Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567211083> ?p ?o ?g. }
- W1567211083 endingPage "2014" @default.
- W1567211083 startingPage "2003" @default.
- W1567211083 abstract "Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is problematic due to the inability to control the MSCs' commitment, growth, and differentiation into functional osteoblasts on the bone surface. Our research group has developed a method to direct the MSCs to the bone surface by conjugating a synthetic peptidomimetic ligand (LLP2A) that has high affinity for activated α4β1 integrin on the MSC surface, with a bisphosphonates (alendronate) that has high affinity for bone (LLP2A-Ale), to direct the transplanted MSCs to bone. Our in vitro experiments demonstrated that mobilization of LLP2A-Ale to hydroxyapatite accelerated MSC migration that was associated with an increase in the phosphorylation of Akt kinase and osteoblastogenesis. LLP2A-Ale increased the homing of the transplanted MSCs to bone as well as the osteoblast surface, significantly increased the rate of bone formation and restored both trabecular and cortical bone loss induced by estrogen deficiency or advanced age in mice. These results support LLP2A-Ale as a novel therapeutic option to direct the transplanted MSCs to bone for the treatment of established bone loss related to hormone deficiency and aging." @default.
- W1567211083 created "2016-06-24" @default.
- W1567211083 creator A5013023637 @default.
- W1567211083 creator A5013414619 @default.
- W1567211083 creator A5016566536 @default.
- W1567211083 creator A5023863572 @default.
- W1567211083 creator A5034751387 @default.
- W1567211083 creator A5041988083 @default.
- W1567211083 creator A5042863895 @default.
- W1567211083 creator A5047348370 @default.
- W1567211083 creator A5048894863 @default.
- W1567211083 creator A5056890445 @default.
- W1567211083 creator A5065066504 @default.
- W1567211083 creator A5065353448 @default.
- W1567211083 creator A5075246076 @default.
- W1567211083 creator A5089959628 @default.
- W1567211083 date "2013-09-01" @default.
- W1567211083 modified "2023-10-10" @default.
- W1567211083 title "Reversing bone loss by directing mesenchymal stem cells to bone" @default.
- W1567211083 cites W1555276708 @default.
- W1567211083 cites W1590090819 @default.
- W1567211083 cites W1757602702 @default.
- W1567211083 cites W1967217261 @default.
- W1567211083 cites W1974877803 @default.
- W1567211083 cites W1975255476 @default.
- W1567211083 cites W1976152802 @default.
- W1567211083 cites W1976479369 @default.
- W1567211083 cites W1977921602 @default.
- W1567211083 cites W1978993910 @default.
- W1567211083 cites W1982174586 @default.
- W1567211083 cites W1983220846 @default.
- W1567211083 cites W1983902360 @default.
- W1567211083 cites W1985048736 @default.
- W1567211083 cites W1985366897 @default.
- W1567211083 cites W1986544619 @default.
- W1567211083 cites W1992104196 @default.
- W1567211083 cites W1992786647 @default.
- W1567211083 cites W1996092483 @default.
- W1567211083 cites W1998111806 @default.
- W1567211083 cites W1999360673 @default.
- W1567211083 cites W2001582495 @default.
- W1567211083 cites W2002045948 @default.
- W1567211083 cites W2002438043 @default.
- W1567211083 cites W2010999937 @default.
- W1567211083 cites W2014892893 @default.
- W1567211083 cites W2016409488 @default.
- W1567211083 cites W2021829493 @default.
- W1567211083 cites W2022055461 @default.
- W1567211083 cites W2024326908 @default.
- W1567211083 cites W2030805338 @default.
- W1567211083 cites W2031751222 @default.
- W1567211083 cites W2031930652 @default.
- W1567211083 cites W2041863225 @default.
- W1567211083 cites W2045080708 @default.
- W1567211083 cites W2051922866 @default.
- W1567211083 cites W2054635074 @default.
- W1567211083 cites W2056725513 @default.
- W1567211083 cites W2060134459 @default.
- W1567211083 cites W2062111150 @default.
- W1567211083 cites W2064748674 @default.
- W1567211083 cites W2067903474 @default.
- W1567211083 cites W2075886483 @default.
- W1567211083 cites W2075942291 @default.
- W1567211083 cites W2084395631 @default.
- W1567211083 cites W2096425957 @default.
- W1567211083 cites W2097675424 @default.
- W1567211083 cites W2098234683 @default.
- W1567211083 cites W2105110066 @default.
- W1567211083 cites W2110148884 @default.
- W1567211083 cites W2121299956 @default.
- W1567211083 cites W2126134953 @default.
- W1567211083 cites W2126434849 @default.
- W1567211083 cites W2134208433 @default.
- W1567211083 cites W2140562350 @default.
- W1567211083 cites W2142900141 @default.
- W1567211083 cites W2149414710 @default.
- W1567211083 cites W2152377475 @default.
- W1567211083 cites W2159869836 @default.
- W1567211083 cites W2159999899 @default.
- W1567211083 cites W2162412444 @default.
- W1567211083 cites W2171828133 @default.
- W1567211083 doi "https://doi.org/10.1002/stem.1461" @default.
- W1567211083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3795809" @default.
- W1567211083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23818248" @default.
- W1567211083 hasPublicationYear "2013" @default.
- W1567211083 type Work @default.
- W1567211083 sameAs 1567211083 @default.
- W1567211083 citedByCount "76" @default.
- W1567211083 countsByYear W15672110832013 @default.
- W1567211083 countsByYear W15672110832014 @default.
- W1567211083 countsByYear W15672110832015 @default.
- W1567211083 countsByYear W15672110832016 @default.
- W1567211083 countsByYear W15672110832017 @default.
- W1567211083 countsByYear W15672110832018 @default.
- W1567211083 countsByYear W15672110832019 @default.
- W1567211083 countsByYear W15672110832020 @default.
- W1567211083 countsByYear W15672110832021 @default.
- W1567211083 countsByYear W15672110832022 @default.