FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567192062> ?p ?o ?g. }

• W1567192062 endingPage "604" @default.
• W1567192062 startingPage "587" @default.
• W1567192062 abstract "The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes withcis andtrans cycloalkylamine ligands [cis-PtCl2(C3H5NH2)2 tocis-PtCl2(C8H15NH2)2 (3–8) andtrans-PtCl2(C7H13NH2)2 (9) andtrans-PtCl2(C8H15NH2)2 (10)] are described. The distinction betweencis andtrans isomers was achieved by1H-NMR spectroscopy. The antitumor activity was determined on the cell proliferation of the human MDA-MB-231 breast cancer cell line during long-term drug exposure. The complexes with small cycloalkylamine ligands (3–6) were inferior, those with large cycloalkylamine ligands were comparable (7) or superior (8) to cisplatin. Surprisingly, thecis/trans isomers7/9 and8/10 were equally active. All cycloalkylamine ligands were inactive. IR-spectroscopic studies showed that the size of the cycloalkylamine ring does not lead to significant differences in the Pt-Cl binding strength. Therefore it is assumed that the markedly stronger antitumor activity of the higher homologues,7–10, is not the result of a faster reaction with bionucleophils such as DNA. A possible explanation of the high activity of7–10 is the strong lipophilicity of the complexes. This assumption was confirmed by toxicity tests against confluent cultures." @default.
• W1567192062 created "2016-06-24" @default.
• W1567192062 creator A5003847205 @default.
• W1567192062 creator A5036733779 @default.
• W1567192062 creator A5039692094 @default.
• W1567192062 creator A5055884257 @default.
• W1567192062 creator A5057876555 @default.
• W1567192062 creator A5081466018 @default.
• W1567192062 date "1993-05-01" @default.
• W1567192062 modified "2023-10-15" @default.
• W1567192062 title "Dichlorobis(cycloalkylamine)platinum(II) complexes structure activity relationship on the human MDA-MB-231 breast cancer cell line" @default.
• W1567192062 cites W1506173876 @default.
• W1567192062 cites W1506983576 @default.
• W1567192062 cites W1971602697 @default.
• W1567192062 cites W1979406893 @default.
• W1567192062 cites W1987393218 @default.
• W1567192062 cites W1995810957 @default.
• W1567192062 cites W2009265437 @default.
• W1567192062 cites W2010016280 @default.
• W1567192062 cites W2011477132 @default.
• W1567192062 cites W2012108057 @default.
• W1567192062 cites W2022435979 @default.
• W1567192062 cites W2025293912 @default.
• W1567192062 cites W2034081467 @default.
• W1567192062 cites W2036286319 @default.
• W1567192062 cites W2038214500 @default.
• W1567192062 cites W2041977529 @default.
• W1567192062 cites W2045388444 @default.
• W1567192062 cites W2047864565 @default.
• W1567192062 cites W2068160434 @default.
• W1567192062 cites W2074619839 @default.
• W1567192062 cites W2090498076 @default.
• W1567192062 cites W2094793237 @default.
• W1567192062 cites W2147982205 @default.
• W1567192062 cites W2165516338 @default.
• W1567192062 cites W2228133195 @default.
• W1567192062 cites W3136860880 @default.
• W1567192062 cites W591102621 @default.
• W1567192062 doi "https://doi.org/10.1007/bf00819526" @default.
• W1567192062 hasPublicationYear "1993" @default.
• W1567192062 type Work @default.
• W1567192062 sameAs 1567192062 @default.
• W1567192062 citedByCount "5" @default.
• W1567192062 crossrefType "journal-article" @default.
• W1567192062 hasAuthorship W1567192062A5003847205 @default.
• W1567192062 hasAuthorship W1567192062A5036733779 @default.
• W1567192062 hasAuthorship W1567192062A5039692094 @default.
• W1567192062 hasAuthorship W1567192062A5055884257 @default.
• W1567192062 hasAuthorship W1567192062A5057876555 @default.
• W1567192062 hasAuthorship W1567192062A5081466018 @default.
• W1567192062 hasBestOaLocation W15671920622 @default.
• W1567192062 hasConcept C121608353 @default.
• W1567192062 hasConcept C126322002 @default.
• W1567192062 hasConcept C161790260 @default.
• W1567192062 hasConcept C185592680 @default.
• W1567192062 hasConcept C201399114 @default.
• W1567192062 hasConcept C2776694085 @default.
• W1567192062 hasConcept C2778239845 @default.
• W1567192062 hasConcept C2994372470 @default.
• W1567192062 hasConcept C2994423619 @default.
• W1567192062 hasConcept C518104683 @default.
• W1567192062 hasConcept C54355233 @default.
• W1567192062 hasConcept C55493867 @default.
• W1567192062 hasConcept C71240020 @default.
• W1567192062 hasConcept C71924100 @default.
• W1567192062 hasConcept C81885089 @default.
• W1567192062 hasConcept C86803240 @default.
• W1567192062 hasConcept C96232424 @default.
• W1567192062 hasConceptScore W1567192062C121608353 @default.
• W1567192062 hasConceptScore W1567192062C126322002 @default.
• W1567192062 hasConceptScore W1567192062C161790260 @default.
• W1567192062 hasConceptScore W1567192062C185592680 @default.
• W1567192062 hasConceptScore W1567192062C201399114 @default.
• W1567192062 hasConceptScore W1567192062C2776694085 @default.
• W1567192062 hasConceptScore W1567192062C2778239845 @default.
• W1567192062 hasConceptScore W1567192062C2994372470 @default.
• W1567192062 hasConceptScore W1567192062C2994423619 @default.
• W1567192062 hasConceptScore W1567192062C518104683 @default.
• W1567192062 hasConceptScore W1567192062C54355233 @default.
• W1567192062 hasConceptScore W1567192062C55493867 @default.
• W1567192062 hasConceptScore W1567192062C71240020 @default.
• W1567192062 hasConceptScore W1567192062C71924100 @default.
• W1567192062 hasConceptScore W1567192062C81885089 @default.
• W1567192062 hasConceptScore W1567192062C86803240 @default.
• W1567192062 hasConceptScore W1567192062C96232424 @default.
• W1567192062 hasIssue "5" @default.
• W1567192062 hasLocation W15671920621 @default.
• W1567192062 hasLocation W15671920622 @default.
• W1567192062 hasOpenAccess W1567192062 @default.
• W1567192062 hasPrimaryLocation W15671920621 @default.
• W1567192062 hasRelatedWork W2034934034 @default.
• W1567192062 hasRelatedWork W2038549840 @default.
• W1567192062 hasRelatedWork W2090549309 @default.
• W1567192062 hasRelatedWork W2105144909 @default.
• W1567192062 hasRelatedWork W2151433903 @default.
• W1567192062 hasRelatedWork W2162022473 @default.
• W1567192062 hasRelatedWork W2942463196 @default.
• W1567192062 hasRelatedWork W4213315268 @default.

• next