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• W1567282410 abstract "Two chloramphenicol resistance mutations were isolated in an Escherichia coli rRNA operon (rrnH) located on a multicopy plasmid. Both mutations also confer resistance to 14-atom lactone ring macrolide antibiotics, but they do not confer resistance to 16-atom lactone ring macrolide antibiotics or other inhibitors of the large ribosomal subunit. Classic genetic and recombinant DNA methods were used to map the two mutations to 154-base-pair regions of the 23S RNA genes. DNA sequencing of these regions revealed that chloramphenicol-erythromycin resistance results from a guanine-to-adenine transition at position 2057 of the 23S RNA genes of both independently isolated mutants. These mutations affect a region of 23S RNA strongly implicated in peptidyl transfer and known to interact with a variety of peptidyl transferase inhibitors." @default.
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• W1567282410 date "1985-05-01" @default.
• W1567282410 modified "2023-09-26" @default.
• W1567282410 title "Chloramphenicol-erythromycin resistance mutations in a 23S rRNA gene of Escherichia coli" @default.
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• W1567282410 doi "https://doi.org/10.1128/jb.162.2.551-557.1985" @default.
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