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- W1567255336 abstract "Herein, we report the synthesis of novel tetrahydro‐β‐carbolines that induce cell death via the autophagic pathway. Five of the new compounds induced cell death in a panel of patient‐derived human metastatic melanoma cells. The autophagic pathway was confirmed using LC3 autophagosome markers; the involvement of ATG7 and Beclin 1 autophagy regulating genes was confirmed using infection with short hairpin RNA (shRNA) to silence Beclin 1 and ATG7. Compound VIII (IC 50 = 2.34–5.15 μM) displayed activities greater than cisplatin against a panel of patient‐derived human metastatic melanoma cell lines. The structure–activity relationship (SAR) of this class and the role of the absolute stereochemistry and geometrical isomerism are evaluated." @default.
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- W1567255336 date "2014-03-20" @default.
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- W1567255336 title "Discovery of a Novel Series of Tetrahydro-β-carbolines Inducing Autophagic Cell Death in Human Metastatic Melanoma" @default.
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- W1567255336 doi "https://doi.org/10.1002/ardp.201300437" @default.
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