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• W1567315119 abstract "Methylphosphonate (PC) backbone oligodeoxynucleotides complementary to the 5'-terminal nucleotides of U1 and U2 small nuclear (sn) RNAs do not elicit RNase H action under conditions in which natural (phosphodiester) oligodeoxynucleotides yield extensive RNase H cleavage. We show here that antisense PC oligonucleotides can mask sites in U1 and U2 snRNPs that are required for spliceosome formation. We further report that biotinylated derivatives of antisense PC oligos can be used for affinity selection of U1 and U2 snRNPs." @default.
• W1567315119 created "2016-06-24" @default.
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• W1567315119 date "1991-01-01" @default.
• W1567315119 modified "2023-09-30" @default.
• W1567315119 title "Biotinylated antisense methylphosphonate oligodeoxynucleotides. Inhibition of spliceosome assembly and affinity selection of U1 and U2 small nuclear RNPs." @default.
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• W1567315119 doi "https://doi.org/10.1016/s0021-9258(18)52458-3" @default.
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