Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567247348> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1567247348 endingPage "14559" @default.
- W1567247348 startingPage "14554" @default.
- W1567247348 abstract "In this study, the molecular species distribution of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) synthesized by rabbit peritoneal and human peripheral neutrophils was examined. Radiolabeled platelet-activating factor synthesized from [3H]acetate by neutrophils stimulated with ionophore A23187, opsonized zymosan, or N-formyl-methionyl-leucyl-phenylalanine was separated into the individual molecular species on the basis of length and degree of unsaturation of the 1-O-alkyl chain using reverse-phase high-performance liquid chromatography. The predominant alkyl chains in the labeled platelet-activating factor synthesized by ionophore- or zymosan-stimulated rabbit cells were 15:0 (4%), 16:0 (43%), 18:0 (11%), and 18:1 (26%). This is in contrast to the alkyl chain distribution of the widely accepted precursor of platelet-activating factor, 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine, present in the cell. The major alkyl chains contained in the labeled platelet-activating factor synthesized by ionophore-, zymosan-, or N-formyl-methionyl-leucyl-phenylalanine-stimulated human neutrophils were 16:0 (40%), 17:0 (8 and 5%; two isomers), 18:0 (16%), and 18:1 (18%). As found with the rabbit cells, this distribution differs from the alkyl chain content of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine in human neutrophils, which contains less than 1% of each 17:0 isomer. We demonstrate here that the platelet-activating factor synthesized by rabbit peritoneal and human peripheral polymorphonuclear neutrophils is heterogeneous and that some selectivity exists in the choice of the 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine precursor for platelet-activating factor synthesis in these cells. It also appears that the molecular species distribution of platelet-activating factor is independent of the stimulus used to elicit its synthesis." @default.
- W1567247348 created "2016-06-24" @default.
- W1567247348 creator A5018504950 @default.
- W1567247348 creator A5038565281 @default.
- W1567247348 creator A5047262669 @default.
- W1567247348 date "1984-12-01" @default.
- W1567247348 modified "2023-10-02" @default.
- W1567247348 title "The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils." @default.
- W1567247348 cites W1489676968 @default.
- W1567247348 cites W1494180975 @default.
- W1567247348 cites W1539674135 @default.
- W1567247348 cites W1603870937 @default.
- W1567247348 cites W1942790970 @default.
- W1567247348 cites W1966129095 @default.
- W1567247348 cites W1974921893 @default.
- W1567247348 cites W1998627013 @default.
- W1567247348 cites W2001306586 @default.
- W1567247348 cites W2001682079 @default.
- W1567247348 cites W2004088054 @default.
- W1567247348 cites W2017347575 @default.
- W1567247348 cites W2026006417 @default.
- W1567247348 cites W2043353778 @default.
- W1567247348 cites W2065376637 @default.
- W1567247348 cites W2112760878 @default.
- W1567247348 cites W2151616214 @default.
- W1567247348 cites W2166376385 @default.
- W1567247348 cites W2225443389 @default.
- W1567247348 cites W2300552860 @default.
- W1567247348 cites W2337346338 @default.
- W1567247348 cites W2340093856 @default.
- W1567247348 cites W84007045 @default.
- W1567247348 doi "https://doi.org/10.1016/s0021-9258(17)42636-6" @default.
- W1567247348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6501307" @default.
- W1567247348 hasPublicationYear "1984" @default.
- W1567247348 type Work @default.
- W1567247348 sameAs 1567247348 @default.
- W1567247348 citedByCount "143" @default.
- W1567247348 countsByYear W15672473482012 @default.
- W1567247348 countsByYear W15672473482022 @default.
- W1567247348 crossrefType "journal-article" @default.
- W1567247348 hasAuthorship W1567247348A5018504950 @default.
- W1567247348 hasAuthorship W1567247348A5038565281 @default.
- W1567247348 hasAuthorship W1567247348A5047262669 @default.
- W1567247348 hasBestOaLocation W15672473481 @default.
- W1567247348 hasConcept C105795698 @default.
- W1567247348 hasConcept C110121322 @default.
- W1567247348 hasConcept C134306372 @default.
- W1567247348 hasConcept C153911025 @default.
- W1567247348 hasConcept C185592680 @default.
- W1567247348 hasConcept C203014093 @default.
- W1567247348 hasConcept C2779020240 @default.
- W1567247348 hasConcept C2779884254 @default.
- W1567247348 hasConcept C33923547 @default.
- W1567247348 hasConcept C55493867 @default.
- W1567247348 hasConcept C86803240 @default.
- W1567247348 hasConcept C89560881 @default.
- W1567247348 hasConcept C95444343 @default.
- W1567247348 hasConceptScore W1567247348C105795698 @default.
- W1567247348 hasConceptScore W1567247348C110121322 @default.
- W1567247348 hasConceptScore W1567247348C134306372 @default.
- W1567247348 hasConceptScore W1567247348C153911025 @default.
- W1567247348 hasConceptScore W1567247348C185592680 @default.
- W1567247348 hasConceptScore W1567247348C203014093 @default.
- W1567247348 hasConceptScore W1567247348C2779020240 @default.
- W1567247348 hasConceptScore W1567247348C2779884254 @default.
- W1567247348 hasConceptScore W1567247348C33923547 @default.
- W1567247348 hasConceptScore W1567247348C55493867 @default.
- W1567247348 hasConceptScore W1567247348C86803240 @default.
- W1567247348 hasConceptScore W1567247348C89560881 @default.
- W1567247348 hasConceptScore W1567247348C95444343 @default.
- W1567247348 hasIssue "23" @default.
- W1567247348 hasLocation W15672473481 @default.
- W1567247348 hasOpenAccess W1567247348 @default.
- W1567247348 hasPrimaryLocation W15672473481 @default.
- W1567247348 hasRelatedWork W1964068091 @default.
- W1567247348 hasRelatedWork W1990245377 @default.
- W1567247348 hasRelatedWork W1991708760 @default.
- W1567247348 hasRelatedWork W2039523611 @default.
- W1567247348 hasRelatedWork W2058306971 @default.
- W1567247348 hasRelatedWork W2069421750 @default.
- W1567247348 hasRelatedWork W2410266231 @default.
- W1567247348 hasRelatedWork W2467001622 @default.
- W1567247348 hasRelatedWork W3106129937 @default.
- W1567247348 hasRelatedWork W428088210 @default.
- W1567247348 hasVolume "259" @default.
- W1567247348 isParatext "false" @default.
- W1567247348 isRetracted "false" @default.
- W1567247348 magId "1567247348" @default.
- W1567247348 workType "article" @default.