Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567240791> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1567240791 abstract "OBJECTIVE: Increased glucose 6-phosphate dehydrogenase activity has been demonstrated in heart failure. This study sought to assess myocardial glucose 6-phosphate dehydrogenase activity in retraining of the subpulmonary ventricle of adult goats. METHODS: Eighteen adult goats were divided into three groups: traditional (fixed banding), sham, and intermittent (adjustable banding, daily 12-hour systolic overload). Systolic (70% of systemic pressure) was maintained during a 4-week period. Right ventricle, pulmonary artery and aortic pressures were measured throughout the study. All animals were submitted to echocardiographic and hemodynamic evaluations throughout the protocol. After the study period, the animals were killed for morphological and glucose 6-phosphate dehydrogenase activity assessment. RESULTS: A 55.7% and 36.7% increase occurred in the intermittent and traditional right ventricle masses, respectively, when compared with the sham group (P<0.05), despite less exposure of intermittent group to systolic overload. No significant changes were observed in myocardial water content in the 3 groups (P=0.27). A 37.2% increase was found in right ventricle wall thickness of intermittent group, compared to sham and traditional groups (P<0.05). Right ventricle glucose 6-phosphate dehydrogenase activity was elevated in the traditional group, when compared to sham and intermittent groups (P=0.05). CONCLUSION: Both study groups have developed similar right ventricle hypertrophy, regardless less systolic exposure of intermittent group. Traditional systolic for adult subpulmonary ventricle retraining causes upregulation of myocardial glucose 6-phosphate dehydrogenase activity. It may suggest that the undesirable pathologic systolic overload is influenced by activation of penthose pathway and cytosolic Nicotinamide adenine dinucleotide phosphate availability. This altered energy substrate metabolism can elevate levels of free radicals by Nicotinamide adenine dinucleotide phosphate oxidase, an important mechanism in the pathophysiology of heart failure." @default.
- W1567240791 created "2016-06-24" @default.
- W1567240791 creator A5009175867 @default.
- W1567240791 creator A5013763546 @default.
- W1567240791 creator A5014725918 @default.
- W1567240791 creator A5026396183 @default.
- W1567240791 creator A5048377535 @default.
- W1567240791 creator A5049281002 @default.
- W1567240791 creator A5071527641 @default.
- W1567240791 creator A5088604083 @default.
- W1567240791 date "2013-01-01" @default.
- W1567240791 modified "2023-09-27" @default.
- W1567240791 title "Reversible pulmonary trunk banding. IX. G6PD activity of adult goat myocardium submitted to ventricular retraining" @default.
- W1567240791 cites W1599321131 @default.
- W1567240791 cites W1953419063 @default.
- W1567240791 cites W1972913443 @default.
- W1567240791 cites W1981905227 @default.
- W1567240791 cites W1992217162 @default.
- W1567240791 cites W1997156605 @default.
- W1567240791 cites W2007671598 @default.
- W1567240791 cites W2033767220 @default.
- W1567240791 cites W2044869229 @default.
- W1567240791 cites W2076585010 @default.
- W1567240791 cites W2078075091 @default.
- W1567240791 cites W2101099004 @default.
- W1567240791 cites W2111523875 @default.
- W1567240791 cites W2117580807 @default.
- W1567240791 cites W2127616500 @default.
- W1567240791 cites W2150926180 @default.
- W1567240791 cites W2166031628 @default.
- W1567240791 cites W2401450661 @default.
- W1567240791 cites W2431699283 @default.
- W1567240791 cites W41091024 @default.
- W1567240791 doi "https://doi.org/10.5935/1678-9741.20130079" @default.
- W1567240791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4389439" @default.
- W1567240791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24598953" @default.
- W1567240791 hasPublicationYear "2013" @default.
- W1567240791 type Work @default.
- W1567240791 sameAs 1567240791 @default.
- W1567240791 citedByCount "0" @default.
- W1567240791 crossrefType "journal-article" @default.
- W1567240791 hasAuthorship W1567240791A5009175867 @default.
- W1567240791 hasAuthorship W1567240791A5013763546 @default.
- W1567240791 hasAuthorship W1567240791A5014725918 @default.
- W1567240791 hasAuthorship W1567240791A5026396183 @default.
- W1567240791 hasAuthorship W1567240791A5048377535 @default.
- W1567240791 hasAuthorship W1567240791A5049281002 @default.
- W1567240791 hasAuthorship W1567240791A5071527641 @default.
- W1567240791 hasAuthorship W1567240791A5088604083 @default.
- W1567240791 hasBestOaLocation W15672407911 @default.
- W1567240791 hasConcept C126322002 @default.
- W1567240791 hasConcept C144133560 @default.
- W1567240791 hasConcept C155202549 @default.
- W1567240791 hasConcept C164705383 @default.
- W1567240791 hasConcept C18903297 @default.
- W1567240791 hasConcept C2778712577 @default.
- W1567240791 hasConcept C2780940725 @default.
- W1567240791 hasConcept C2781197403 @default.
- W1567240791 hasConcept C2910747393 @default.
- W1567240791 hasConcept C71924100 @default.
- W1567240791 hasConcept C86803240 @default.
- W1567240791 hasConceptScore W1567240791C126322002 @default.
- W1567240791 hasConceptScore W1567240791C144133560 @default.
- W1567240791 hasConceptScore W1567240791C155202549 @default.
- W1567240791 hasConceptScore W1567240791C164705383 @default.
- W1567240791 hasConceptScore W1567240791C18903297 @default.
- W1567240791 hasConceptScore W1567240791C2778712577 @default.
- W1567240791 hasConceptScore W1567240791C2780940725 @default.
- W1567240791 hasConceptScore W1567240791C2781197403 @default.
- W1567240791 hasConceptScore W1567240791C2910747393 @default.
- W1567240791 hasConceptScore W1567240791C71924100 @default.
- W1567240791 hasConceptScore W1567240791C86803240 @default.
- W1567240791 hasIssue "4" @default.
- W1567240791 hasLocation W15672407911 @default.
- W1567240791 hasLocation W15672407912 @default.
- W1567240791 hasLocation W15672407913 @default.
- W1567240791 hasLocation W15672407914 @default.
- W1567240791 hasLocation W15672407915 @default.
- W1567240791 hasOpenAccess W1567240791 @default.
- W1567240791 hasPrimaryLocation W15672407911 @default.
- W1567240791 hasRelatedWork W1516154642 @default.
- W1567240791 hasRelatedWork W1566335994 @default.
- W1567240791 hasRelatedWork W2007433002 @default.
- W1567240791 hasRelatedWork W2052855677 @default.
- W1567240791 hasRelatedWork W2086033424 @default.
- W1567240791 hasRelatedWork W2381294920 @default.
- W1567240791 hasRelatedWork W2399854909 @default.
- W1567240791 hasRelatedWork W2419369008 @default.
- W1567240791 hasRelatedWork W303196143 @default.
- W1567240791 hasRelatedWork W3145953227 @default.
- W1567240791 hasVolume "28" @default.
- W1567240791 isParatext "false" @default.
- W1567240791 isRetracted "false" @default.
- W1567240791 magId "1567240791" @default.
- W1567240791 workType "article" @default.