Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567180714> ?p ?o ?g. }
- W1567180714 endingPage "33" @default.
- W1567180714 startingPage "15" @default.
- W1567180714 abstract "In view of the recent studies on the CDCs, a reasonable schematic of the stages leading to membrane insertion of the CDCs can be assembled. As shown in Fig. 3, we propose that the CDC first binds to the membrane as a monomer. These monomers then diffuse laterally on the membrane surface to encounter other monomers or incomplete oligomeric complexes. Presumably, once the requisite oligomer size is reached, the prepore complex is converted into the pore complex and a large membrane channel is formed. During the conversion of the prepore complex to the pore complex, we predict that the TMHs of the subunits in the prepore complex insert into the bilayer in a concerted fashion to form the large transmembrane beta-barrel, although this still remains to be confirmed experimentally. Many intriguing problems concerning the cytolytic mechanism of the CDCs remain unsolved. The nature of the initial interaction of the CDC monomer with the membrane is currently one of the most controversial questions concerning the CDC mechanism. Is cholesterol involved in this interaction, as previously assumed, or do specific receptors exist for these toxins that remain to be discovered? Also, the trigger for membrane insertion and the regions of these toxins that facilitate the [figure: see text] interaction of the monomers during prepore complex formation are unknown. In addition, the temporal sequence of the multiple structural changes that accompany the conversion of the soluble CDC monomer into a membrane-inserted oligomer have yet to be defined or characterized kinetically." @default.
- W1567180714 created "2016-06-24" @default.
- W1567180714 creator A5001106575 @default.
- W1567180714 creator A5002522363 @default.
- W1567180714 creator A5044088516 @default.
- W1567180714 date "2001-01-01" @default.
- W1567180714 modified "2023-10-13" @default.
- W1567180714 title "The Cholesterol-Dependent Cytolysins" @default.
- W1567180714 cites W1486757980 @default.
- W1567180714 cites W1507553352 @default.
- W1567180714 cites W1547944281 @default.
- W1567180714 cites W1564370956 @default.
- W1567180714 cites W1567501609 @default.
- W1567180714 cites W1775765480 @default.
- W1567180714 cites W1806699404 @default.
- W1567180714 cites W1820852202 @default.
- W1567180714 cites W1863042354 @default.
- W1567180714 cites W1906347711 @default.
- W1567180714 cites W1924978529 @default.
- W1567180714 cites W1937064569 @default.
- W1567180714 cites W1953565486 @default.
- W1567180714 cites W1958176909 @default.
- W1567180714 cites W1969051825 @default.
- W1567180714 cites W1970026235 @default.
- W1567180714 cites W1980355157 @default.
- W1567180714 cites W1982619523 @default.
- W1567180714 cites W1999319251 @default.
- W1567180714 cites W1999838506 @default.
- W1567180714 cites W2001276190 @default.
- W1567180714 cites W2002009881 @default.
- W1567180714 cites W2014079110 @default.
- W1567180714 cites W2015148410 @default.
- W1567180714 cites W2016320886 @default.
- W1567180714 cites W2017290264 @default.
- W1567180714 cites W2027492022 @default.
- W1567180714 cites W2030339168 @default.
- W1567180714 cites W2030683115 @default.
- W1567180714 cites W2032099869 @default.
- W1567180714 cites W2033401770 @default.
- W1567180714 cites W2036430109 @default.
- W1567180714 cites W2040800727 @default.
- W1567180714 cites W2044149109 @default.
- W1567180714 cites W2056923102 @default.
- W1567180714 cites W2057417107 @default.
- W1567180714 cites W2061254873 @default.
- W1567180714 cites W2070412894 @default.
- W1567180714 cites W2072199004 @default.
- W1567180714 cites W2075778395 @default.
- W1567180714 cites W2077634814 @default.
- W1567180714 cites W2078665757 @default.
- W1567180714 cites W2080520588 @default.
- W1567180714 cites W2084413039 @default.
- W1567180714 cites W2090821297 @default.
- W1567180714 cites W2095553548 @default.
- W1567180714 cites W2102130081 @default.
- W1567180714 cites W2110573136 @default.
- W1567180714 cites W2114283841 @default.
- W1567180714 cites W2118134410 @default.
- W1567180714 cites W2122000410 @default.
- W1567180714 cites W2129463316 @default.
- W1567180714 cites W2159149219 @default.
- W1567180714 cites W2164801267 @default.
- W1567180714 cites W2165424642 @default.
- W1567180714 cites W2170524958 @default.
- W1567180714 cites W2289361047 @default.
- W1567180714 doi "https://doi.org/10.1007/978-3-642-56508-3_2" @default.
- W1567180714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11417120" @default.
- W1567180714 hasPublicationYear "2001" @default.
- W1567180714 type Work @default.
- W1567180714 sameAs 1567180714 @default.
- W1567180714 citedByCount "69" @default.
- W1567180714 countsByYear W15671807142012 @default.
- W1567180714 countsByYear W15671807142013 @default.
- W1567180714 countsByYear W15671807142014 @default.
- W1567180714 countsByYear W15671807142015 @default.
- W1567180714 countsByYear W15671807142016 @default.
- W1567180714 countsByYear W15671807142017 @default.
- W1567180714 countsByYear W15671807142018 @default.
- W1567180714 countsByYear W15671807142019 @default.
- W1567180714 countsByYear W15671807142020 @default.
- W1567180714 countsByYear W15671807142021 @default.
- W1567180714 countsByYear W15671807142022 @default.
- W1567180714 countsByYear W15671807142023 @default.
- W1567180714 crossrefType "book-chapter" @default.
- W1567180714 hasAuthorship W1567180714A5001106575 @default.
- W1567180714 hasAuthorship W1567180714A5002522363 @default.
- W1567180714 hasAuthorship W1567180714A5044088516 @default.
- W1567180714 hasConcept C12554922 @default.
- W1567180714 hasConcept C159985019 @default.
- W1567180714 hasConcept C166940927 @default.
- W1567180714 hasConcept C170493617 @default.
- W1567180714 hasConcept C172227984 @default.
- W1567180714 hasConcept C178790620 @default.
- W1567180714 hasConcept C185592680 @default.
- W1567180714 hasConcept C188027245 @default.
- W1567180714 hasConcept C192157962 @default.
- W1567180714 hasConcept C192562407 @default.
- W1567180714 hasConcept C24530287 @default.