Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567208048> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1567208048 abstract "Background: Cardiac hypertrophy is a multiple response to physiological and pathological stimuli and an important risk factor for heart failure. The aim of this current study was to examine the effect of EGFR inhibitors on Ang II-induced cardiac hypertrophy and further identify the underlying cellular/molecular mechanisms in Ang II/EGFR-involved cardiac hypertrophy pathway. Methods: In vitro cultured rat H9C2 cells were induced hypertrophy by AngII. C57BL/6 mice were given a subcutaneous injection of AngII for two weeks and simultaneously were treated with EGFR inhibitors by daily gavage. Result: Stimulation of either Ang II or EGF significantly activated EGFR pathway and increased EGFR, AKT and ERK phosphorylation, while these increases were dose-dependently inhibited by EGFR inhibitors. In the meantime, EGFR inhibitors attenuated Ang II-mediated cardiac hypertrophy. Oral administration with small molecule EGFR inhibitors also decreased the cardiac hypertrophy and dysfuncti on in Ang II-treated mice. Finally, the results showed that Ang II-induced EGFR activation was mediated by Src phosphorylation. Conclusion: EGFR plays an important role in Ang II-induced cardiac hypertrophy in vitro and in vivo, and inhibition of EGFR by specific molecules may be an effective strategy for the treatment of Ang II-associated cardiac diseases. Grant Funding Source: China national science foundation" @default.
- W1567208048 created "2016-06-24" @default.
- W1567208048 creator A5003490424 @default.
- W1567208048 creator A5049093184 @default.
- W1567208048 creator A5085379977 @default.
- W1567208048 date "2014-04-01" @default.
- W1567208048 modified "2023-09-27" @default.
- W1567208048 title "Novel EGFR inhibitors attenuate Ang II‐induced cardiac hypertrophy (794.3)" @default.
- W1567208048 doi "https://doi.org/10.1096/fasebj.28.1_supplement.794.3" @default.
- W1567208048 hasPublicationYear "2014" @default.
- W1567208048 type Work @default.
- W1567208048 sameAs 1567208048 @default.
- W1567208048 citedByCount "0" @default.
- W1567208048 crossrefType "journal-article" @default.
- W1567208048 hasAuthorship W1567208048A5003490424 @default.
- W1567208048 hasAuthorship W1567208048A5049093184 @default.
- W1567208048 hasAuthorship W1567208048A5085379977 @default.
- W1567208048 hasConcept C111566952 @default.
- W1567208048 hasConcept C11960822 @default.
- W1567208048 hasConcept C121608353 @default.
- W1567208048 hasConcept C126322002 @default.
- W1567208048 hasConcept C134018914 @default.
- W1567208048 hasConcept C150903083 @default.
- W1567208048 hasConcept C167414201 @default.
- W1567208048 hasConcept C185592680 @default.
- W1567208048 hasConcept C207001950 @default.
- W1567208048 hasConcept C24998067 @default.
- W1567208048 hasConcept C2777506169 @default.
- W1567208048 hasConcept C2778198053 @default.
- W1567208048 hasConcept C2779438470 @default.
- W1567208048 hasConcept C3018791406 @default.
- W1567208048 hasConcept C502942594 @default.
- W1567208048 hasConcept C55493867 @default.
- W1567208048 hasConcept C57074206 @default.
- W1567208048 hasConcept C71924100 @default.
- W1567208048 hasConcept C75217442 @default.
- W1567208048 hasConcept C86803240 @default.
- W1567208048 hasConcept C98274493 @default.
- W1567208048 hasConceptScore W1567208048C111566952 @default.
- W1567208048 hasConceptScore W1567208048C11960822 @default.
- W1567208048 hasConceptScore W1567208048C121608353 @default.
- W1567208048 hasConceptScore W1567208048C126322002 @default.
- W1567208048 hasConceptScore W1567208048C134018914 @default.
- W1567208048 hasConceptScore W1567208048C150903083 @default.
- W1567208048 hasConceptScore W1567208048C167414201 @default.
- W1567208048 hasConceptScore W1567208048C185592680 @default.
- W1567208048 hasConceptScore W1567208048C207001950 @default.
- W1567208048 hasConceptScore W1567208048C24998067 @default.
- W1567208048 hasConceptScore W1567208048C2777506169 @default.
- W1567208048 hasConceptScore W1567208048C2778198053 @default.
- W1567208048 hasConceptScore W1567208048C2779438470 @default.
- W1567208048 hasConceptScore W1567208048C3018791406 @default.
- W1567208048 hasConceptScore W1567208048C502942594 @default.
- W1567208048 hasConceptScore W1567208048C55493867 @default.
- W1567208048 hasConceptScore W1567208048C57074206 @default.
- W1567208048 hasConceptScore W1567208048C71924100 @default.
- W1567208048 hasConceptScore W1567208048C75217442 @default.
- W1567208048 hasConceptScore W1567208048C86803240 @default.
- W1567208048 hasConceptScore W1567208048C98274493 @default.
- W1567208048 hasIssue "S1" @default.
- W1567208048 hasLocation W15672080481 @default.
- W1567208048 hasOpenAccess W1567208048 @default.
- W1567208048 hasPrimaryLocation W15672080481 @default.
- W1567208048 hasRelatedWork W1514902666 @default.
- W1567208048 hasRelatedWork W2011726134 @default.
- W1567208048 hasRelatedWork W2023977540 @default.
- W1567208048 hasRelatedWork W2128452890 @default.
- W1567208048 hasRelatedWork W2319446260 @default.
- W1567208048 hasRelatedWork W2581581719 @default.
- W1567208048 hasRelatedWork W3041606144 @default.
- W1567208048 hasRelatedWork W3160140598 @default.
- W1567208048 hasRelatedWork W4319032158 @default.
- W1567208048 hasRelatedWork W2185356304 @default.
- W1567208048 hasVolume "28" @default.
- W1567208048 isParatext "false" @default.
- W1567208048 isRetracted "false" @default.
- W1567208048 magId "1567208048" @default.
- W1567208048 workType "article" @default.