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• W1567232564 abstract "It has been well established by both clinical and autopsy studies that myocardial infarction is much more common in North American white diabetics compared with nondiabetics. In this study the possible interrelationships between myocardial infarcts, diabetes and adipose tissue fatty acids and plasma lipids were studied by comparing diabetics unselected as to the presence or absence of complications with age- and sex-matched nondiabetics. Adipose tissue fatty acids were measured because of the suggested abnormal release of fatty acids from tissue stores in the diabetic. Only palmitic acid of six adipose tissue fatty acids compared in diabetics and nondiabetics was found to be significantly different, and this only in female diabetics, compared to female nondiabetics. The biologic significance of this finding is questionable. The finding of similar linoleic acid values in North American diabetics and nondiabetics suggests that there is no deficiency of linoleic acid in the diabetic adipose tissue stores contributing to the greater incidence of myocardial infarction in this group. Among plasma lipids, no difference was found in comparing plasma cholesterol levels. However, triglycerides (in both male and female diabetics) and lipid phosphorus (in female diabetics) were found to be elevated when compared to levels in nondiabetics. The elevated serum triglycerides in the diabetic group in this study is in keeping with the serum triglyceride levels found in other groups of diabetics who have strikingly different frequencies of myocardial infarction. North American white, North American Negro, and East African diabetics, with a high, intermediate, and low frequency of myocardial infarction respectively showed high, intermediate, and low levels of serum triglyceride. Although the evidence is far from complete, there is at least some reason to believe that plasma lipids are involved in the clotting mechanism. It is possible that the elevated plasma lipids found in this group of diabetics may explain the greater susceptibility to coronary artery thrombosis and myocardial infarction in diabetes." @default.
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• W1567232564 date "1962-08-01" @default.
• W1567232564 modified "2023-10-14" @default.
• W1567232564 title "Chemico-anatomic studies of arteriosclerosis and thrombosis in diabetics" @default.
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• W1567232564 doi "https://doi.org/10.1016/0014-4800(62)90031-x" @default.
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