FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567189031> ?p ?o ?g. }

• W1567189031 endingPage "869" @default.
• W1567189031 startingPage "863" @default.
• W1567189031 abstract "A vaccine protecting against all influenza strains is a long-sought goal, particularly for emerging pandemics. As previously shown, vaccines based on the highly conserved extracellular domain of M2 (M2e) may protect against all influenza A strains. Here, we demonstrate that M2e-specific monoclonal antibodies (mAbs) protect mice from a lethal influenza infection. To be protective, antibodies had to be able to bind to Fc receptors and fix complement. Furthermore, mAbs of IgG2c isotype were protective in mice, while antibodies of identical specificity, but of the IgG1 isotype, failed to prevent disease. These findings readily translated into vaccine design. A vaccine targeting M2 in the absence of a toll-like receptor (TLR) 7 ligand primarily induced IgG1, whilst the same vaccine linked to a TLR7 ligand yielded high levels of IgG2c antibodies. Although both vaccines protected mice from a lethal challenge, mice treated with the vaccine containing a TLR7 ligand showed significantly lower morbidity. In accordance with these findings, vaccination of TLR7–/– mice with a vaccine containing a TLR7 ligand did not result in protection from a lethal challenge. Hence, the innate immune system is required to direct isotype switching toward the more protective IgG2a/c antibodies." @default.
• W1567189031 created "2016-06-24" @default.
• W1567189031 creator A5012160425 @default.
• W1567189031 creator A5017850724 @default.
• W1567189031 creator A5019913804 @default.
• W1567189031 creator A5030120350 @default.
• W1567189031 creator A5030616724 @default.
• W1567189031 creator A5054737731 @default.
• W1567189031 creator A5076600519 @default.
• W1567189031 creator A5084014806 @default.
• W1567189031 creator A5091509191 @default.
• W1567189031 date "2012-04-01" @default.
• W1567189031 modified "2023-10-16" @default.
• W1567189031 title "Universal vaccine against influenza virus: Linking TLR signaling to anti-viral protection" @default.
• W1567189031 cites W1493742659 @default.
• W1567189031 cites W1515043996 @default.
• W1567189031 cites W1538591251 @default.
• W1567189031 cites W1546151618 @default.
• W1567189031 cites W1582393017 @default.
• W1567189031 cites W1614256433 @default.
• W1567189031 cites W1655706054 @default.
• W1567189031 cites W1904826643 @default.
• W1567189031 cites W1911055492 @default.
• W1567189031 cites W1967781933 @default.
• W1567189031 cites W1981295756 @default.
• W1567189031 cites W1982701373 @default.
• W1567189031 cites W1986561400 @default.
• W1567189031 cites W1990545448 @default.
• W1567189031 cites W1997341424 @default.
• W1567189031 cites W2002429449 @default.
• W1567189031 cites W2005203390 @default.
• W1567189031 cites W2017003739 @default.
• W1567189031 cites W2024238985 @default.
• W1567189031 cites W2026462640 @default.
• W1567189031 cites W2035068182 @default.
• W1567189031 cites W2037164614 @default.
• W1567189031 cites W2040083468 @default.
• W1567189031 cites W2043837317 @default.
• W1567189031 cites W2048340513 @default.
• W1567189031 cites W2048906642 @default.
• W1567189031 cites W2071404290 @default.
• W1567189031 cites W2071657440 @default.
• W1567189031 cites W2136045853 @default.
• W1567189031 cites W2155517069 @default.
• W1567189031 cites W2163030812 @default.
• W1567189031 cites W2163624071 @default.
• W1567189031 cites W2168257552 @default.
• W1567189031 cites W2170287675 @default.
• W1567189031 cites W4244541582 @default.
• W1567189031 cites W51817657 @default.
• W1567189031 doi "https://doi.org/10.1002/eji.201041225" @default.
• W1567189031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22531913" @default.
• W1567189031 hasPublicationYear "2012" @default.
• W1567189031 type Work @default.
• W1567189031 sameAs 1567189031 @default.
• W1567189031 citedByCount "78" @default.
• W1567189031 countsByYear W15671890312012 @default.
• W1567189031 countsByYear W15671890312013 @default.
• W1567189031 countsByYear W15671890312014 @default.
• W1567189031 countsByYear W15671890312015 @default.
• W1567189031 countsByYear W15671890312016 @default.
• W1567189031 countsByYear W15671890312017 @default.
• W1567189031 countsByYear W15671890312018 @default.
• W1567189031 countsByYear W15671890312019 @default.
• W1567189031 countsByYear W15671890312020 @default.
• W1567189031 countsByYear W15671890312021 @default.
• W1567189031 countsByYear W15671890312022 @default.
• W1567189031 countsByYear W15671890312023 @default.
• W1567189031 crossrefType "journal-article" @default.
• W1567189031 hasAuthorship W1567189031A5012160425 @default.
• W1567189031 hasAuthorship W1567189031A5017850724 @default.
• W1567189031 hasAuthorship W1567189031A5019913804 @default.
• W1567189031 hasAuthorship W1567189031A5030120350 @default.
• W1567189031 hasAuthorship W1567189031A5030616724 @default.
• W1567189031 hasAuthorship W1567189031A5054737731 @default.
• W1567189031 hasAuthorship W1567189031A5076600519 @default.
• W1567189031 hasAuthorship W1567189031A5084014806 @default.
• W1567189031 hasAuthorship W1567189031A5091509191 @default.
• W1567189031 hasBestOaLocation W15671890311 @default.
• W1567189031 hasConcept C136449434 @default.
• W1567189031 hasConcept C159047783 @default.
• W1567189031 hasConcept C159654299 @default.
• W1567189031 hasConcept C203014093 @default.
• W1567189031 hasConcept C22070199 @default.
• W1567189031 hasConcept C2776709828 @default.
• W1567189031 hasConcept C2777991845 @default.
• W1567189031 hasConcept C2779836521 @default.
• W1567189031 hasConcept C2780689484 @default.
• W1567189031 hasConcept C542903549 @default.
• W1567189031 hasConcept C86803240 @default.
• W1567189031 hasConcept C8891405 @default.
• W1567189031 hasConceptScore W1567189031C136449434 @default.
• W1567189031 hasConceptScore W1567189031C159047783 @default.
• W1567189031 hasConceptScore W1567189031C159654299 @default.
• W1567189031 hasConceptScore W1567189031C203014093 @default.
• W1567189031 hasConceptScore W1567189031C22070199 @default.
• W1567189031 hasConceptScore W1567189031C2776709828 @default.
• W1567189031 hasConceptScore W1567189031C2777991845 @default.

• next