Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567224629> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1567224629 abstract "Introduction: Vectorcardiography (VCG) has clinical prognostic and diagnostic value in various disease states. Hypertrophic cardiomyopathy is a disease state which can lead to sudden cardiac death, where genotype status has been shown to predict worse outcomes.. Hypothesis: We set out to determine the utility of vectorcardiographic parameters in one of the largest genotyped cohorts of patients with hypertrophic cardiomyopathy (HCM) and to determine whether they can identify genotype status. Methods: Between 1997 and 2007, research based genetic testing was performed on 1053 patients with HCM (60% males; mean age at diagnosis 44.4 years); yield of genetic testing was 34%. Of these, 967 had ECG’s appropriate for computerized derivation of VCG parameters including the spatial mean and peaks QRS-T angles, spatial ventricular gradient and the spatial QRS, QT, and Tpeak-Tend (TpTe) intervals. Results were compared against those from a group of healthy control subjects (N=418).Subsequent genotype positive versus negative comparisons were performed using paired student T-tests or Mann-Whitney U-tests as appropriate. Results: Spatial peaks and spatial mean QRS-T angles were significantly higher in HCM patients (129.3±26.4 and 121.8±38.6 degrees, respectively) than in controls (25.0±15.0 and 43.0±-21.0 degrees, respectively, p<0.001). Sensitivities for HCM, based on cutoff values of 2 standard deviations above the mean values reported for control patients, were 84.5% and 81.5% for spatial peaks and spatial mean QRS-T angles, respectively. VCG predicted genotype status as genotype positive patients had significantly higher spatial peaks (132.4±-29.2 vs. 127.9±24.8 degrees; p = 0.02) and spatial mean (129.7±33.8 vs. 117.6±40.3 degrees; p<0.001) QRS-T angles, spatial TpTe (118.0±40.8 vs. 107.9±48.7 ms; p<0.001) as well as significantly lower spatial ventricular gradients (0.059±0.044 vs. 0.067±0.04; p<0.001). Conclusions: Patients with HCM can be distinguished from normal subjects through the study of the spatial QRS-T angle. Whether incorporation of spatial peaks QRS-T angle to pre-existing genetic test prediction tools will further improve prediction of genotype status remains to be determined." @default.
- W1567224629 created "2016-06-24" @default.
- W1567224629 creator A5004431286 @default.
- W1567224629 creator A5055125250 @default.
- W1567224629 creator A5057798904 @default.
- W1567224629 creator A5091712092 @default.
- W1567224629 date "2014-11-25" @default.
- W1567224629 modified "2023-09-27" @default.
- W1567224629 title "Abstract 11981: ECG-Derived Vectorcardiography Identifies Disease and Genotype Status in Hypertrophic Cardiomyopathy" @default.
- W1567224629 doi "https://doi.org/10.1161/circ.130.suppl_2.11981" @default.
- W1567224629 hasPublicationYear "2014" @default.
- W1567224629 type Work @default.
- W1567224629 sameAs 1567224629 @default.
- W1567224629 citedByCount "1" @default.
- W1567224629 countsByYear W15672246292016 @default.
- W1567224629 crossrefType "journal-article" @default.
- W1567224629 hasAuthorship W1567224629A5004431286 @default.
- W1567224629 hasAuthorship W1567224629A5055125250 @default.
- W1567224629 hasAuthorship W1567224629A5057798904 @default.
- W1567224629 hasAuthorship W1567224629A5091712092 @default.
- W1567224629 hasConcept C111773187 @default.
- W1567224629 hasConcept C126322002 @default.
- W1567224629 hasConcept C164705383 @default.
- W1567224629 hasConcept C2775935837 @default.
- W1567224629 hasConcept C2778198053 @default.
- W1567224629 hasConcept C2778797674 @default.
- W1567224629 hasConcept C2780040984 @default.
- W1567224629 hasConcept C2780185194 @default.
- W1567224629 hasConcept C2780486913 @default.
- W1567224629 hasConcept C71924100 @default.
- W1567224629 hasConceptScore W1567224629C111773187 @default.
- W1567224629 hasConceptScore W1567224629C126322002 @default.
- W1567224629 hasConceptScore W1567224629C164705383 @default.
- W1567224629 hasConceptScore W1567224629C2775935837 @default.
- W1567224629 hasConceptScore W1567224629C2778198053 @default.
- W1567224629 hasConceptScore W1567224629C2778797674 @default.
- W1567224629 hasConceptScore W1567224629C2780040984 @default.
- W1567224629 hasConceptScore W1567224629C2780185194 @default.
- W1567224629 hasConceptScore W1567224629C2780486913 @default.
- W1567224629 hasConceptScore W1567224629C71924100 @default.
- W1567224629 hasLocation W15672246291 @default.
- W1567224629 hasOpenAccess W1567224629 @default.
- W1567224629 hasPrimaryLocation W15672246291 @default.
- W1567224629 hasRelatedWork W1548430216 @default.
- W1567224629 hasRelatedWork W1970450470 @default.
- W1567224629 hasRelatedWork W2062094134 @default.
- W1567224629 hasRelatedWork W2103913283 @default.
- W1567224629 hasRelatedWork W2133181744 @default.
- W1567224629 hasRelatedWork W2171967519 @default.
- W1567224629 hasRelatedWork W2327826251 @default.
- W1567224629 hasRelatedWork W2331143553 @default.
- W1567224629 hasRelatedWork W2416520055 @default.
- W1567224629 hasRelatedWork W2480512699 @default.
- W1567224629 hasRelatedWork W2537496195 @default.
- W1567224629 hasRelatedWork W275637439 @default.
- W1567224629 hasRelatedWork W2789374978 @default.
- W1567224629 hasRelatedWork W2802029495 @default.
- W1567224629 hasRelatedWork W2888966375 @default.
- W1567224629 hasRelatedWork W2889318809 @default.
- W1567224629 hasRelatedWork W3028248303 @default.
- W1567224629 hasRelatedWork W3128193625 @default.
- W1567224629 hasRelatedWork W3194348931 @default.
- W1567224629 hasRelatedWork W3194993862 @default.
- W1567224629 isParatext "false" @default.
- W1567224629 isRetracted "false" @default.
- W1567224629 magId "1567224629" @default.
- W1567224629 workType "article" @default.