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• W1567246916 abstract "Diabetes and its microand macro-vascular complications constitute one of the principal social-health problems world-wide. It has high impact on the quality of life and prognosis of the individuals affected, as well as high direct and indirect economic costs to the Public Health Service. Following the publication of benchmark studies in the 1990s which indicated that the maintenance of glycaemia levels as close as possible to normality is associated with a lower incidence, progression and severity of the complications, the optimisation of metabolic control has been converted to a core therapeutic objective (DCCT, 1993; Herman, 1999; UKPDS, 1998). The tools for the management of diabetes have advanced spectacularly in these past few years, not only for the control of glycaemia but also for its measurement. As such, currently, there is a wide variety of drugs available with different mechanisms of action which, alone or in combination, enable a reasonable metabolic control in the majority of cases. Although insulin has been used for >80 years, the biggest advances in the mode of use have been over the last two decades. This change has been due, in great part, to: 1) development of new sources of insulin (analogues of insulin) together with the development and fine-tuning of different forms of its administration (continuous subcutaneous insulin infusion; CSII) in search of profiles of activity closer to the normal physiologic state; 2) change in philosophy in the therapeutic planning of diabetes, such that the strategies of coresponsibility and flexibility of life-style have become fundamental aspects; 3) introduction of self-control using capillary glycaemia (SCCG) in daily practice (De Witt & Hirsch, 2003); 4) recent incorporation in clinical practice of the use of glucose sensors, continuous glucose monitoring systems (CGMS) that generate the maximum information on modifications of glucose levels in plasma along the course of the whole day. This review centres on the importance, in clinical practice, of the metabolic control targets for patients with DM type 1. Difficulties in achieving glycaemia goals using multiple insulin injection with new insulin analogues, and modern technologies such as CGMS and CSII are extensively analysed." @default.
• W1567246916 created "2016-06-24" @default.
• W1567246916 creator A5009912196 @default.
• W1567246916 creator A5026559495 @default.
• W1567246916 creator A5059531373 @default.
• W1567246916 creator A5088211553 @default.
• W1567246916 date "2011-10-26" @default.
• W1567246916 modified "2023-09-30" @default.
• W1567246916 title "Metabolic Control Targets for Patients with Type 1 Diabetes in Clinical Practice" @default.
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