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• W1567182349 abstract "Vertebrates and microbes live together in a precarious balancing act. Staphylococcus aureus and Streptococcus pyogenes are Gram-positive commensal bacteria that inhabit the human skin, nose, and upper respiratory tract (Wannamaker and Schlievert 1988) and for the most part live an unremarkable, symbiotic existence with humans. Both organisms produce superantigens (SAGs) Table 8.1 that simultaneously bind to the T-cell Receptor (TcR) and the major histocompatibility class II (MHC-II) antigens – two molecules central to host immunity – bringing them together to cause profound T-cell activation (Schlievert, 1993; Marrack and Kappler, 1990; Kotzin et al., 1993; Fleischer, 1994; Acha Orbea and MacDonald, 1995). Any T cell bearing a reactive TcR β-chain becomes a target for a SAG and with only sixty-five TcR β-chain genes resident in the human genome (Rowen et al., 1996), any individual SAG stimulates at least 1–2% of peripheral T cells and often more than this. Superantigen activation produces toxic levels of the pro-inflammatory cytokines Interleukin (IL)-1β, tumour necrosis factor (TNF)-α, and interleukin-2 (IL-2) (see Chapter 10 for more details on cytokines), which can lead to the potentially lethal condition known as toxic shock. SAGs are not limited to S. aureus and S. pyogenes. Versions of SAGs have also been found in a number of other organisms and all cross-link TcR and MHC class II to overstimulate T-lymphocytes" @default.
• W1567182349 created "2016-06-24" @default.
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• W1567182349 date "2003-04-28" @default.
• W1567182349 modified "2023-09-27" @default.
• W1567182349 title "Bacterial superantigens and immune evasion" @default.
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• W1567182349 doi "https://doi.org/10.1017/cbo9780511546266.009" @default.
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