Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567386892> ?p ?o ?g. }
- W1567386892 abstract "Under pathological conditions such as tissue inflammation, ischemic stroke, traumatic brain injury, and epileptic seizure, accumulations of lactic acid due to enhanced anaerobic glucose metabolism and the release of proton from ATP hydrolysis result in significant reduction of tissue pH, a condition termed acidosis. Acidosis can activate a distinct family of ion channels: acid-sensing ion channels (ASICs) (Waldmann et al., 1997b), which are heavily expressed in the peripheral sensory and central neurons (Waldmann & Lazdunski, 1998; Krishtal, 2003; Wemmie et al., 2006; Lingueglia, 2007; Xiong et al., 2006, 2007, 2008; Sluka et al., 2009). ASICs belong to the amiloride-sensitive degenerin/epithelial Na+ channel (DEG/ENaC) superfamily (Kellenberger & Schild, 2002). Four genes (ACCN1 4) encoding at least six ASIC subunits have been cloned. Each subunit has two transmembrane domains with a large extracellular loop and short intracellular Nand C-termini (Waldmann et al., 1997b). Functional ASICs are trimeric complexes of these subunits (Jasti et al., 2007; Gonzales et al., 2009) and most of these subunits can form homomeric and/or heteromeric channels (Benson et al., 2002; Baron et al., 2002, 2008; Wemmie et al., 2002, 2003; Askwith et al., 2004; Chu et al., 2004, 2006; Xiong et al., 2004; Zha et al., 2006; Sherwood et al., 2011). ASICs are enriched in brain neurons (Alvarez de la Rosa et al., 2003; Wemmie et al., 2003; Xiong et al., 2004; Sherwood et al., 2011), where at least three (ASIC1a, ASIC2a and ASIC2b) of the seven subunits can be found. ASIC1a is the dominant subunit in brain and homomeric ASIC1a and heteromeric ASIC1a/2b channels are permeable to both Na+ and Ca2+ ions (Waldmann et al., 1997b; Yermolaieva et al., 2004; Zha et al., 2006; Sherwood et al., 2011). ASICs are inhibited by the diuretic amiloride, a non-specific ASIC blocker (Waldmann et al., 1997b). The tarantula toxin psalmotoxin 1 (PcTX1) blocks the homomeric ASIC1a (Escoubas et al., 2000) and heteromeric ASIC1a/2b (Sherwood et al., 2011) channels. The roles of ASICs in a variety of neurologic conditions are still under active investigation. ASIC1a channels localize at synapse and contribute to synaptic plasticity, learning/memory, and fear conditioning (Wemmie et al., 2002, 2003, 2004). Activation of Ca2+-permeable homomeric ASIC1a and heteromeric ASIC1a/2b channels is involved in acidosis-mediated ischemic" @default.
- W1567386892 created "2016-06-24" @default.
- W1567386892 creator A5015897926 @default.
- W1567386892 creator A5040922635 @default.
- W1567386892 creator A5067769516 @default.
- W1567386892 date "2011-12-09" @default.
- W1567386892 modified "2023-10-16" @default.
- W1567386892 title "Acid-Sensing Ion Channels in Neurodegenerative Diseases: Potential Therapeutic Target" @default.
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