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- W156732404 abstract "The reproductive process is an inefficient one, and there is a considerable amount of fetal wastage in a variety of species. This phenomenon had been best studied in the human, rat, and mouse: 48% to 74% of human conceptuses are lost (4); in rats bearing the major histocompatibility complex (MHC)-linked grc genes, 20% to 25% of grc homozygotes die in the immediate postnatal period (15); and in the CBA x DBA/2 mating combination in mice, approximately 30% of the conceptuses abort spontaneously (1,13). We have tried to organize the various immunological and genetic factors that influence reproduction into an integrated hypothesis that focuses primarily on the effects of MHC and MHC-linked genes (5,6). This hypothesis is outlined in Figure 15.1. The most important factor in the control of normal fetal development is genetic compatibility between the mating partners. Once this critical condition has been met, a variety of immunological factors may modulate the implantation process under certain conditions. Genetic compatibility requires that the mating partners contribute no recessive lethal genes that could act alone or epistatically in the developing fetus. The immunological response in normal pregnancies is not destructive, because it is not directed against the classical class I transplantation antigens but rather against a unique placental class I antigen(s) that has broadly shared (public) specificities only and not hapiotype-specific (private) specificities. In the cases where immunological modulation has been shown to affect implantation, the mechanisms are not yet known." @default.
- W156732404 created "2016-06-24" @default.
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- W156732404 date "1988-01-01" @default.
- W156732404 modified "2023-09-22" @default.
- W156732404 title "Immunogenetic Control of Pregnancy and Development" @default.
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- W156732404 doi "https://doi.org/10.1007/978-1-4612-3746-4_15" @default.
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