Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567381681> ?p ?o ?g. }
- W1567381681 abstract "In this thesis, several studies are described that elaborate on the biological properties of immunoglobulin free light chains (Ig-fLC) related to the activation of mast cells and effects on other cells. Mast cell degranulation through Ig-fLC requires two events. At first, mast cell-bound Ig-fLCs should be able to recognize and bind antigen to facilitate crosslinking. Subsequently, receptor crosslinking must be translated into an intracellular signal that initiates a downstream signalling pathway eventually leading to mast cell activation. The second chapter describes the identification of the key intracellular signal transducing element responsible for transmitting the activating signal inside mast cells after Ig-fLC binding and crosslinking. In chapter three, we provide further insight in the binding of antigen by Ig-fLC in vitro through various techniques. We also show that crosslinking is crucial to initiate an Ig-fLC-mediated hypersensitivity response in vivo. Ig-fLC may also exert biological effects via other cells than mast cells. We show that Ig-fLC can activate neutrophils to release CXCL8. In the last part of this thesis, research is expanded towards other myeloid cells and provides new insights into the capability of Ig-fLC to induce immunological effects. In conclusion, studies in this thesis further delineate the mast cell-activating potential of IgLCs and expands our current knowledge about their role in immunology." @default.
- W1567381681 created "2016-06-24" @default.
- W1567381681 creator A5063649653 @default.
- W1567381681 date "2007-01-01" @default.
- W1567381681 modified "2023-09-26" @default.
- W1567381681 title "Immunoglobulin free light chains: new insights in mast cell activation and immunology" @default.
- W1567381681 cites W11286555 @default.
- W1567381681 cites W1481474581 @default.
- W1567381681 cites W1488366875 @default.
- W1567381681 cites W1492931340 @default.
- W1567381681 cites W1501676434 @default.
- W1567381681 cites W1509664796 @default.
- W1567381681 cites W1525588573 @default.
- W1567381681 cites W1540791408 @default.
- W1567381681 cites W1541594543 @default.
- W1567381681 cites W1547231479 @default.
- W1567381681 cites W1557825564 @default.
- W1567381681 cites W1561484173 @default.
- W1567381681 cites W1571009899 @default.
- W1567381681 cites W1577692544 @default.
- W1567381681 cites W1580898910 @default.
- W1567381681 cites W1605522372 @default.
- W1567381681 cites W1663041213 @default.
- W1567381681 cites W1865263763 @default.
- W1567381681 cites W1869403232 @default.
- W1567381681 cites W1897083767 @default.
- W1567381681 cites W1955032214 @default.
- W1567381681 cites W1955975006 @default.
- W1567381681 cites W1960538598 @default.
- W1567381681 cites W1963832744 @default.
- W1567381681 cites W1969299127 @default.
- W1567381681 cites W1972447401 @default.
- W1567381681 cites W1974612463 @default.
- W1567381681 cites W1975468167 @default.
- W1567381681 cites W1978078815 @default.
- W1567381681 cites W1979028882 @default.
- W1567381681 cites W1982168426 @default.
- W1567381681 cites W1982709334 @default.
- W1567381681 cites W1984050845 @default.
- W1567381681 cites W1989731057 @default.
- W1567381681 cites W1990367169 @default.
- W1567381681 cites W1992363777 @default.
- W1567381681 cites W1994553156 @default.
- W1567381681 cites W1994682897 @default.
- W1567381681 cites W1995225848 @default.
- W1567381681 cites W1995457719 @default.
- W1567381681 cites W1995827138 @default.
- W1567381681 cites W1996445917 @default.
- W1567381681 cites W1997632949 @default.
- W1567381681 cites W1999140904 @default.
- W1567381681 cites W2001140826 @default.
- W1567381681 cites W2002658669 @default.
- W1567381681 cites W2003414137 @default.
- W1567381681 cites W2005372778 @default.
- W1567381681 cites W2006579465 @default.
- W1567381681 cites W2008182609 @default.
- W1567381681 cites W2008568865 @default.
- W1567381681 cites W2009443641 @default.
- W1567381681 cites W2009979848 @default.
- W1567381681 cites W2012143505 @default.
- W1567381681 cites W2013249891 @default.
- W1567381681 cites W2013635745 @default.
- W1567381681 cites W2018593820 @default.
- W1567381681 cites W2020448898 @default.
- W1567381681 cites W2022733921 @default.
- W1567381681 cites W2025339753 @default.
- W1567381681 cites W2030116885 @default.
- W1567381681 cites W2030479446 @default.
- W1567381681 cites W2032247891 @default.
- W1567381681 cites W2032477655 @default.
- W1567381681 cites W2036098682 @default.
- W1567381681 cites W2037182203 @default.
- W1567381681 cites W2039187377 @default.
- W1567381681 cites W2039252747 @default.
- W1567381681 cites W2039962221 @default.
- W1567381681 cites W2040337023 @default.
- W1567381681 cites W2041251823 @default.
- W1567381681 cites W2041406972 @default.
- W1567381681 cites W2043546340 @default.
- W1567381681 cites W2043796257 @default.
- W1567381681 cites W2044269184 @default.
- W1567381681 cites W2046130452 @default.
- W1567381681 cites W2047796994 @default.
- W1567381681 cites W2049374822 @default.
- W1567381681 cites W2050927750 @default.
- W1567381681 cites W2051559431 @default.
- W1567381681 cites W2055722861 @default.
- W1567381681 cites W2057260415 @default.
- W1567381681 cites W2061071534 @default.
- W1567381681 cites W2062453230 @default.
- W1567381681 cites W2063287346 @default.
- W1567381681 cites W2063800157 @default.
- W1567381681 cites W2065364569 @default.
- W1567381681 cites W2067620014 @default.
- W1567381681 cites W2069375519 @default.
- W1567381681 cites W2071957953 @default.
- W1567381681 cites W2075689961 @default.
- W1567381681 cites W2076096345 @default.
- W1567381681 cites W2088803695 @default.
- W1567381681 cites W2089327657 @default.