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- W1567256081 abstract "Early studies determined that proteolytic gluten peptides, not intact gluten protein, were the toxic constituents of wheat, rye and barley for celiac sprue patients. However, only recently have studies correlated gluten sequence to observed toxicity. The discovery of HLA-DQ2 as the primary disease-associated major histocompatibility complex protein, the isolation of DQ2-restricted (and infrequently DQ8- restricted) Th1 cells from mucosal biopsies of celiac patients, and the identification of transglutaminase-2 as the predominant celiac autoantigen led researchers to identify specific T-cell epitopes in gluten proteins. Correlation of proteolytic resistance of gluten peptides and immunotoxicity enabled the identification of oral glutenase supplementation as a possible therapeutic modality. The inability of gastric and pancreatic endoproteases to cleave after proline or glutamine residues and the inability of brush border membrane enzymes to digest long peptides initiated the hypothesis that exogenous proline- and/or glutamine-specific endoproteases would be effective glutenases. This hypothesis has subsequently gained support from in vitro, in vivo animal, and ex vivo human studies. Current and future directions for oral glutenase therapy of celiac sprue are discussed." @default.
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- W1567256081 date "2008-01-01" @default.
- W1567256081 modified "2023-09-23" @default.
- W1567256081 title "Oral Glutenase Therapy for Celiac Sprue" @default.
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- W1567256081 doi "https://doi.org/10.1159/000128996" @default.
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