Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567401877> ?p ?o ?g. }
- W1567401877 endingPage "231" @default.
- W1567401877 startingPage "209" @default.
- W1567401877 abstract "Three of the respiratory chain complexes contain essential iron-sulfur (Fe/S) cluster prosthetic groups. Besides respiration, these ancient inorganic cofactors are also necessary for numerous other fundamental biochemical processes in virtually every known organism. Both the synthesis of Fe/S clusters and their delivery to apoproteins depend on the concerted function of specialized, often dedicated, proteins located in the mitochondria and cytosol of eukaryotes. Impaired function of the mitochondria-located Fe/S cluster (ISC) assembly machinery affects all cellular Fe/S proteins, including enzymes of the respiratory chain, NADH: ubiquinone oxidoreductase (complex I; eight Fe/S clusters), succinate: ubiquinone oxidoreductase (complex II; three Fe/S clusters), and cytochrome bc(1) complex (complex III; one Fe/S cluster). Here, we describe strategies and techniques both to deprive respiratory chain proteins of their Fe/S cofactors and to study changes in activity and composition of these proteins. As examples, we present the results of the depletion of two types of Fe/S biogenesis proteins, huNfs1 and huInd1, in a human tissue culture model. The ISC assembly component huNfs1 is required for biogenesis of all cellular Fe/S proteins, its loss exerting pleiotropic effects, whereas huInd1 is specific for Fe/S cluster maturation of complex I. Disorders in Fe/S cluster assembly are candidate causes for defects in respiratory complex assembly of unknown etiology." @default.
- W1567401877 created "2016-06-24" @default.
- W1567401877 creator A5046475529 @default.
- W1567401877 creator A5058245619 @default.
- W1567401877 creator A5072379388 @default.
- W1567401877 date "2009-01-01" @default.
- W1567401877 modified "2023-09-23" @default.
- W1567401877 title "Chapter 12 twelve Controlled Expression of Iron‐Sulfur Cluster Assembly Components for Respiratory Chain Complexes in Mammalian Cells" @default.
- W1567401877 cites W1431301684 @default.
- W1567401877 cites W1484379620 @default.
- W1567401877 cites W1541799695 @default.
- W1567401877 cites W1569716332 @default.
- W1567401877 cites W1600996828 @default.
- W1567401877 cites W1806470722 @default.
- W1567401877 cites W1975390562 @default.
- W1567401877 cites W1975610860 @default.
- W1567401877 cites W1977203945 @default.
- W1567401877 cites W1985844569 @default.
- W1567401877 cites W1986251916 @default.
- W1567401877 cites W1996330065 @default.
- W1567401877 cites W2001801014 @default.
- W1567401877 cites W2006358233 @default.
- W1567401877 cites W2008564265 @default.
- W1567401877 cites W2018506581 @default.
- W1567401877 cites W2025348458 @default.
- W1567401877 cites W2031212222 @default.
- W1567401877 cites W2034102741 @default.
- W1567401877 cites W2036794960 @default.
- W1567401877 cites W2037074028 @default.
- W1567401877 cites W2038783205 @default.
- W1567401877 cites W2041398967 @default.
- W1567401877 cites W2043828851 @default.
- W1567401877 cites W2048871728 @default.
- W1567401877 cites W2049043816 @default.
- W1567401877 cites W2053799680 @default.
- W1567401877 cites W2056799965 @default.
- W1567401877 cites W2057404038 @default.
- W1567401877 cites W2064063908 @default.
- W1567401877 cites W2070121678 @default.
- W1567401877 cites W2078187809 @default.
- W1567401877 cites W2080261054 @default.
- W1567401877 cites W2082467606 @default.
- W1567401877 cites W2082520757 @default.
- W1567401877 cites W2087921651 @default.
- W1567401877 cites W2101901686 @default.
- W1567401877 cites W2103392842 @default.
- W1567401877 cites W2109398579 @default.
- W1567401877 cites W2112438801 @default.
- W1567401877 cites W2114438238 @default.
- W1567401877 cites W2114484640 @default.
- W1567401877 cites W2116899346 @default.
- W1567401877 cites W2130210612 @default.
- W1567401877 cites W2133155560 @default.
- W1567401877 cites W2139871850 @default.
- W1567401877 cites W2143313350 @default.
- W1567401877 cites W2143602831 @default.
- W1567401877 cites W2144175569 @default.
- W1567401877 cites W2149485430 @default.
- W1567401877 cites W2152896217 @default.
- W1567401877 cites W2165586566 @default.
- W1567401877 cites W2166595673 @default.
- W1567401877 cites W2170781554 @default.
- W1567401877 cites W2171717651 @default.
- W1567401877 cites W2216844357 @default.
- W1567401877 cites W2333258262 @default.
- W1567401877 cites W2419363754 @default.
- W1567401877 doi "https://doi.org/10.1016/s0076-6879(08)04412-1" @default.
- W1567401877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19348891" @default.
- W1567401877 hasPublicationYear "2009" @default.
- W1567401877 type Work @default.
- W1567401877 sameAs 1567401877 @default.
- W1567401877 citedByCount "22" @default.
- W1567401877 countsByYear W15674018772012 @default.
- W1567401877 countsByYear W15674018772013 @default.
- W1567401877 countsByYear W15674018772014 @default.
- W1567401877 countsByYear W15674018772018 @default.
- W1567401877 countsByYear W15674018772019 @default.
- W1567401877 countsByYear W15674018772021 @default.
- W1567401877 countsByYear W15674018772022 @default.
- W1567401877 countsByYear W15674018772023 @default.
- W1567401877 crossrefType "book-chapter" @default.
- W1567401877 hasAuthorship W1567401877A5046475529 @default.
- W1567401877 hasAuthorship W1567401877A5058245619 @default.
- W1567401877 hasAuthorship W1567401877A5072379388 @default.
- W1567401877 hasConcept C104317684 @default.
- W1567401877 hasConcept C131934819 @default.
- W1567401877 hasConcept C181199279 @default.
- W1567401877 hasConcept C185592680 @default.
- W1567401877 hasConcept C197957613 @default.
- W1567401877 hasConcept C2777852564 @default.
- W1567401877 hasConcept C2779268744 @default.
- W1567401877 hasConcept C28859421 @default.
- W1567401877 hasConcept C3020377403 @default.
- W1567401877 hasConcept C3020761558 @default.
- W1567401877 hasConcept C55493867 @default.
- W1567401877 hasConcept C66517615 @default.
- W1567401877 hasConcept C86803240 @default.
- W1567401877 hasConcept C95444343 @default.