Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567403376> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1567403376 endingPage "1528" @default.
- W1567403376 startingPage "1523" @default.
- W1567403376 abstract "OBJECTIVES To assess, in vitro, the effect of Amifostine (AMF, WR-2721) on angiogenesis and levels of vascular endothelial growth factor (VEGF) secreted from hemopoietic stem/progenitor cell populations. METHODS We conducted the study in the research laboratories of the Hashemite University, Jordan between September 2003 and January 2005 where we took samples were from Myelodysplastic syndrome (MDS) patients and healthy donors attending Al-Hussein Cancer Center and We determined the proliferation of human umbilical vein endothelial cells (HUVECs) in cultures supplemented with media conditioned with AMF-treated and AMF-untreated pure hemopoietic cells [CD34+ cells, and erythroid, myeloid and megakaryocytic progenitors]. Furthermore, in the same conditioned media, we evaluated levels of elaborated VEGF by a sensitive enzyme linked immunosorbent assay. RESULTS Biologically, media conditioned with AMF-treated cells reduced proliferation of HUVECs compared to media conditioned with untreated control cells (p<0.05). In cultures of AMF-untreated cells, elaboration of VEGF was higher (p<0.05) in media conditioned with cells from MDS patients compared to healthy donors. A 30 minutes pre-exposure of cells to AMF (500 mM) suppressed levels of VEGF secreted within 24 hours in 63 of 89 evaluated cultures. The percentage of reduction of VEGF in AMF-sensitive cultures was comparable in cultures of MDS cells (18%, 2-37%; median, range) and normal cells (12%, 2-45%). CONCLUSIONS The results showed that AMF exerts an anti-angiogenic activity and suppresses the secretion of VEGF in hemopoietic stem/progenitor cells obtained from both healthy individuals and patients with MDS." @default.
- W1567403376 created "2016-06-24" @default.
- W1567403376 creator A5022927246 @default.
- W1567403376 creator A5041005435 @default.
- W1567403376 creator A5065051913 @default.
- W1567403376 creator A5090785554 @default.
- W1567403376 date "2005-06-13" @default.
- W1567403376 modified "2023-09-23" @default.
- W1567403376 title "Amifostine exerts anti-angiogenic activity and suppresses vascular endothelial growth factor secreted by hemopoietic stem/progenitor cells." @default.
- W1567403376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16228049" @default.
- W1567403376 hasPublicationYear "2005" @default.
- W1567403376 type Work @default.
- W1567403376 sameAs 1567403376 @default.
- W1567403376 citedByCount "2" @default.
- W1567403376 crossrefType "journal-article" @default.
- W1567403376 hasAuthorship W1567403376A5022927246 @default.
- W1567403376 hasAuthorship W1567403376A5041005435 @default.
- W1567403376 hasAuthorship W1567403376A5065051913 @default.
- W1567403376 hasAuthorship W1567403376A5090785554 @default.
- W1567403376 hasConcept C10205521 @default.
- W1567403376 hasConcept C109159458 @default.
- W1567403376 hasConcept C123012128 @default.
- W1567403376 hasConcept C126322002 @default.
- W1567403376 hasConcept C134018914 @default.
- W1567403376 hasConcept C16685009 @default.
- W1567403376 hasConcept C167734588 @default.
- W1567403376 hasConcept C201750760 @default.
- W1567403376 hasConcept C202751555 @default.
- W1567403376 hasConcept C203014093 @default.
- W1567403376 hasConcept C2776694085 @default.
- W1567403376 hasConcept C2777025900 @default.
- W1567403376 hasConcept C2777411675 @default.
- W1567403376 hasConcept C2778271429 @default.
- W1567403376 hasConcept C2779387952 @default.
- W1567403376 hasConcept C2780394083 @default.
- W1567403376 hasConcept C28328180 @default.
- W1567403376 hasConcept C502942594 @default.
- W1567403376 hasConcept C55493867 @default.
- W1567403376 hasConcept C71924100 @default.
- W1567403376 hasConcept C86803240 @default.
- W1567403376 hasConcept C95444343 @default.
- W1567403376 hasConceptScore W1567403376C10205521 @default.
- W1567403376 hasConceptScore W1567403376C109159458 @default.
- W1567403376 hasConceptScore W1567403376C123012128 @default.
- W1567403376 hasConceptScore W1567403376C126322002 @default.
- W1567403376 hasConceptScore W1567403376C134018914 @default.
- W1567403376 hasConceptScore W1567403376C16685009 @default.
- W1567403376 hasConceptScore W1567403376C167734588 @default.
- W1567403376 hasConceptScore W1567403376C201750760 @default.
- W1567403376 hasConceptScore W1567403376C202751555 @default.
- W1567403376 hasConceptScore W1567403376C203014093 @default.
- W1567403376 hasConceptScore W1567403376C2776694085 @default.
- W1567403376 hasConceptScore W1567403376C2777025900 @default.
- W1567403376 hasConceptScore W1567403376C2777411675 @default.
- W1567403376 hasConceptScore W1567403376C2778271429 @default.
- W1567403376 hasConceptScore W1567403376C2779387952 @default.
- W1567403376 hasConceptScore W1567403376C2780394083 @default.
- W1567403376 hasConceptScore W1567403376C28328180 @default.
- W1567403376 hasConceptScore W1567403376C502942594 @default.
- W1567403376 hasConceptScore W1567403376C55493867 @default.
- W1567403376 hasConceptScore W1567403376C71924100 @default.
- W1567403376 hasConceptScore W1567403376C86803240 @default.
- W1567403376 hasConceptScore W1567403376C95444343 @default.
- W1567403376 hasIssue "10" @default.
- W1567403376 hasLocation W15674033761 @default.
- W1567403376 hasLocation W15674033762 @default.
- W1567403376 hasOpenAccess W1567403376 @default.
- W1567403376 hasPrimaryLocation W15674033761 @default.
- W1567403376 hasRelatedWork W16503128 @default.
- W1567403376 hasRelatedWork W1973364893 @default.
- W1567403376 hasRelatedWork W2015963921 @default.
- W1567403376 hasRelatedWork W2051009364 @default.
- W1567403376 hasRelatedWork W2056972582 @default.
- W1567403376 hasRelatedWork W2063228842 @default.
- W1567403376 hasRelatedWork W2075754372 @default.
- W1567403376 hasRelatedWork W2086065240 @default.
- W1567403376 hasRelatedWork W2149295197 @default.
- W1567403376 hasRelatedWork W2322070115 @default.
- W1567403376 hasRelatedWork W2323911397 @default.
- W1567403376 hasRelatedWork W2398653725 @default.
- W1567403376 hasRelatedWork W2409547420 @default.
- W1567403376 hasRelatedWork W2412455219 @default.
- W1567403376 hasRelatedWork W2418048479 @default.
- W1567403376 hasRelatedWork W2435867567 @default.
- W1567403376 hasRelatedWork W2444519531 @default.
- W1567403376 hasRelatedWork W2584325162 @default.
- W1567403376 hasRelatedWork W3030874685 @default.
- W1567403376 hasRelatedWork W2416106152 @default.
- W1567403376 hasVolume "26" @default.
- W1567403376 isParatext "false" @default.
- W1567403376 isRetracted "false" @default.
- W1567403376 magId "1567403376" @default.
- W1567403376 workType "article" @default.