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- W1567364235 abstract "The kynurenine metabolic pathway from tryptophan accounts for a large proportion of the metabolism of this amino acid in the brain. Although a major route for the generation of the essential co-factor nicotinamide adenine dinucleotide (NAD), two components of the pathway have marked effects on neurons. Quinolinic acid is an agonist at N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors, while kynurenic acid is an antagonist and, thus, a potential neuroprotectant. The levels of quinolinic acid are known to increase substantially following cerebral insults or infection, and has been most clearly implicated in the AIDS-dementia complex. The actions of quinolinic acid and NMDA show subtle differences, however, which suggest other factors contributing to cell damage. In this article we review the evidence that free radicals may be involved in the neurotoxic effects of quinolinic acid and consider the possibility that quinolinic acid might be involved in Alzheimer's disease. Finally, adenosine receptor ligands can modulate neuronal damage, supporting the view that they may represent suitable targets for the development of novel neuroprotectant drugs for the treatment of Alzheimer's and other neurodegenerative disorders." @default.
- W1567364235 created "2016-06-24" @default.
- W1567364235 creator A5059751466 @default.
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- W1567364235 creator A5073015039 @default.
- W1567364235 creator A5077969515 @default.
- W1567364235 creator A5091818593 @default.
- W1567364235 date "2001-08-07" @default.
- W1567364235 modified "2023-09-27" @default.
- W1567364235 title "The role of kynurenines in the production of neuronal death, and the neuroprotective effect of purines" @default.
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