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• W1567299306 abstract "The electrogenesis of synaptically activated dendritic Ca2+-mediated potentials, which may contribute to synaptic signal integration in pyramidal cells, was examined in rat layers V-VI prefrontal cortical (PFC) neurons in vitro. Intrasomatically recorded suprathreshold synaptic responses evoked by stimulation of the distal dendrites were attenuated by focal Cd2+ application to the proximal apical dendritic stem (100-200 micron from soma), but not to the apical dendritic tuft (>500 micron from soma). With use of intracellular QX-314 and Cs+ to block Na+ and K+ currents, intrasomatic recordings revealed that the Cd2+-induced attenuation of synaptic responses was attributable to the blockade of a dendritic Ca2+-mediated hump potential and high-threshold Ca2+ spike activated by NMDA EPSPs. The hump potential was not blocked by bath application of Ni2+ (100 microM) but was blocked by focal application of Cd2+ to the proximal but not distal apical dendrites, suggesting that it was generated by Ca2+ channels located in the proximal dendrites. Direct patch-clamp recordings made from the distal apical tuft of layers V-VI PFC neurons revealed that layers I-II synaptic stimulation or intradendritic depolarizing current pulses evoked tetrodotoxin- and QX-314-sensitive Na+ spikes. Unlike in the stem of the apical dendrite, Ca2+ spikes were not easily evoked in the distal apical tuft when Na+ channels were blocked. When triggered, the Cd2+-sensitive Ca2+ spikes in the dendritic tuft were nonregenerative and had very high activation thresholds (approximately +10 mV). These results suggested that the high voltage-activated Ca2+ potentials that amplify distal EPSPs are primarily generated in the proximal stem of the apical dendrite and not within the fine dendritic branches of the apical tuft of layers V-VI PFC neurons." @default.
• W1567299306 created "2016-06-24" @default.
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• W1567299306 date "1997-08-01" @default.
• W1567299306 modified "2023-10-10" @default.
• W1567299306 title "Contributions of Voltage-Gated Ca²⁺Channels in the Proximal versus Distal Dendrites to Synaptic Integration in Prefrontal Cortical Neurons" @default.
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• W1567299306 doi "https://doi.org/10.1523/jneurosci.17-15-05936.1997" @default.
• W1567299306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573188" @default.
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