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- W1567346447 abstract "Abstract Skin, the largest organ of human body, is under frequent assaults by various environmental agents. To maintain its integrity and function, immune cells in the skin are tightly regulated to allow tolerance to harmless antigens but mount effective response to dangerous assaults, and their dysregulation might increase incidence of skin diseases. CCR10, with its ligand CCL27 uniquely expressed by keratinocytes, are the most skin-specific chemokine/receptor pair implicated in the skin T cell migration and inflammatory diseases. However, targeting CCR10 or CCL27 had little effects on these processes in animal models and the regulation and function of CCR10 in vivo remain elusive. Using CCR10 knockout/EGFP knockin mice we found that CCR10-/- mice had imbalanced numbers and dysregulated functions of skin-resident effector and regulatory T (Teff and Treg) cells associated with enhanced innate and memory skin immune responses to antigen stimulations. On the other hand, CCR10 -/- mice cleared the skin Leishmania major (L. major) infection more efficiently than wild type (WT) mice did. Adoptive transfer studies found that CCR10 is required for the migration and maintenance of skin-resident CD8+ and CD4+ cells into homeostatic skin but not during the inflammation. These findings reveal that the CCR10/CCL27 axis plays important roles in the migration, maintenance and function of skin-resident regulatory and effector T cells for the local homeostatic regulation." @default.
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- W1567346447 date "2014-05-01" @default.
- W1567346447 modified "2023-09-27" @default.
- W1567346447 title "CCR10 regulates maintenance and function of resident regulatory and effector T cells in the skin (MUC7P.772)" @default.
- W1567346447 doi "https://doi.org/10.4049/jimmunol.192.supp.197.24" @default.
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