FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567298925> ?p ?o ?g. }

• W1567298925 endingPage "2167" @default.
• W1567298925 startingPage "2158" @default.
• W1567298925 abstract "Abstract We compared costimulatory signals provided by human endothelial cells (ECs) to those provided by conventional bone marrow-derived APCs, i.e., peripheral blood-adherent mononuclear cells (PBAMCs), by measuring their effects on cytokine production by naive or memory CD4+ T cells stimulated by PHA. In these assays, ECs effectively costimulate secretion of IL-2, IFN-γ, and IL-4 from both naive and memory CD4+ T cells, quantified by ELISA or intracellular cytokine staining. ECs, which lack B7 molecules, use predominantly leukocyte-function associated Ag 3 (LFA-3) to provide costimulation. ECs are comparable to or better than PBAMCs, which use both the LFA-3 and B7 molecules, at costimulating IL-2 and IL-4 production. ECs are less effective than PBAMCs at costimulating IFN-γ production by naive T cells. ECs do not secrete IL-12, and addition of exogenous IL-12 enables ECs to costimulate IFN-γ at a level comparable to that observed with PBAMCs. ECs do not promote differentiation of naive T cells to Th1-like cells, whereas PBAMCs do. Again, addition of exogenous IL-12 enables ECs to do so. Transfection of ECs to express B7-1 or B7-2 is less effective than IL-12 supplementation for restoring these responses. These experiments suggest that a deficiency in costimulation due to lack of B7 molecule expression does not fully explain the inability of ECs to activate resting naive CD4+ T cells." @default.
• W1567298925 created "2016-06-24" @default.
• W1567298925 creator A5022235365 @default.
• W1567298925 creator A5083443493 @default.
• W1567298925 date "1998-09-01" @default.
• W1567298925 modified "2023-10-16" @default.
• W1567298925 title "Human Endothelial Cells Effectively Costimulate Cytokine Production by, But Not Differentiation of, Naive CD4+ T Cells" @default.
• W1567298925 cites W1515766882 @default.
• W1567298925 cites W1527802692 @default.
• W1567298925 cites W1562057469 @default.
• W1567298925 cites W1563858750 @default.
• W1567298925 cites W1569511882 @default.
• W1567298925 cites W1574030303 @default.
• W1567298925 cites W1578996543 @default.
• W1567298925 cites W1596603699 @default.
• W1567298925 cites W1600694014 @default.
• W1567298925 cites W1634158134 @default.
• W1567298925 cites W1678453564 @default.
• W1567298925 cites W1827714052 @default.
• W1567298925 cites W1845629018 @default.
• W1567298925 cites W1861267112 @default.
• W1567298925 cites W1933255801 @default.
• W1567298925 cites W1942668068 @default.
• W1567298925 cites W1965923156 @default.
• W1567298925 cites W1969178843 @default.
• W1567298925 cites W1975058955 @default.
• W1567298925 cites W1977711837 @default.
• W1567298925 cites W1979514172 @default.
• W1567298925 cites W1986068499 @default.
• W1567298925 cites W1994948773 @default.
• W1567298925 cites W1997531619 @default.
• W1567298925 cites W2000517438 @default.
• W1567298925 cites W2000705732 @default.
• W1567298925 cites W2006178861 @default.
• W1567298925 cites W2019947165 @default.
• W1567298925 cites W2027581129 @default.
• W1567298925 cites W2037626742 @default.
• W1567298925 cites W2052895824 @default.
• W1567298925 cites W2063053561 @default.
• W1567298925 cites W2067049479 @default.
• W1567298925 cites W2072734854 @default.
• W1567298925 cites W2074011532 @default.
• W1567298925 cites W2080489850 @default.
• W1567298925 cites W2086776723 @default.
• W1567298925 cites W2091783976 @default.
• W1567298925 cites W2095904729 @default.
• W1567298925 cites W2119969523 @default.
• W1567298925 cites W2124116262 @default.
• W1567298925 cites W2127314810 @default.
• W1567298925 cites W2127800073 @default.
• W1567298925 cites W2134472621 @default.
• W1567298925 cites W2138239795 @default.
• W1567298925 cites W2150368859 @default.
• W1567298925 cites W2150763544 @default.
• W1567298925 cites W2150988478 @default.
• W1567298925 cites W2151192513 @default.
• W1567298925 cites W2153349227 @default.
• W1567298925 cites W2155782151 @default.
• W1567298925 cites W2161485037 @default.
• W1567298925 cites W2171831396 @default.
• W1567298925 cites W2172960056 @default.
• W1567298925 cites W2174557896 @default.
• W1567298925 doi "https://doi.org/10.4049/jimmunol.161.5.2158" @default.
• W1567298925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9725207" @default.
• W1567298925 hasPublicationYear "1998" @default.
• W1567298925 type Work @default.
• W1567298925 sameAs 1567298925 @default.
• W1567298925 citedByCount "100" @default.
• W1567298925 countsByYear W15672989252012 @default.
• W1567298925 countsByYear W15672989252013 @default.
• W1567298925 countsByYear W15672989252014 @default.
• W1567298925 countsByYear W15672989252015 @default.
• W1567298925 countsByYear W15672989252016 @default.
• W1567298925 countsByYear W15672989252017 @default.
• W1567298925 countsByYear W15672989252018 @default.
• W1567298925 countsByYear W15672989252019 @default.
• W1567298925 countsByYear W15672989252020 @default.
• W1567298925 countsByYear W15672989252021 @default.
• W1567298925 countsByYear W15672989252022 @default.
• W1567298925 countsByYear W15672989252023 @default.
• W1567298925 crossrefType "journal-article" @default.
• W1567298925 hasAuthorship W1567298925A5022235365 @default.
• W1567298925 hasAuthorship W1567298925A5083443493 @default.
• W1567298925 hasBestOaLocation W15672989251 @default.
• W1567298925 hasConcept C203014093 @default.
• W1567298925 hasConcept C2778690821 @default.
• W1567298925 hasConcept C49039625 @default.
• W1567298925 hasConcept C55493867 @default.
• W1567298925 hasConcept C86803240 @default.
• W1567298925 hasConcept C95444343 @default.
• W1567298925 hasConceptScore W1567298925C203014093 @default.
• W1567298925 hasConceptScore W1567298925C2778690821 @default.
• W1567298925 hasConceptScore W1567298925C49039625 @default.
• W1567298925 hasConceptScore W1567298925C55493867 @default.
• W1567298925 hasConceptScore W1567298925C86803240 @default.
• W1567298925 hasConceptScore W1567298925C95444343 @default.
• W1567298925 hasIssue "5" @default.
• W1567298925 hasLocation W15672989251 @default.

• next