Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567305055> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1567305055 endingPage "248" @default.
- W1567305055 startingPage "241" @default.
- W1567305055 abstract "Heme oxygenase-1 (HO-1) is an enzyme that is highly inducible by various cellular stressors, especially oxidant injury. Our laboratory and others have demonstrated that induction of HO-1 exerts an antiinflammatory effect both in vitro and in vivo. We hypothesized that carbon monoxide (CO), a major catalytic byproduct of heme catalysis by HO-1, may mediate this antiinflammatory effect by modulating signal transduction pathways, in particular the mitogen-activated protein (MAP) kinase pathway. Confluent primary cultures of rat pulmonary artery endothelial cells (RPAEC) were treated with tumor necrosis factor-alpha (TNF-alpha; 50 ng/ml), and whole-cell extracts were assayed for phosphorylated ERK1/2, JNK1/2, and p38 MAP kinases. These three major MAP kinase pathways were activated by TNF-alpha in a time-dependent manner. RPAEC treated with TNF-alpha in the presence of a low concentration of CO (1%) exhibited marked attenuation of the phosphorylation of ERK1/2 MAP kinase when compared with cells treated with TNF-alpha alone. A similar effect was seen on the upstream MEK 1/2 kinase. Interestingly, CO (1%) accentuated TNF-alpha-induced phosphorylated p38 MAP kinase. These effects of exogenous CO on the ERK1/2 and p38 systems could be replicated by overexpression of HO-1 in RPAEC, using an adenoviral vector. As these MAP kinases are implicated in the regulation of various inflammatory molecules and adhesion molecules, our data provide a potential mechanism by which HO-1, acting via CO, may modulate the inflammatory response by differential activation of the MAP kinase pathway." @default.
- W1567305055 created "2016-06-24" @default.
- W1567305055 creator A5026924053 @default.
- W1567305055 creator A5028298831 @default.
- W1567305055 creator A5083500925 @default.
- W1567305055 date "2002-04-01" @default.
- W1567305055 modified "2023-09-24" @default.
- W1567305055 title "Differential Modulation by Exogenous Carbon Monoxide of TNF-α Stimulated Mitogen-Activated Protein Kinases in Rat Pulmonary Artery Endothelial Cells" @default.
- W1567305055 cites W1600690434 @default.
- W1567305055 cites W1966582616 @default.
- W1567305055 cites W2001019228 @default.
- W1567305055 cites W2028778467 @default.
- W1567305055 cites W2031923131 @default.
- W1567305055 cites W2087450601 @default.
- W1567305055 cites W2089484142 @default.
- W1567305055 cites W2115485369 @default.
- W1567305055 cites W2120505405 @default.
- W1567305055 cites W2122057254 @default.
- W1567305055 cites W2124595022 @default.
- W1567305055 cites W2145287139 @default.
- W1567305055 cites W4249247822 @default.
- W1567305055 doi "https://doi.org/10.1089/152308602753666299" @default.
- W1567305055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12006175" @default.
- W1567305055 hasPublicationYear "2002" @default.
- W1567305055 type Work @default.
- W1567305055 sameAs 1567305055 @default.
- W1567305055 citedByCount "28" @default.
- W1567305055 countsByYear W15673050552012 @default.
- W1567305055 countsByYear W15673050552015 @default.
- W1567305055 countsByYear W15673050552016 @default.
- W1567305055 countsByYear W15673050552017 @default.
- W1567305055 countsByYear W15673050552019 @default.
- W1567305055 countsByYear W15673050552021 @default.
- W1567305055 crossrefType "journal-article" @default.
- W1567305055 hasAuthorship W1567305055A5026924053 @default.
- W1567305055 hasAuthorship W1567305055A5028298831 @default.
- W1567305055 hasAuthorship W1567305055A5083500925 @default.
- W1567305055 hasConcept C11960822 @default.
- W1567305055 hasConcept C132149769 @default.
- W1567305055 hasConcept C134018914 @default.
- W1567305055 hasConcept C137361374 @default.
- W1567305055 hasConcept C153911025 @default.
- W1567305055 hasConcept C163035849 @default.
- W1567305055 hasConcept C17991360 @default.
- W1567305055 hasConcept C181199279 @default.
- W1567305055 hasConcept C184235292 @default.
- W1567305055 hasConcept C185592680 @default.
- W1567305055 hasConcept C2776217839 @default.
- W1567305055 hasConcept C2779219270 @default.
- W1567305055 hasConcept C51551487 @default.
- W1567305055 hasConcept C55493867 @default.
- W1567305055 hasConcept C62478195 @default.
- W1567305055 hasConcept C86803240 @default.
- W1567305055 hasConcept C95444343 @default.
- W1567305055 hasConcept C97029542 @default.
- W1567305055 hasConceptScore W1567305055C11960822 @default.
- W1567305055 hasConceptScore W1567305055C132149769 @default.
- W1567305055 hasConceptScore W1567305055C134018914 @default.
- W1567305055 hasConceptScore W1567305055C137361374 @default.
- W1567305055 hasConceptScore W1567305055C153911025 @default.
- W1567305055 hasConceptScore W1567305055C163035849 @default.
- W1567305055 hasConceptScore W1567305055C17991360 @default.
- W1567305055 hasConceptScore W1567305055C181199279 @default.
- W1567305055 hasConceptScore W1567305055C184235292 @default.
- W1567305055 hasConceptScore W1567305055C185592680 @default.
- W1567305055 hasConceptScore W1567305055C2776217839 @default.
- W1567305055 hasConceptScore W1567305055C2779219270 @default.
- W1567305055 hasConceptScore W1567305055C51551487 @default.
- W1567305055 hasConceptScore W1567305055C55493867 @default.
- W1567305055 hasConceptScore W1567305055C62478195 @default.
- W1567305055 hasConceptScore W1567305055C86803240 @default.
- W1567305055 hasConceptScore W1567305055C95444343 @default.
- W1567305055 hasConceptScore W1567305055C97029542 @default.
- W1567305055 hasIssue "2" @default.
- W1567305055 hasLocation W15673050551 @default.
- W1567305055 hasLocation W15673050552 @default.
- W1567305055 hasOpenAccess W1567305055 @default.
- W1567305055 hasPrimaryLocation W15673050551 @default.
- W1567305055 hasRelatedWork W1501075116 @default.
- W1567305055 hasRelatedWork W1567305055 @default.
- W1567305055 hasRelatedWork W2027159465 @default.
- W1567305055 hasRelatedWork W2083601932 @default.
- W1567305055 hasRelatedWork W2085362455 @default.
- W1567305055 hasRelatedWork W2093470392 @default.
- W1567305055 hasRelatedWork W2095255069 @default.
- W1567305055 hasRelatedWork W2134030137 @default.
- W1567305055 hasRelatedWork W2463369257 @default.
- W1567305055 hasRelatedWork W3124600148 @default.
- W1567305055 hasVolume "4" @default.
- W1567305055 isParatext "false" @default.
- W1567305055 isRetracted "false" @default.
- W1567305055 magId "1567305055" @default.
- W1567305055 workType "article" @default.