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- W1567253059 endingPage "752" @default.
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- W1567253059 abstract "Chronic lymphocytic leukemia (CLL) remains the most incurable leukemia. Early chemotherapeutic treatments, including alkylating agents, purine nucleoside derivatives, and immunotherapeutic antibodies, only show limited benefits for patients but severe off-target related side effects. Recent advances in understanding of the critical molecular pathways of regulating proliferation and survival of B-CLL cells have spurred a new therapeutical strategy by selectively targeting phosphoinositide 3-kinase delta (PI3Kδ). Idelalisib, a first-in-class PI3Kδ-selective small molecule has received the FDA's fast-track approval in July of 2014 as a new treatment of CLL, indolent B-cell non-Hodgkin's lymphoma, and relapsed small lymphocytic lymphoma. Undoubtedly, the success of idelalisib has provided a solid support in the development of PI3Kδ-specific inhibitors and reformed the concept of treating CLL. However, the number of reported selective inhibitors of PI3Kδ is very limited and very few have advanced into clinical trials. The mechanism of their actions remains elusive. More profound understanding on the modes of action of new PI3Kδ inhibitors will further validate the PI3Kδ-targeting strategy, and help to identify biomarkers capable of stratifying patients who will most likely benefit from the therapy." @default.
- W1567253059 created "2016-06-24" @default.
- W1567253059 creator A5000061336 @default.
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- W1567253059 creator A5089348951 @default.
- W1567253059 date "2015-03-11" @default.
- W1567253059 modified "2023-09-26" @default.
- W1567253059 title "Targeting PI3Kδ: Emerging Therapy for Chronic Lymphocytic Leukemia and Beyond" @default.
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- W1567253059 doi "https://doi.org/10.1002/med.21341" @default.
- W1567253059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25763934" @default.
- W1567253059 hasPublicationYear "2015" @default.
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