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• W1567261937 startingPage "369" @default.
• W1567261937 abstract "Simian immunodeficiency virus (SIV)‐infection of nonhuman primates provides a relevant animal model system to study the pathogenesis of acquired immune deficiency syndrome (AIDS) and to evaluate experimental therapies and vaccine strategies This chapter discusses the virological, immunologic, and pathological characteristics of these animals. Rapid progressor (RP) macaques appear to result from an irreversible, massive, early virus‐induced killing of memory CD4 + T cells, resulting in a failure to maintain immune responses and the evolution of macrophagetropic and neutralization–sensitive variants. The pathogenesis appears to be restricted to direct cytopathic effects of SIV on the immune system as compared with the additional effects of immune activation–induced cell death and regenerative failure that accompanies slower disease progression. Additionally, unique envelope variants evolve in SIV‐mac and SIV‐sm ‐infected RP macaques. However, studies with molecular clones suggest that these variants are the end result of virus replication in a severely immunocompromised host rather than the direct cause of rapid progression." @default.
• W1567261937 created "2016-06-24" @default.
• W1567261937 creator A5054243164 @default.
• W1567261937 creator A5087217095 @default.
• W1567261937 date "2008-01-01" @default.
• W1567261937 modified "2023-09-26" @default.
• W1567261937 title "Rapid Disease Progression to AIDS due to Simian immunodeficiency virus Infection of Macaques: Host and Viral Factors" @default.
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