Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567376298> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W1567376298 endingPage "288" @default.
- W1567376298 startingPage "287" @default.
- W1567376298 abstract "The RAS family of small GTPases play critical roles in many types of human cancer. Activating RAS mutations are the most frequent type of oncogene mutations in human cancers, and are especially common in pancreatic, lung, and colorectal cancer. However, failure to obtain clinically useful inhibitors for RAS or any other GTPases suggests this target family is a therapeutic challenge. Consequently, significant efforts have been shifted toward targeting of downstream effectors of RAS including the Raf-MEK-ERK kinase pathway and the PI3K-AKT-mTOR kinase pathway. A third arm of RAS effector signaling, RAL (Ras-like) has not been targeted until recently and like RAS, is activated, but unlike RAS is not commonly mutated in cancer. RAL also shares a high structure similarity with RAS and other GTPase of the RAS superfamily. The two isoforms RALA and RALB are both important drivers of the proliferation, survival and metastasis of multiple human cancers. In our recent publication we reported the discovery of small molecule inhibitors of RAL.1" @default.
- W1567376298 created "2016-06-24" @default.
- W1567376298 creator A5020183452 @default.
- W1567376298 creator A5022572701 @default.
- W1567376298 date "2015-02-01" @default.
- W1567376298 modified "2023-10-18" @default.
- W1567376298 title "One step closer to targeting RAS" @default.
- W1567376298 cites W1971102429 @default.
- W1567376298 cites W2012479646 @default.
- W1567376298 cites W2050972073 @default.
- W1567376298 cites W2076865122 @default.
- W1567376298 cites W2146926552 @default.
- W1567376298 doi "https://doi.org/10.1080/15384101.2015.1006534" @default.
- W1567376298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4614980" @default.
- W1567376298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25591050" @default.
- W1567376298 hasPublicationYear "2015" @default.
- W1567376298 type Work @default.
- W1567376298 sameAs 1567376298 @default.
- W1567376298 citedByCount "1" @default.
- W1567376298 countsByYear W15673762982018 @default.
- W1567376298 crossrefType "journal-article" @default.
- W1567376298 hasAuthorship W1567376298A5020183452 @default.
- W1567376298 hasAuthorship W1567376298A5022572701 @default.
- W1567376298 hasBestOaLocation W15673762981 @default.
- W1567376298 hasConcept C502942594 @default.
- W1567376298 hasConcept C70721500 @default.
- W1567376298 hasConcept C86803240 @default.
- W1567376298 hasConcept C95444343 @default.
- W1567376298 hasConceptScore W1567376298C502942594 @default.
- W1567376298 hasConceptScore W1567376298C70721500 @default.
- W1567376298 hasConceptScore W1567376298C86803240 @default.
- W1567376298 hasConceptScore W1567376298C95444343 @default.
- W1567376298 hasIssue "3" @default.
- W1567376298 hasLocation W15673762981 @default.
- W1567376298 hasLocation W15673762982 @default.
- W1567376298 hasLocation W15673762983 @default.
- W1567376298 hasLocation W15673762984 @default.
- W1567376298 hasOpenAccess W1567376298 @default.
- W1567376298 hasPrimaryLocation W15673762981 @default.
- W1567376298 hasRelatedWork W1641042124 @default.
- W1567376298 hasRelatedWork W1990804418 @default.
- W1567376298 hasRelatedWork W1993764875 @default.
- W1567376298 hasRelatedWork W2013243191 @default.
- W1567376298 hasRelatedWork W2046158694 @default.
- W1567376298 hasRelatedWork W2082860237 @default.
- W1567376298 hasRelatedWork W2117258802 @default.
- W1567376298 hasRelatedWork W2130076355 @default.
- W1567376298 hasRelatedWork W2151865869 @default.
- W1567376298 hasRelatedWork W4234157524 @default.
- W1567376298 hasVolume "14" @default.
- W1567376298 isParatext "false" @default.
- W1567376298 isRetracted "false" @default.
- W1567376298 magId "1567376298" @default.
- W1567376298 workType "article" @default.