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• W1567255686 abstract "The thiopurine drugs azathioprine (AZA) and 6-mercaptopurine (6-MP) are widely used in medicine, including inflammatory bowel diseases (IBD). Thiopurine drugs undergo S-methylation catalysed by thiopurine methyltransferase (TPMT) to methylmercaptopurine or oxidation to thiouric acid via xanthine oxidase (XO). Altered TPMT activity predominantly results from single nucleotide polymorphisms (SNPs) in the TPMT gene, which is located on chromosome 6p22.3.In the general population TPMT enzyme activity is normal in 89%, intermediate in approximately 11% and absent in approximately 0.3% of cases. The prevalence of the most frequent single nucleotide polymorphisms (SNPs) in the TPMT gene has been reported to vary worldwide. The mechanisms of AZA/6-MP action are currently unknown. Pharmacogenetics of AZA/6-MP represents an interesting field of research with direct implications in clinical practice. AZA/6- MP metabolization steps, the impact of TPMT gene SNPs on toxicity prediction as well as the 6p loci analysis represents a challenging field of research in IBD and other diseases. When possible, TPMT genotyping prior to the initiation of AZA/6-MP should be considered to decrease the risk of severe adverse event as well as to identify patients who might benefit from higher doses. Clinicians should be aware that TPMT SNPs do not explain all leucopenic events and that TPMT measurements cannot replace the need for continued monitoring of leucocyte counts in AZA/6-MP treated patients." @default.
• W1567255686 created "2016-06-24" @default.
• W1567255686 creator A5021827386 @default.
• W1567255686 creator A5082208636 @default.
• W1567255686 date "2008-03-24" @default.
• W1567255686 modified "2023-09-23" @default.
• W1567255686 title "Azathioprine/6-mercaptopurine toxicity: The role of the TPMT gene" @default.
• W1567255686 cites W1252407659 @default.
• W1567255686 cites W141364591 @default.
• W1567255686 cites W149083190 @default.
• W1567255686 cites W151343677 @default.
• W1567255686 cites W1533877602 @default.
• W1567255686 cites W1534517380 @default.
• W1567255686 cites W1573093552 @default.
• W1567255686 cites W1574225715 @default.
• W1567255686 cites W175110941 @default.
• W1567255686 cites W1963999321 @default.
• W1567255686 cites W1964947822 @default.
• W1567255686 cites W1965005464 @default.
• W1567255686 cites W1965382518 @default.
• W1567255686 cites W1966445767 @default.
• W1567255686 cites W1967490229 @default.
• W1567255686 cites W1969556302 @default.
• W1567255686 cites W1969768040 @default.
• W1567255686 cites W1972388266 @default.
• W1567255686 cites W1972773868 @default.
• W1567255686 cites W1973499262 @default.
• W1567255686 cites W1974878444 @default.
• W1567255686 cites W1976873312 @default.
• W1567255686 cites W1977548043 @default.
• W1567255686 cites W1977579337 @default.
• W1567255686 cites W1977912777 @default.
• W1567255686 cites W1978101829 @default.
• W1567255686 cites W1978270674 @default.
• W1567255686 cites W1978649965 @default.
• W1567255686 cites W1980098230 @default.
• W1567255686 cites W1980983505 @default.
• W1567255686 cites W1981330515 @default.
• W1567255686 cites W1982971906 @default.
• W1567255686 cites W1984641899 @default.
• W1567255686 cites W1984845647 @default.
• W1567255686 cites W1986278569 @default.
• W1567255686 cites W1987340563 @default.
• W1567255686 cites W1987560668 @default.
• W1567255686 cites W1991987579 @default.
• W1567255686 cites W1992078742 @default.
• W1567255686 cites W1992130450 @default.
• W1567255686 cites W1993436754 @default.
• W1567255686 cites W1996409190 @default.
• W1567255686 cites W1996549950 @default.
• W1567255686 cites W1996928332 @default.
• W1567255686 cites W1999416574 @default.
• W1567255686 cites W1999497064 @default.
• W1567255686 cites W2000842925 @default.
• W1567255686 cites W2001786662 @default.
• W1567255686 cites W2003111057 @default.
• W1567255686 cites W2004874110 @default.
• W1567255686 cites W2004962018 @default.
• W1567255686 cites W2006509677 @default.
• W1567255686 cites W2008981237 @default.
• W1567255686 cites W2009323679 @default.
• W1567255686 cites W2010037109 @default.
• W1567255686 cites W2010562848 @default.
• W1567255686 cites W2011687523 @default.
• W1567255686 cites W2011736072 @default.
• W1567255686 cites W2014191332 @default.
• W1567255686 cites W2014389034 @default.
• W1567255686 cites W2015076345 @default.
• W1567255686 cites W2015171301 @default.
• W1567255686 cites W2017060960 @default.
• W1567255686 cites W2022228924 @default.
• W1567255686 cites W2022704780 @default.
• W1567255686 cites W2027183498 @default.
• W1567255686 cites W2029841402 @default.
• W1567255686 cites W2030572354 @default.
• W1567255686 cites W2032534059 @default.
• W1567255686 cites W2033674020 @default.
• W1567255686 cites W2034809256 @default.
• W1567255686 cites W2035388060 @default.
• W1567255686 cites W2035762549 @default.
• W1567255686 cites W2036759750 @default.
• W1567255686 cites W2039148233 @default.
• W1567255686 cites W2040289932 @default.
• W1567255686 cites W2040498834 @default.
• W1567255686 cites W2041279680 @default.
• W1567255686 cites W2042975896 @default.
• W1567255686 cites W2043972735 @default.
• W1567255686 cites W2051544696 @default.
• W1567255686 cites W2053477714 @default.
• W1567255686 cites W2053948474 @default.
• W1567255686 cites W2054176565 @default.
• W1567255686 cites W2056237746 @default.
• W1567255686 cites W2056949557 @default.
• W1567255686 cites W2057492059 @default.
• W1567255686 cites W2060838383 @default.
• W1567255686 cites W2065876406 @default.
• W1567255686 cites W2067439491 @default.
• W1567255686 cites W2068481943 @default.

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