Matches in SemOpenAlex for { <https://semopenalex.org/work/W156721580> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W156721580 endingPage "43" @default.
- W156721580 startingPage "13" @default.
- W156721580 abstract "Hematopoietic damage following treatment with certain medications remains a major problem of drug therapy. As long as drugs remain indispensable in the treatment of disease, this problem cannot be resolved simply by avoiding their use. Instead, development of information that pertains to the mechanism and prediction of drug-induced blood dyscrasias must be acquired for the safe use of drugs. Forewarned is forearmed; if it were possible to identify a susceptible patient or a potentially dangerous drug, then the potential risk of producing a serious blood re action with treatment would be minimized. A precedent for this concept was established with the discovery that patients whose erythrocytes are deficient in glucose-6-phosphate dehydrogenase are unusually susceptible to hemolytic anemia if treated with oxidant drugs.41 For most of the other toxic blood dyscrasias, knowledge of the pathogenesis remains obscure because certain difficulties limit acquisition of such information. The mechanisms of a drug reaction produced by one drug may differ from that produced by another drug. Also, the rare incidence of druginduced blood dyscrasias has made very few patients available for studies. Few papers have appeared which deal with the mechanism of drug-induced hematopoietic disease. In addition, the difficulties entailed in obtaining bone marrow and other specimens in sufficient quantity has restricted effective investigation. Since the technique required to study mechanisms of drug reactions may be complex and expensive, it may be logistically unsound for a laboratory to “tool up” and then sit back and wait for the first patient to arrive." @default.
- W156721580 created "2016-06-24" @default.
- W156721580 creator A5005017533 @default.
- W156721580 date "1971-01-01" @default.
- W156721580 modified "2023-09-24" @default.
- W156721580 title "Drug-induced leukopenia and aplastic anemia" @default.
- W156721580 doi "https://doi.org/10.1002/cpt197112113" @default.
- W156721580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4927148" @default.
- W156721580 hasPublicationYear "1971" @default.
- W156721580 type Work @default.
- W156721580 sameAs 156721580 @default.
- W156721580 citedByCount "54" @default.
- W156721580 countsByYear W1567215802012 @default.
- W156721580 countsByYear W1567215802019 @default.
- W156721580 countsByYear W1567215802022 @default.
- W156721580 crossrefType "journal-article" @default.
- W156721580 hasAuthorship W156721580A5005017533 @default.
- W156721580 hasConcept C109159458 @default.
- W156721580 hasConcept C113775271 @default.
- W156721580 hasConcept C126322002 @default.
- W156721580 hasConcept C141071460 @default.
- W156721580 hasConcept C177713679 @default.
- W156721580 hasConcept C203014093 @default.
- W156721580 hasConcept C2776396001 @default.
- W156721580 hasConcept C2776694085 @default.
- W156721580 hasConcept C2778248108 @default.
- W156721580 hasConcept C2779134260 @default.
- W156721580 hasConcept C2780007613 @default.
- W156721580 hasConcept C2780035454 @default.
- W156721580 hasConcept C2780873365 @default.
- W156721580 hasConcept C2781440808 @default.
- W156721580 hasConcept C28328180 @default.
- W156721580 hasConcept C54355233 @default.
- W156721580 hasConcept C71924100 @default.
- W156721580 hasConcept C86803240 @default.
- W156721580 hasConcept C98274493 @default.
- W156721580 hasConceptScore W156721580C109159458 @default.
- W156721580 hasConceptScore W156721580C113775271 @default.
- W156721580 hasConceptScore W156721580C126322002 @default.
- W156721580 hasConceptScore W156721580C141071460 @default.
- W156721580 hasConceptScore W156721580C177713679 @default.
- W156721580 hasConceptScore W156721580C203014093 @default.
- W156721580 hasConceptScore W156721580C2776396001 @default.
- W156721580 hasConceptScore W156721580C2776694085 @default.
- W156721580 hasConceptScore W156721580C2778248108 @default.
- W156721580 hasConceptScore W156721580C2779134260 @default.
- W156721580 hasConceptScore W156721580C2780007613 @default.
- W156721580 hasConceptScore W156721580C2780035454 @default.
- W156721580 hasConceptScore W156721580C2780873365 @default.
- W156721580 hasConceptScore W156721580C2781440808 @default.
- W156721580 hasConceptScore W156721580C28328180 @default.
- W156721580 hasConceptScore W156721580C54355233 @default.
- W156721580 hasConceptScore W156721580C71924100 @default.
- W156721580 hasConceptScore W156721580C86803240 @default.
- W156721580 hasConceptScore W156721580C98274493 @default.
- W156721580 hasIssue "1" @default.
- W156721580 hasLocation W1567215801 @default.
- W156721580 hasLocation W1567215802 @default.
- W156721580 hasOpenAccess W156721580 @default.
- W156721580 hasPrimaryLocation W1567215801 @default.
- W156721580 hasRelatedWork W141706179 @default.
- W156721580 hasRelatedWork W156721580 @default.
- W156721580 hasRelatedWork W1983264920 @default.
- W156721580 hasRelatedWork W2067301395 @default.
- W156721580 hasRelatedWork W2124886470 @default.
- W156721580 hasRelatedWork W2156670244 @default.
- W156721580 hasRelatedWork W2396323476 @default.
- W156721580 hasRelatedWork W2413202312 @default.
- W156721580 hasRelatedWork W2425351335 @default.
- W156721580 hasRelatedWork W4239872221 @default.
- W156721580 hasVolume "12" @default.
- W156721580 isParatext "false" @default.
- W156721580 isRetracted "false" @default.
- W156721580 magId "156721580" @default.
- W156721580 workType "article" @default.