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• W1567303410 startingPage "326" @default.
• W1567303410 abstract "ABSTRACT Treatment with γ‐aminobutiric acid (GABA B ) receptor agonist, ±baclofen, has been shown to reduce ethanol intake in selectively bred Sardinian alcohol‐preferring rats. The general goal of the present study was to characterize the high ethanol consumption high‐alcohol‐drinking University of Chile bibulous (UChB) rats with regard to the anti‐alcohol effect of GABA B receptor stimulation. UChB rats were treated with the more active enantiomer of baclofen [R(+)‐baclofen; at a dose of 1.0, 2.0 or 3.0 mg/kg] administered intraperitoneally once daily for four consecutive days or a single dose. When comparing ethanol and saccharin consumption in a free‐choice regimen with unlimited access 24 hours/day, the dose of baclofen required to attenuate ethanol consumption significantly was 1.0 mg/kg administered once a day for three consecutive days while the dose that was sufficient to affect saccharin consumption significantly was 2.0 mg/kg, indicating that baclofen was more potent in reducing ethanol intake by UChB rats than reducing saccharin consumption. The reduction of ethanol or saccharin intake can not be attributed to baclofen‐induced motor impairment, since baclofen (1.0, 2.0 or 3.0 mg/kg) did not alter spontaneous locomotor activity in UChB rats. Baclofen dose‐dependently suppressed the motor activity stimulated by ethanol administration, a phenomenon mediated by activation of the mesolimbic dopamine system. In conclusion, these results showed that the activation of GABA B receptor by R(+)‐baclofen reduced ethanol and saccharin consumption, as well as ethanol‐induced motor stimulation, implicating the GABA B receptor in the neural substrates mediating effects that sustain voluntary ethanol in take in UChB rats." @default.
• W1567303410 created "2016-06-24" @default.
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• W1567303410 date "2008-08-07" @default.
• W1567303410 modified "2023-10-04" @default.
• W1567303410 title "PRECLINICAL STUDY: Baclofen reduces ethanol intake in high‐alcohol‐drinking University of Chile bibulous rats" @default.
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• W1567303410 doi "https://doi.org/10.1111/j.1369-1600.2008.00102.x" @default.
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