FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567198375> ?p ?o ?g. }

• W1567198375 endingPage "1139" @default.
• W1567198375 startingPage "1130" @default.
• W1567198375 abstract "Background and Purpose Eicosapentaenoic acid (EPA) has been shown to suppress immune cell responses, such as cytokine production and downstream PG production in vitro. Studies in vivo, however, have used EPA as a minor constituent of fish oil with variable results. We investigated the effects of EPA on systemic inflammatory responses as pure EPA has not been evaluated on immune/inflammatory responses in vivo. Experimental Approach Rabbits were administered polyinosinic: polycytidylic acid (poly I:C) i.v. before and after oral treatment with EPA for 42 days (given daily). The responses to IL-1β and TNF-α were also studied. Immediately following administration of poly I:C, body temperature was continuously monitored and blood samples were taken. Plasma levels of IL-1β, PGE2 (PGE2), and 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) were measured by enzyme immunoassay. Key Results Following EPA treatment, the fever response to poly I:C was markedly suppressed compared with pretreatment responses. This was accompanied by a parallel reduction in the poly I:C-stimulated elevation in plasma levels of IL-1β and PGE2. Paradoxically, the levels of 15d-PGJ2 were higher following EPA treatment. EPA treatment did not significantly alter the fever response or plasma levels of PGE2 in response to either IL-1β or TNF-α. Conclusion and Implications Oral treatment with EPA can suppress immune/inflammatory responses in vivo via a suppression of upstream cytokine production resulting in a decreased fever response and indirectly reducing circulating levels of PGE2. EPA also enhances the production of the cytoprotective prostanoid 15d-PGJ2 indicating the therapeutic benefit of EPA." @default.
• W1567198375 created "2016-06-24" @default.
• W1567198375 creator A5012410639 @default.
• W1567198375 creator A5017551007 @default.
• W1567198375 creator A5063204123 @default.
• W1567198375 date "2013-06-12" @default.
• W1567198375 modified "2023-09-24" @default.
• W1567198375 title "Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxyΔ^12,14Prostaglandin J₂production" @default.
• W1567198375 cites W1590390900 @default.
• W1567198375 cites W1865786062 @default.
• W1567198375 cites W1896649150 @default.
• W1567198375 cites W1966852699 @default.
• W1567198375 cites W1966934571 @default.
• W1567198375 cites W1967803403 @default.
• W1567198375 cites W1971686414 @default.
• W1567198375 cites W1974686353 @default.
• W1567198375 cites W1986330423 @default.
• W1567198375 cites W2005674716 @default.
• W1567198375 cites W2006574739 @default.
• W1567198375 cites W2011458650 @default.
• W1567198375 cites W2015283169 @default.
• W1567198375 cites W2027651407 @default.
• W1567198375 cites W2034085759 @default.
• W1567198375 cites W2034215339 @default.
• W1567198375 cites W2039700084 @default.
• W1567198375 cites W2039875723 @default.
• W1567198375 cites W2040308284 @default.
• W1567198375 cites W2046375187 @default.
• W1567198375 cites W2047297053 @default.
• W1567198375 cites W2052620776 @default.
• W1567198375 cites W2053486415 @default.
• W1567198375 cites W2054075267 @default.
• W1567198375 cites W2059628979 @default.
• W1567198375 cites W2060043052 @default.
• W1567198375 cites W2063448744 @default.
• W1567198375 cites W2069380892 @default.
• W1567198375 cites W2070977771 @default.
• W1567198375 cites W2072291790 @default.
• W1567198375 cites W2074603347 @default.
• W1567198375 cites W2074702732 @default.
• W1567198375 cites W2079585616 @default.
• W1567198375 cites W2087631918 @default.
• W1567198375 cites W2089585374 @default.
• W1567198375 cites W2095950170 @default.
• W1567198375 cites W2116474837 @default.
• W1567198375 cites W2122656413 @default.
• W1567198375 cites W2128380749 @default.
• W1567198375 cites W2128414599 @default.
• W1567198375 cites W2130711338 @default.
• W1567198375 cites W2138492638 @default.
• W1567198375 cites W2147808249 @default.
• W1567198375 cites W2157204944 @default.
• W1567198375 cites W2158863209 @default.
• W1567198375 cites W2159151045 @default.
• W1567198375 cites W2163134721 @default.
• W1567198375 cites W2169580254 @default.
• W1567198375 cites W4243231383 @default.
• W1567198375 doi "https://doi.org/10.1111/bph.12209" @default.
• W1567198375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696334" @default.
• W1567198375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23586396" @default.
• W1567198375 hasPublicationYear "2013" @default.
• W1567198375 type Work @default.
• W1567198375 sameAs 1567198375 @default.
• W1567198375 citedByCount "11" @default.
• W1567198375 countsByYear W15671983752014 @default.
• W1567198375 countsByYear W15671983752017 @default.
• W1567198375 countsByYear W15671983752018 @default.
• W1567198375 countsByYear W15671983752019 @default.
• W1567198375 countsByYear W15671983752020 @default.
• W1567198375 countsByYear W15671983752022 @default.
• W1567198375 countsByYear W15671983752023 @default.
• W1567198375 crossrefType "journal-article" @default.
• W1567198375 hasAuthorship W1567198375A5012410639 @default.
• W1567198375 hasAuthorship W1567198375A5017551007 @default.
• W1567198375 hasAuthorship W1567198375A5063204123 @default.
• W1567198375 hasBestOaLocation W15671983752 @default.
• W1567198375 hasConcept C126322002 @default.
• W1567198375 hasConcept C134018914 @default.
• W1567198375 hasConcept C150903083 @default.
• W1567198375 hasConcept C17991360 @default.
• W1567198375 hasConcept C181199279 @default.
• W1567198375 hasConcept C185592680 @default.
• W1567198375 hasConcept C19038510 @default.
• W1567198375 hasConcept C202751555 @default.
• W1567198375 hasConcept C203014093 @default.
• W1567198375 hasConcept C207001950 @default.
• W1567198375 hasConcept C26291073 @default.
• W1567198375 hasConcept C2776091944 @default.
• W1567198375 hasConcept C2776352991 @default.
• W1567198375 hasConcept C2777956040 @default.
• W1567198375 hasConcept C2778078955 @default.
• W1567198375 hasConcept C2778690821 @default.
• W1567198375 hasConcept C2779946292 @default.
• W1567198375 hasConcept C2780664492 @default.
• W1567198375 hasConcept C2909208804 @default.
• W1567198375 hasConcept C505870484 @default.
• W1567198375 hasConcept C543025807 @default.
• W1567198375 hasConcept C55493867 @default.

• next