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- W1567320710 abstract "Summary The Plasmodium falciparum genome sequence has boosted hopes for a new era of malaria research and for the application of comprehensive molecular knowledge to disease control, but formidable obstacles remain: ≈ 60% of the predicted P. falciparum proteins have no known functions or homologues, and most life cycle stages of this haploid eukaryotic parasite are relatively intractable to cultivation and biochemical manipulation. Genetic mapping based on high‐resolution maps saturated with single‐nucleotide polymorphisms or microsatellites is now providing effective strategies for discovering candidate genes determining important parasite phenotypes. Here we review classical linkage studies using laboratory crosses and population associations that are now amenable to genome‐wide approaches and are revealing multiple candidate genes involved in complex drug responses. Moreover, mapping by linkage disequilibrium is practicable in cases where chromosomal segments flanking drug‐selected genes have been preserved in populations during relatively recent P. falciparum evolution. We discuss the advantages and limitations of these various genetic mapping strategies, results from which offer complementary insights to those emerging from gene knockout experiments and/or high‐throughput genomic technologies." @default.
- W1567320710 created "2016-06-24" @default.
- W1567320710 creator A5007600048 @default.
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- W1567320710 date "2004-08-12" @default.
- W1567320710 modified "2023-10-15" @default.
- W1567320710 title "Genetic mapping in the human malaria parasite Plasmodium falciparum" @default.
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- W1567320710 doi "https://doi.org/10.1111/j.1365-2958.2004.04270.x" @default.
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