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• W1567346019 abstract "The 3'-poly(A) tail, found on virtually all mRNAs, is enzymatically shortened by a process referred to as deadenylation. Deadenylation is a widespread means of controlling mRNA stability and translation. The enzymes involved-so-called deadenylases-are surprisingly diverse. They are controlled by RNA sequences commonly found in 3'-untranslated regions (UTRs), which bind regulatory factors. Both RNA-binding proteins and microRNAs accelerate deadenylation of specific mRNAs. In some cases, regulators enhance deadenylation by binding to and recruiting specific deadenylases to the target mRNA. The many hundreds of potential regulators encoded in mammalian genomes (both RNA-binding proteins and microRNAs) and the numerous deadenylases, coupled with the many potential regulatory sites represented in 3' UTRs of mRNAs, provide fertile ground for regulated deadenylation. Recent global studies of poly(A) regulation support this conclusion. Biochemical and genetic approaches will be essential for exploring regulated deadenylation. The methods we describe focus on the reconstruction in vitro of regulated deadenylation with purified components from yeast. We discuss broadly the strategies, problems, and history of in vitro deadenylation systems. We combine this with a more detailed discussion of the purification, activity, and regulation of the Saccharomyces cerevisiae Ccr4p-Pop2p deadenylase complex and its regulation by PUF (Pumilio and Fem-3 binding factor) RNA-binding proteins." @default.
• W1567346019 created "2016-06-24" @default.
• W1567346019 creator A5000082412 @default.
• W1567346019 creator A5019580706 @default.
• W1567346019 creator A5086437576 @default.
• W1567346019 date "2008-01-01" @default.
• W1567346019 modified "2023-10-16" @default.
• W1567346019 title "Chapter 5 Regulated Deadenylation In Vitro" @default.
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• W1567346019 doi "https://doi.org/10.1016/s0076-6879(08)02605-0" @default.
• W1567346019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19111172" @default.
• W1567346019 hasPublicationYear "2008" @default.
• W1567346019 type Work @default.
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