·min−1 (i.v.) from the beginning of pre-ischemic (pretreatment) clearance period. The liver wasexamined using light microscopy.Results: The renal ischemic challenge resulted in hepatic functional and histological damages, which wereassociated with decreased creatinine clearance during the reperfusion period. In orexin-treated rats, the functional and histological damages to the liver were improved along with the decrease in creatinine clearance being smaller than those of the non-treated rats.Conclusion: Orexin-A exhibited an ameliorative effect against renal ischemia/reperfusion-induced lesions in theliver." @default.
• W1567179035 created "2016-06-24" @default.
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• W1567179035 date "2013-10-10" @default.
• W1567179035 modified "2023-09-23" @default.
• W1567179035 title "Orexin-A Improves Hepatic Injury Following Renal Ischemia Reperfusion in Rats" @default.
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