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- W156720329 abstract "The regulatory role of hormones and growth factors on glial cell development has been demonstrated in several studies (1–3). Hormones also influence the aging of glial cells and their role in the aging brain (4). In early reports, the gliosis that occurred in the brain of aged animals consisted primarily of astrocytes and oligodendrocytes and was interpreted as a compensatory response to the diminishing structural integrity and functional competence of neurons and their increasing pathology (5,6). The stimulatory effects of thyroid hormones on development and adult function of glial cells are numerous and well established (4,7). Endocrine-glia interactions may support normal function of neurons and repair damage of central nervous system (CNS) regions. The current view is that neurons may regenerate not only during development but also in adulthood, and not only in laboratory animals but also in humans (8-10). The “post-developmental” CNS may not be “as hostile an environment for the regeneration of neuronal networks as once believed” (10) and it may be induced to regenerate by internal influences (8). As glial cells are an important component of the neuronal microenvironment, they may represent a key factor for CNS repair after injury or in prevention and treatment of neurodegenerative diseases." @default.
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- W156720329 date "2002-01-01" @default.
- W156720329 modified "2023-09-23" @default.
- W156720329 title "Effects of Estrogens and Thyroid Hormone on Development and Aging of Astrocytes and Oligodendrocytes" @default.
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- W156720329 doi "https://doi.org/10.1007/978-1-59259-105-3_13" @default.
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