Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567203104> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1567203104 endingPage "57" @default.
- W1567203104 startingPage "49" @default.
- W1567203104 abstract "Two different mechanisms of murine macrophage (MP) antitumor activity are described in this report. C. parvum-activated peritoneal MPs were tested for cytotoxic and cytostatic activity 4 days after ip immunization. Cytotoxic activity could be distinguished from cytostatic activity using two different assay protocols. When MPs were separated by 1g velocity sedimentation, cytotoxic MPs were confined to high velocity fractions. In contrast, cytostatic MPs were found in cell fractions with velocities as low as 5.2 mm/hr. These two MP activities were also distinguishable by culturing at 37 degrees C for 24 hr. Cytotoxicity was abrogated when MPs were incubated in MEM, or MEM supplemented with lymphokine (LK) or indomethacin. In contrast, cytostasis remained at high levels when the cells were incubated with LK or indomethacin. Cytotoxicity was not retained after overnight culture even if LPS was present, or if various spleen or non-adherent peritoneal exudate cells were cocultured with the cytotoxic effector cells. Assays done to determine the presence of suppressor cells failed to find any inhibitory cell type. The phagocytic index, acid phosphatase activity, and H2O2 secretion were also measured before and after overnight culture. Acid phosphatase and phagocytic activities did not decline whereas H2O2 secretion declined significantly. These data indicate that in response to C. parvum, at least two different effector cell types with distinct antitumor activities are generated. Cytotoxicity, like the ability of cells to secrete H2O2, is found to be a short-lived function of CP stimulated MPs. In contrast, cytostasis is a function retained longer by MPs in culture." @default.
- W1567203104 created "2016-06-24" @default.
- W1567203104 creator A5019529854 @default.
- W1567203104 creator A5088698561 @default.
- W1567203104 date "1983-02-01" @default.
- W1567203104 modified "2023-09-26" @default.
- W1567203104 title "Role of Corynebacterium parvum in the activation of peritoneal macrophages" @default.
- W1567203104 cites W1504382629 @default.
- W1567203104 cites W1526644990 @default.
- W1567203104 cites W1578811283 @default.
- W1567203104 cites W1957020011 @default.
- W1567203104 cites W1968974831 @default.
- W1567203104 cites W1975359920 @default.
- W1567203104 cites W1993468175 @default.
- W1567203104 cites W2003486557 @default.
- W1567203104 cites W2044027929 @default.
- W1567203104 cites W2069078839 @default.
- W1567203104 cites W2086899712 @default.
- W1567203104 cites W2089813543 @default.
- W1567203104 cites W2097137141 @default.
- W1567203104 cites W2111047750 @default.
- W1567203104 cites W2126613105 @default.
- W1567203104 cites W2153521314 @default.
- W1567203104 cites W2415504776 @default.
- W1567203104 doi "https://doi.org/10.1016/0008-8749(83)90347-7" @default.
- W1567203104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6219754" @default.
- W1567203104 hasPublicationYear "1983" @default.
- W1567203104 type Work @default.
- W1567203104 sameAs 1567203104 @default.
- W1567203104 citedByCount "26" @default.
- W1567203104 crossrefType "journal-article" @default.
- W1567203104 hasAuthorship W1567203104A5019529854 @default.
- W1567203104 hasAuthorship W1567203104A5088698561 @default.
- W1567203104 hasConcept C109316439 @default.
- W1567203104 hasConcept C153911025 @default.
- W1567203104 hasConcept C154317977 @default.
- W1567203104 hasConcept C181199279 @default.
- W1567203104 hasConcept C182547069 @default.
- W1567203104 hasConcept C202751555 @default.
- W1567203104 hasConcept C203014093 @default.
- W1567203104 hasConcept C21547065 @default.
- W1567203104 hasConcept C49039625 @default.
- W1567203104 hasConcept C51785407 @default.
- W1567203104 hasConcept C54355233 @default.
- W1567203104 hasConcept C55493867 @default.
- W1567203104 hasConcept C81885089 @default.
- W1567203104 hasConcept C86803240 @default.
- W1567203104 hasConcept C89423630 @default.
- W1567203104 hasConceptScore W1567203104C109316439 @default.
- W1567203104 hasConceptScore W1567203104C153911025 @default.
- W1567203104 hasConceptScore W1567203104C154317977 @default.
- W1567203104 hasConceptScore W1567203104C181199279 @default.
- W1567203104 hasConceptScore W1567203104C182547069 @default.
- W1567203104 hasConceptScore W1567203104C202751555 @default.
- W1567203104 hasConceptScore W1567203104C203014093 @default.
- W1567203104 hasConceptScore W1567203104C21547065 @default.
- W1567203104 hasConceptScore W1567203104C49039625 @default.
- W1567203104 hasConceptScore W1567203104C51785407 @default.
- W1567203104 hasConceptScore W1567203104C54355233 @default.
- W1567203104 hasConceptScore W1567203104C55493867 @default.
- W1567203104 hasConceptScore W1567203104C81885089 @default.
- W1567203104 hasConceptScore W1567203104C86803240 @default.
- W1567203104 hasConceptScore W1567203104C89423630 @default.
- W1567203104 hasIssue "1" @default.
- W1567203104 hasLocation W15672031041 @default.
- W1567203104 hasLocation W15672031042 @default.
- W1567203104 hasOpenAccess W1567203104 @default.
- W1567203104 hasPrimaryLocation W15672031041 @default.
- W1567203104 hasRelatedWork W1510491161 @default.
- W1567203104 hasRelatedWork W1543053641 @default.
- W1567203104 hasRelatedWork W1567203104 @default.
- W1567203104 hasRelatedWork W1817861454 @default.
- W1567203104 hasRelatedWork W2081647556 @default.
- W1567203104 hasRelatedWork W2100079462 @default.
- W1567203104 hasRelatedWork W2147687000 @default.
- W1567203104 hasRelatedWork W2149077151 @default.
- W1567203104 hasRelatedWork W2415767386 @default.
- W1567203104 hasRelatedWork W267618195 @default.
- W1567203104 hasVolume "76" @default.
- W1567203104 isParatext "false" @default.
- W1567203104 isRetracted "false" @default.
- W1567203104 magId "1567203104" @default.
- W1567203104 workType "article" @default.