Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567369816> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1567369816 endingPage "1182" @default.
- W1567369816 startingPage "1176" @default.
- W1567369816 abstract "Summary The present paper reports studies of a third kindred which manifests the hereditary C2 deficiency trait. The homozygous individual had no detectable hemolytic serum complement or C2 activity, although C2 could be detected by immune adherence; three heterozygous members of the family had 60 to 70% of the normal serum C2 titers. Normal or elevated serum C1, C3, C4 and C5 levels were obtained in all members of the kindred. There was no evidence for a C2 inhibitor in the propositus' serum; in addition, the deficiency could be corrected by the addition of purified C2. An analytical technique which permits quantitation of very small amounts of C2 was developed and applied to the measurement of C2 in the serum of members of the family. It is based upon the quantitation of C3 uptake by EAC1, 4 as a function of C2 concentration, i.e., the immediate reaction product of a C2-dependent reaction is measured. The serum C2 level was found to be 0.5 to 4% of normal in the homozygous individual and 60 to 70% of normal in the heterozygotes. When normal sera were assayed by this technique, the C2 titers obtained were in good agreement with the values obtained by hemolytic titrations." @default.
- W1567369816 created "2016-06-24" @default.
- W1567369816 creator A5040738782 @default.
- W1567369816 creator A5042418157 @default.
- W1567369816 creator A5061054341 @default.
- W1567369816 date "1968-12-01" @default.
- W1567369816 modified "2023-10-10" @default.
- W1567369816 title "Studies of an Additional Kindred with Hereditary Deficiency of the Second Component of Human Complement (C2) and Description of a New Method for the Quantitation of C2" @default.
- W1567369816 doi "https://doi.org/10.4049/jimmunol.101.6.1176" @default.
- W1567369816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5749189" @default.
- W1567369816 hasPublicationYear "1968" @default.
- W1567369816 type Work @default.
- W1567369816 sameAs 1567369816 @default.
- W1567369816 citedByCount "41" @default.
- W1567369816 crossrefType "journal-article" @default.
- W1567369816 hasAuthorship W1567369816A5040738782 @default.
- W1567369816 hasAuthorship W1567369816A5042418157 @default.
- W1567369816 hasAuthorship W1567369816A5061054341 @default.
- W1567369816 hasBestOaLocation W15673698161 @default.
- W1567369816 hasConcept C104317684 @default.
- W1567369816 hasConcept C112313634 @default.
- W1567369816 hasConcept C127716648 @default.
- W1567369816 hasConcept C14036430 @default.
- W1567369816 hasConcept C153471976 @default.
- W1567369816 hasConcept C159654299 @default.
- W1567369816 hasConcept C180754005 @default.
- W1567369816 hasConcept C185592680 @default.
- W1567369816 hasConcept C188082640 @default.
- W1567369816 hasConcept C203014093 @default.
- W1567369816 hasConcept C32611913 @default.
- W1567369816 hasConcept C54355233 @default.
- W1567369816 hasConcept C55493867 @default.
- W1567369816 hasConcept C71924100 @default.
- W1567369816 hasConcept C86803240 @default.
- W1567369816 hasConceptScore W1567369816C104317684 @default.
- W1567369816 hasConceptScore W1567369816C112313634 @default.
- W1567369816 hasConceptScore W1567369816C127716648 @default.
- W1567369816 hasConceptScore W1567369816C14036430 @default.
- W1567369816 hasConceptScore W1567369816C153471976 @default.
- W1567369816 hasConceptScore W1567369816C159654299 @default.
- W1567369816 hasConceptScore W1567369816C180754005 @default.
- W1567369816 hasConceptScore W1567369816C185592680 @default.
- W1567369816 hasConceptScore W1567369816C188082640 @default.
- W1567369816 hasConceptScore W1567369816C203014093 @default.
- W1567369816 hasConceptScore W1567369816C32611913 @default.
- W1567369816 hasConceptScore W1567369816C54355233 @default.
- W1567369816 hasConceptScore W1567369816C55493867 @default.
- W1567369816 hasConceptScore W1567369816C71924100 @default.
- W1567369816 hasConceptScore W1567369816C86803240 @default.
- W1567369816 hasIssue "6" @default.
- W1567369816 hasLocation W15673698161 @default.
- W1567369816 hasLocation W15673698162 @default.
- W1567369816 hasOpenAccess W1567369816 @default.
- W1567369816 hasPrimaryLocation W15673698161 @default.
- W1567369816 hasRelatedWork W2047819786 @default.
- W1567369816 hasRelatedWork W2349321798 @default.
- W1567369816 hasRelatedWork W2356552713 @default.
- W1567369816 hasRelatedWork W2363132949 @default.
- W1567369816 hasRelatedWork W2369595263 @default.
- W1567369816 hasRelatedWork W2379690395 @default.
- W1567369816 hasRelatedWork W2382566571 @default.
- W1567369816 hasRelatedWork W2390432525 @default.
- W1567369816 hasRelatedWork W2603093586 @default.
- W1567369816 hasRelatedWork W4214624536 @default.
- W1567369816 hasVolume "101" @default.
- W1567369816 isParatext "false" @default.
- W1567369816 isRetracted "false" @default.
- W1567369816 magId "1567369816" @default.
- W1567369816 workType "article" @default.