FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567242521> ?p ?o ?g. }

• W1567242521 endingPage "80" @default.
• W1567242521 startingPage "71" @default.
• W1567242521 abstract "We previously demonstrated that the difference between 2300h and 0800h TSH response to protirelin (TRH) tests on the same day (ΔΔTSH test) is an improved measure in detecting hypothalamic-pituitary-thyroid (HPT) axis dysregulation in depression. This chronobiological index (1) is reduced in about three quarters of major depressed inpatients, and (2) is normalized after successful antidepressant treatment. In the present study, we examined whether early changes in HPT axis activity during the first 2 weeks of antidepressant treatment could be associated with subsequent outcome.The ΔΔTSH test was performed in 50 drug-free DSM-IV euthyroid major depressed inpatients and 50 hospitalized controls. After 2 weeks of antidepressant treatment the ΔΔTSH test was repeated in all inpatients. Antidepressant response was evaluated after 6 weeks of treatment.At baseline, ΔΔTSH values were significantly lower in patients compared to controls and 38 patients (76%) showed reduced ΔΔTSH values (i.e., <2.5mU/L). After 2 weeks of antidepressant treatment, 20 patients showed ΔΔTSH normalization (among them 18 were subsequent remitters), while 18 patients did not normalize their ΔΔTSH (among them 15 were non-remitters) (p<0.00001). Among the 12 patients who had normal ΔΔTSH values at baseline, 8 out 9 who had still normal values after 2 weeks of treatment were remitters, while the 3 with worsening HPT axis function (i.e., reduced ΔΔTSH value after 2 weeks of treatment) were non-remitters (p<0.02). A logistic regression analysis revealed that ΔΔTSH levels after 2 weeks of treatment could predict the probability of remission (odds ratio [OR]=2.11, 95% confidence interval [CI]=1.31-3.41).Our results suggest that after 2 weeks of antidepressant treatment: (1) chronobiological restoration of the HPT axis activity precedes clinical remission, and (2) alteration of the HPT axis is associated with treatment resistance." @default.
• W1567242521 created "2016-06-24" @default.
• W1567242521 creator A5008830473 @default.
• W1567242521 creator A5024942778 @default.
• W1567242521 creator A5048383270 @default.
• W1567242521 creator A5049742729 @default.
• W1567242521 creator A5049961089 @default.
• W1567242521 creator A5052530763 @default.
• W1567242521 creator A5078409600 @default.
• W1567242521 date "2015-09-01" @default.
• W1567242521 modified "2023-10-13" @default.
• W1567242521 title "Chronobiological hypothalamic–pituitary–thyroid axis status and antidepressant outcome in major depression" @default.
• W1567242521 cites W143584976 @default.
• W1567242521 cites W1623415077 @default.
• W1567242521 cites W1794165588 @default.
• W1567242521 cites W1986112574 @default.
• W1567242521 cites W1986425038 @default.
• W1567242521 cites W1995786343 @default.
• W1567242521 cites W2002765069 @default.
• W1567242521 cites W2008570024 @default.
• W1567242521 cites W202043522 @default.
• W1567242521 cites W2026820556 @default.
• W1567242521 cites W2028086494 @default.
• W1567242521 cites W2032149427 @default.
• W1567242521 cites W2032339359 @default.
• W1567242521 cites W2034701621 @default.
• W1567242521 cites W2038394925 @default.
• W1567242521 cites W2042857129 @default.
• W1567242521 cites W2042944469 @default.
• W1567242521 cites W2062774668 @default.
• W1567242521 cites W2068814879 @default.
• W1567242521 cites W2069418404 @default.
• W1567242521 cites W2075379052 @default.
• W1567242521 cites W2076531653 @default.
• W1567242521 cites W2086045896 @default.
• W1567242521 cites W2087314247 @default.
• W1567242521 cites W2091407410 @default.
• W1567242521 cites W2091837111 @default.
• W1567242521 cites W2100565984 @default.
• W1567242521 cites W2114613490 @default.
• W1567242521 cites W2129202492 @default.
• W1567242521 cites W2131053945 @default.
• W1567242521 cites W2132223780 @default.
• W1567242521 cites W2138314562 @default.
• W1567242521 cites W2152303431 @default.
• W1567242521 cites W2161624699 @default.
• W1567242521 cites W2171672882 @default.
• W1567242521 cites W2413292096 @default.
• W1567242521 cites W4243444383 @default.
• W1567242521 cites W53238672 @default.
• W1567242521 doi "https://doi.org/10.1016/j.psyneuen.2015.05.005" @default.
• W1567242521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26036452" @default.
• W1567242521 hasPublicationYear "2015" @default.
• W1567242521 type Work @default.
• W1567242521 sameAs 1567242521 @default.
• W1567242521 citedByCount "19" @default.
• W1567242521 countsByYear W15672425212017 @default.
• W1567242521 countsByYear W15672425212018 @default.
• W1567242521 countsByYear W15672425212019 @default.
• W1567242521 countsByYear W15672425212020 @default.
• W1567242521 countsByYear W15672425212021 @default.
• W1567242521 countsByYear W15672425212022 @default.
• W1567242521 countsByYear W15672425212023 @default.
• W1567242521 crossrefType "journal-article" @default.
• W1567242521 hasAuthorship W1567242521A5008830473 @default.
• W1567242521 hasAuthorship W1567242521A5024942778 @default.
• W1567242521 hasAuthorship W1567242521A5048383270 @default.
• W1567242521 hasAuthorship W1567242521A5049742729 @default.
• W1567242521 hasAuthorship W1567242521A5049961089 @default.
• W1567242521 hasAuthorship W1567242521A5052530763 @default.
• W1567242521 hasAuthorship W1567242521A5078409600 @default.
• W1567242521 hasConcept C113214860 @default.
• W1567242521 hasConcept C126322002 @default.
• W1567242521 hasConcept C134018914 @default.
• W1567242521 hasConcept C139719470 @default.
• W1567242521 hasConcept C151956035 @default.
• W1567242521 hasConcept C162324750 @default.
• W1567242521 hasConcept C2776867660 @default.
• W1567242521 hasConcept C2777195454 @default.
• W1567242521 hasConcept C2779177272 @default.
• W1567242521 hasConcept C2779571634 @default.
• W1567242521 hasConcept C2781161787 @default.
• W1567242521 hasConcept C2993291352 @default.
• W1567242521 hasConcept C526584372 @default.
• W1567242521 hasConcept C71924100 @default.
• W1567242521 hasConceptScore W1567242521C113214860 @default.
• W1567242521 hasConceptScore W1567242521C126322002 @default.
• W1567242521 hasConceptScore W1567242521C134018914 @default.
• W1567242521 hasConceptScore W1567242521C139719470 @default.
• W1567242521 hasConceptScore W1567242521C151956035 @default.
• W1567242521 hasConceptScore W1567242521C162324750 @default.
• W1567242521 hasConceptScore W1567242521C2776867660 @default.
• W1567242521 hasConceptScore W1567242521C2777195454 @default.
• W1567242521 hasConceptScore W1567242521C2779177272 @default.
• W1567242521 hasConceptScore W1567242521C2779571634 @default.
• W1567242521 hasConceptScore W1567242521C2781161787 @default.
• W1567242521 hasConceptScore W1567242521C2993291352 @default.
• W1567242521 hasConceptScore W1567242521C526584372 @default.

• next