Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567324010> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1567324010 endingPage "106" @default.
- W1567324010 startingPage "97" @default.
- W1567324010 abstract "Pyruvate carboxylase activity in human liver has been examined with a modification of the method of Utter and Keech. The enzyme is located in mitochondria. Activity in homogenates at a final dilution of 1:100 is directly proportional to time of incubation and amount of tissue incubated. Concentration-dependent kinetics with pyruvate between 0.1 mm, and in the presence of 0.7 mm acetyl-CoA reveal a low-Km component (Km, 0.3 mm) and a high-Km component (2.4 mm). When the observed total activity is resolved into two discrete components the corrected Km values are 0.4 and 3.7 mm, respectively. A patient with intermittent lactic acidosis, associated with hypoglycemia and hyperpyruvicacidemia (1 mm versus normal value, 0.1 mm) has deficient pyruvate carboxylase activity, with a missing low-Km component. These findings indicate considerable complexity in the catalytic function for pyruvate carboxylation in human liver." @default.
- W1567324010 created "2016-06-24" @default.
- W1567324010 creator A5030487571 @default.
- W1567324010 creator A5032783125 @default.
- W1567324010 creator A5078702171 @default.
- W1567324010 date "1974-06-01" @default.
- W1567324010 modified "2023-10-18" @default.
- W1567324010 title "Pyruvate carboxylase in human liver" @default.
- W1567324010 cites W1205458192 @default.
- W1567324010 cites W1524783585 @default.
- W1567324010 cites W1538721208 @default.
- W1567324010 cites W1541224027 @default.
- W1567324010 cites W1552834886 @default.
- W1567324010 cites W1582996069 @default.
- W1567324010 cites W1988151960 @default.
- W1567324010 cites W2000725933 @default.
- W1567324010 cites W2027912455 @default.
- W1567324010 cites W2032157645 @default.
- W1567324010 cites W203321040 @default.
- W1567324010 cites W2052967277 @default.
- W1567324010 cites W2101987940 @default.
- W1567324010 cites W2148214014 @default.
- W1567324010 cites W2153435210 @default.
- W1567324010 cites W2400146673 @default.
- W1567324010 cites W2415205045 @default.
- W1567324010 cites W540731 @default.
- W1567324010 doi "https://doi.org/10.1016/0006-2944(74)90012-x" @default.
- W1567324010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4364467" @default.
- W1567324010 hasPublicationYear "1974" @default.
- W1567324010 type Work @default.
- W1567324010 sameAs 1567324010 @default.
- W1567324010 citedByCount "8" @default.
- W1567324010 crossrefType "journal-article" @default.
- W1567324010 hasAuthorship W1567324010A5030487571 @default.
- W1567324010 hasAuthorship W1567324010A5032783125 @default.
- W1567324010 hasAuthorship W1567324010A5078702171 @default.
- W1567324010 hasConcept C101972281 @default.
- W1567324010 hasConcept C121332964 @default.
- W1567324010 hasConcept C140137476 @default.
- W1567324010 hasConcept C148898269 @default.
- W1567324010 hasConcept C161790260 @default.
- W1567324010 hasConcept C181199279 @default.
- W1567324010 hasConcept C185592680 @default.
- W1567324010 hasConcept C20904676 @default.
- W1567324010 hasConcept C24428623 @default.
- W1567324010 hasConcept C25642318 @default.
- W1567324010 hasConcept C2780317664 @default.
- W1567324010 hasConcept C55493867 @default.
- W1567324010 hasConcept C62520636 @default.
- W1567324010 hasConceptScore W1567324010C101972281 @default.
- W1567324010 hasConceptScore W1567324010C121332964 @default.
- W1567324010 hasConceptScore W1567324010C140137476 @default.
- W1567324010 hasConceptScore W1567324010C148898269 @default.
- W1567324010 hasConceptScore W1567324010C161790260 @default.
- W1567324010 hasConceptScore W1567324010C181199279 @default.
- W1567324010 hasConceptScore W1567324010C185592680 @default.
- W1567324010 hasConceptScore W1567324010C20904676 @default.
- W1567324010 hasConceptScore W1567324010C24428623 @default.
- W1567324010 hasConceptScore W1567324010C25642318 @default.
- W1567324010 hasConceptScore W1567324010C2780317664 @default.
- W1567324010 hasConceptScore W1567324010C55493867 @default.
- W1567324010 hasConceptScore W1567324010C62520636 @default.
- W1567324010 hasIssue "2" @default.
- W1567324010 hasLocation W15673240101 @default.
- W1567324010 hasLocation W15673240102 @default.
- W1567324010 hasOpenAccess W1567324010 @default.
- W1567324010 hasPrimaryLocation W15673240101 @default.
- W1567324010 hasRelatedWork W1567324010 @default.
- W1567324010 hasRelatedWork W1590547955 @default.
- W1567324010 hasRelatedWork W1966518030 @default.
- W1567324010 hasRelatedWork W2065801355 @default.
- W1567324010 hasRelatedWork W2066354901 @default.
- W1567324010 hasRelatedWork W2068877048 @default.
- W1567324010 hasRelatedWork W2110573736 @default.
- W1567324010 hasRelatedWork W2135998024 @default.
- W1567324010 hasRelatedWork W2144477977 @default.
- W1567324010 hasRelatedWork W2171787368 @default.
- W1567324010 hasVolume "10" @default.
- W1567324010 isParatext "false" @default.
- W1567324010 isRetracted "false" @default.
- W1567324010 magId "1567324010" @default.
- W1567324010 workType "article" @default.