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- W1567211141 abstract "Primary human tumor culture models allow for individualized drug sensitivity testing and are therefore a promising technique to achieve personalized treatment for cancer patients. This would especially be of interest for patients with advanced stage head and neck cancer. They are extensively treated with surgery, usually in combination with high-dose cisplatin chemoradiation. However, adding cisplatin to radiotherapy is associated with an increase in severe acute toxicity, while conferring only a minor overall survival benefit. Hence, there is a strong need for a preclinical model to identify patients that will respond to the intended treatment regimen and to test novel drugs. One of such models is the technique of culturing primary human tumor tissue. This review discusses the feasibility and success rate of existing primary head and neck tumor culturing techniques and their corresponding chemo- and radiosensitivity assays. A comprehensive literature search was performed and success factors for culturing in vitro are debated, together with the actual value of these models as preclinical prediction assay for individual patients. With this review, we aim to fill a gap in the understanding of primary culture models from head and neck tumors, with potential importance for other tumor types as well." @default.
- W1567211141 created "2016-06-24" @default.
- W1567211141 creator A5000794664 @default.
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- W1567211141 creator A5063155328 @default.
- W1567211141 creator A5064418188 @default.
- W1567211141 date "2015-08-28" @default.
- W1567211141 modified "2023-09-26" @default.
- W1567211141 title "Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review" @default.
- W1567211141 cites W1503724923 @default.
- W1567211141 cites W1506139159 @default.
- W1567211141 cites W1508579127 @default.
- W1567211141 cites W1516733234 @default.
- W1567211141 cites W1571752401 @default.
- W1567211141 cites W1582186877 @default.
- W1567211141 cites W1612393989 @default.
- W1567211141 cites W1882622037 @default.
- W1567211141 cites W1932907383 @default.
- W1567211141 cites W1953828328 @default.
- W1567211141 cites W1966554609 @default.
- W1567211141 cites W1966756830 @default.
- W1567211141 cites W1967338954 @default.
- W1567211141 cites W1969382080 @default.
- W1567211141 cites W1975804993 @default.
- W1567211141 cites W1976934485 @default.
- W1567211141 cites W1977507349 @default.
- W1567211141 cites W1979085290 @default.
- W1567211141 cites W1979967176 @default.
- W1567211141 cites W1980056924 @default.
- W1567211141 cites W1981406681 @default.
- W1567211141 cites W1985364084 @default.
- W1567211141 cites W1986234577 @default.
- W1567211141 cites W1986255777 @default.
- W1567211141 cites W1987680912 @default.
- W1567211141 cites W1989100557 @default.
- W1567211141 cites W1990760723 @default.
- W1567211141 cites W1991283366 @default.
- W1567211141 cites W1992022488 @default.
- W1567211141 cites W1992216513 @default.
- W1567211141 cites W1992437224 @default.
- W1567211141 cites W1993082044 @default.
- W1567211141 cites W1994553203 @default.
- W1567211141 cites W1995609011 @default.
- W1567211141 cites W1999988680 @default.
- W1567211141 cites W2002305721 @default.
- W1567211141 cites W2003434061 @default.
- W1567211141 cites W2007002229 @default.
- W1567211141 cites W2007911155 @default.
- W1567211141 cites W2012802186 @default.
- W1567211141 cites W2016564881 @default.
- W1567211141 cites W2017256577 @default.
- W1567211141 cites W2020061207 @default.
- W1567211141 cites W2021247307 @default.
- W1567211141 cites W2023067707 @default.
- W1567211141 cites W2023300542 @default.
- W1567211141 cites W2025302032 @default.
- W1567211141 cites W2026182412 @default.
- W1567211141 cites W2027315761 @default.
- W1567211141 cites W2034281671 @default.
- W1567211141 cites W2034644819 @default.
- W1567211141 cites W2036005555 @default.
- W1567211141 cites W2037918022 @default.
- W1567211141 cites W2038531943 @default.
- W1567211141 cites W2042831183 @default.
- W1567211141 cites W2047350520 @default.
- W1567211141 cites W2048970994 @default.
- W1567211141 cites W2053095296 @default.
- W1567211141 cites W2056419915 @default.
- W1567211141 cites W2059696502 @default.
- W1567211141 cites W2060199208 @default.
- W1567211141 cites W2060800107 @default.
- W1567211141 cites W2072608181 @default.
- W1567211141 cites W2082130460 @default.
- W1567211141 cites W2083254800 @default.
- W1567211141 cites W2087703581 @default.
- W1567211141 cites W2089257078 @default.
- W1567211141 cites W2092419869 @default.
- W1567211141 cites W2093733030 @default.
- W1567211141 cites W2101636707 @default.
- W1567211141 cites W2103494397 @default.
- W1567211141 cites W2107263674 @default.
- W1567211141 cites W2108618198 @default.
- W1567211141 cites W2116131597 @default.
- W1567211141 cites W2119912961 @default.
- W1567211141 cites W2124363070 @default.
- W1567211141 cites W2127605299 @default.
- W1567211141 cites W2128202926 @default.
- W1567211141 cites W2128895905 @default.
- W1567211141 cites W2133541913 @default.
- W1567211141 cites W2140753782 @default.
- W1567211141 cites W2143551581 @default.
- W1567211141 cites W2145981915 @default.
- W1567211141 cites W2156487088 @default.
- W1567211141 cites W2159195088 @default.
- W1567211141 cites W2162762738 @default.