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- W1567257368 abstract "2-Acetylaminofluorene, a potent hepatocarcinogen, bound to DNA when incubated with an isolated nuclei from rat liver. Nuclear monooxygenase was essential for this binding as shown by dependence on reduced nicotinamide adenine dinucleotide phosphate. The binding was increased by pretreatment of rats with 3-methylcholanthrene and was completely inhibited by the preincubation of nuclei with the antibody against reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase. Addition of microsomes to nuclei from untreated rats increased the binding of 2-acetylaminofluorene to DNA. Addition of microsomes from 3-methylcholanthrene-treated rats had about 5 times more effect on binding than had microsomes from untreated rats. The increase of this binding was inhibited by preincubation of microsomes with the antibody, indicating that microsome-activated 2-acetylaminofluorene entered into the nuclei. On the other hand, the addition of microsomes to the nuclei from 3-methylcholanthrene-treated rats decreased the binding of 2-acetylaminofluorene to DNA. The addition of the microsomes from untreated rats resulted in a greater decrease in binding than did microsomes from 3-methylcholanthrene-treated rats. These phenomena could be explained by the change in the influx and efflux of 2-acetylaminofluorene activated in nuclei and microsomes across nuclear membrane. The present study suggests that intracellular activation of 2-acetylaminofluorene occurs not only in the endoplasmic reticulum but also in the nuclear envelope." @default.
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- W1567257368 date "1979-03-01" @default.
- W1567257368 modified "2023-09-23" @default.
- W1567257368 title "Activation of 2-acetylaminofluorene in the nuclei of rat liver." @default.
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